Klinefelter's Syndrome Accompanied by Mixed Connective Tissue Disease and Diabetes Mellitus.

Takeuchi, Yutaka; Murata, Yasutaka; Sintani, J; Masukawa, Hiroshi; Nakamura, Ryô; Oi, Keiko; Kato, Yumiko; Niinomi, Mitsuro

doi:10.2169/internalmedicine.38.875

Cited by 21 publications

(17 citation statements)

References 16 publications

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“…Tada and Hayashi also reported an involvement of glucose-6-phosphate dehydrogenase whose gene was in the chromosome, in the glucose metabolic dysfunction (8). Some Klinefelter's syndrome patients with diabetes revealed positive islet cell surface antibody and a clinical course of SPIDDM(9), and autoimmune diseases such as systemic lupus erythematodes were reported to frequently accompany Klinefelter's syndrome (5,10,37). Therefore, an autoimmunemechanism may be involved in the development of diabetes in the syndrome.…”

Section: Case Reportmentioning

confidence: 99%

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Diabetes Mellitus Associated with Klinefelter's Syndrome: A Case Report and Review in Japan.

et al. 2002

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Wereport a case of Klinefelter's syndrome in a 48-yearold man who had diabetes mellitus associated with severe insulin resistance. Wediagnosed him with Klinefelter's syndrome from his atrophic testicles, primary hypogonadism in hormonal examination, and a chromosomalaberration of 47,XXY. He showed severe decreased insulin sensitivity in a hyper-insulinemic euglycemic clamp test. He had injected over 100 units of insulin per day, however, testosterone replacement and administration of pioglitazone improved his glycemic control, which resulted in a decrease of insulin dose to less than 50 units per day. Here, we discuss the characteristics of diabetes mellitus associated with Klinefelter's syndrome in Japanese patients including this case. (Internal Medicine 41: 842-847, 2002)

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Section: Case Reportmentioning

confidence: 99%

“…It was reported that patients with Klinefelter's syndrome tended to have diabetes mellitus or autoimmune diseases (3)(4)(5). It has not been clarified why diabetes mellitus develops in patients with Klinefelter's syndrome, and what the characteristics of diabetes in the syndrome are.…”

Section: Introductionmentioning

confidence: 99%

Diabetes Mellitus Associated with Klinefelter's Syndrome: A Case Report and Review in Japan.

et al. 2002

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“…Another characteristic of KSis the concomitant occurrence of various autoimmunediseases such as rheumatoid arthritis, systemic lupus erythematosus (SLE), and thyroid autoimmune diseases. In this journal, Takeuchi et al (2) reported mixed connective tissue disease (MCTD), another associated autoimmunedisease, in a case of KS.…”

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confidence: 99%

Klinefelter''s Syndrome, Autoimmunity, and Associated Endocrinopathies

Aoki

1999

Intern. Med.

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“…[12,13] Men with KS are also at risk for autoimmune diseases, such as systemic lupus erythematosus. [14,15] One of the components of KS, hypogonadism, can lead to development of abdominal obesity, which may then have well-known consequences of development of metabolic syndrome and insulin resistance. Abdominal obesity may also lead to lower testosterone levels.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Androgen Replacement Therapy on Glycemic Control in a Case with Klinefelter Syndrome and Poorly Controlled Diabetes

Özderya¹

2017

South Clin Ist Euras

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Klinefelter syndrome (KS) is the most common sex chromosome anomaly among men. It is usually characterized by hypergonadotropic hypogonadism, eunuchoid body structure, and most often, 47,XXY karyotype. Studies have shown that KS patients have high risk of developing autoimmune diseases and diabetes, and the hypogonadism that accompanies the syndrome makes regulation of diabetes more difficult. A 39-year-old man with KS was admitted to Endocrinology and Metabolic Diseases Polyclinic because of increased blood glucose level: His glycated hemoglobin (HbA1c) value was 14.9%. He had diabetes for approximately 5 years and was using 80 IU insulin daily at time of admission, but after testosterone replacement therapy, his insulin requirement decreased to 60 units. Follow-up HbA1c was 7.7% after 2 months of androgen replacement therapy. Hypoandrogenemia may contribute to development of newly diagnosed diabetes or deterioration of pre-existing diabetes. Testosterone replacement therapy can improve glycemic control in these patients.

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Klinefelter's Syndrome Accompanied by Mixed Connective Tissue Disease and Diabetes Mellitus.

Cited by 21 publications

References 16 publications

Diabetes Mellitus Associated with Klinefelter's Syndrome: A Case Report and Review in Japan.

Diabetes Mellitus Associated with Klinefelter's Syndrome: A Case Report and Review in Japan.

Klinefelter''s Syndrome, Autoimmunity, and Associated Endocrinopathies

The Effects of Androgen Replacement Therapy on Glycemic Control in a Case with Klinefelter Syndrome and Poorly Controlled Diabetes

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