Klinische und elektrokardiographische Effekte von Gallopamil und Nifedipin unter ISDN-Basistherapie bei Patienten mit koronarer Herzkrankheit

Bachour, G

doi:10.1007/978-3-642-72414-5_17

Cited by 3 publications

(1 citation statement)

References 2 publications

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“…In any case, improvement in the sectors with the strongest functional impairment from rest to exercise, i.e., the frankest ischemia, is unequivocal. The addition of gallopamil with its partly different location of action, i. e. the muscle cells of the working heart muscle as well as the smooth muscle of the vessel wall [22], shows that anti-ischemic drug effects can be increased by a combination of different pharmacodynamic principles [34,35]. Drug levels increased only slightly from 2 h to 4 h after administration, so that further improvement at the 4 h exercise test must be ascribed to the addition of gallopamil.…”

Section: Discussionmentioning

confidence: 99%

Lack of tolerance after chronic administration of controlled-release isosorbide-5-mononitrate

Stauch

Großmann

Wanjura

et al. 1990

Eur J Clin Pharmacol

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The effect of a controlled-release formulation of isosorbide-5-mononitrate (IS-5-MN) was studied in patients with coronary heart disease (CHD), with the aim of comparing the acute effect with that after chronic administration on parameters of ischemia. To determine whether any tolerance developed, several aspects of ischemia were observed: ECG signs, clinical parameters, and left ventricular function. Fifteen patients with angiographically proven CHD were examined with 12-lead exercise ECG before, 2 h and 4 h after the first dose and after 10 days of therapy with 60 mg IS-5-MN (Coleb-Duriles) once daily. After 7 days, three radionuclide ventriculographies were performed: control, 2 h after nitrate and 2 h after 75 mg gallopamil. Plasma concentrations of IS-5-MN were measured before every exercise test. The results showed a reduction of total ST-segment depression from 0.59 mV to 0.29 mV after 2 h (NS) and 4 h (P less than 0.05) on the 1st day and from 0.48 mV to 0.32 mV (P less than 0.05) and 0.31 mV (NS) after 10 days. The severity of angina pectoris was diminished by about 50%. The effect on exercise duration and time to ST-segment depression by more than 0.1 mV remained unchanged after 10 days, whereas the effect on blood pressure, heart rate and time to onset of angina was attenuated. The mean decrease in ejection fraction (EF) from rest to exercise was reduced from--5.9% to -1.9% (P less than 0.05) after nitrate, while an increase of +1.4% was seen after gallopamil (P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 99%

Lack of tolerance after chronic administration of controlled-release isosorbide-5-mononitrate

Stauch

Großmann

Wanjura

et al. 1990

Eur J Clin Pharmacol

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Unerwünschte Wirkungen von Calciumantagonisten unter besonderer Berücksichtigung der Verträglichkeit von Gallopamil

Walter‐Sack¹

1996

Calciumantagonisten

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Fehlende Toleranz bei chronischer Anwendung von kontrolliert-freigesetztem Isosorbid-5-Mononitrat

Stauch

1991

Eur J Clin Pharmacol

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The antidepressant efficacy and adverse-effects of rolipram (a dialkoxyphenyl-2-pyrrolidone) were compared to those of amitriptyline in the treatment of depressive illness requiring hospital admission in a double-blind study. Fifty patients meeting DSM-III criteria for Major Depression whose scores on the Hamilton Rating Scale for Depression (HRSD) remained above 17 after 5 to 7 days on placebo were randomly allocated to either treatment. The rate of recovery in those patients treated by amitriptyline was substantially greater than in those patients treated by rolipram. Twice as many patients dropped out of treatment by rolipram because of lack of efficacy or adverse-effects compared with patients treated by amitriptyline. Rolipram produced fewer adverse-effects attributable to cholinergic blockade, but more nausea. We conclude that amitriptyline is more effective than rolipram in the treatment of depressed hospital in-patients.

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Klinische und elektrokardiographische Effekte von Gallopamil und Nifedipin unter ISDN-Basistherapie bei Patienten mit koronarer Herzkrankheit

Cited by 3 publications

References 2 publications

Lack of tolerance after chronic administration of controlled-release isosorbide-5-mononitrate

Lack of tolerance after chronic administration of controlled-release isosorbide-5-mononitrate

Unerwünschte Wirkungen von Calciumantagonisten unter besonderer Berücksichtigung der Verträglichkeit von Gallopamil

Fehlende Toleranz bei chronischer Anwendung von kontrolliert-freigesetztem Isosorbid-5-Mononitrat

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