Klinische und histopathologische Charakteristika des initialen Leser-Trélat-Syndroms

Barth, G; Basten, O.; Rüschoff, Josef; Rompel, Rainer

doi:10.1007/s001050170108

Cited by 7 publications

(3 citation statements)

References 15 publications

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“…Cases of breast cancer, lung cancer, lymphoproliferative disorders and melanoma have also been described [. While the exact pathogenesis of LTS remains unclear, increased production of growth factors (epidermal and transforming growth factor alpha) are thought to play a role [.…”

Section: Skin Diseases Along the Skin Tension Linesmentioning

confidence: 99%

Linear patterns of the skin and their dermatoses

Senner

Eicher

Nasifoglu

et al. 2020

J Deutsche Derma Gesell

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Knowledge about the linear patterns of the skin is a key competence of dermatologists. Four major groups of linear patterns can be distinguished: Langer lines, dermatomes, Blaschko lines and exogenous patterns. Langer lines run in the direction of the underlying collagen fibers (least skin tension) and play an important diagnostic role for some exanthematous skin diseases. In the thoracodorsal region, the distribution of the Langer lines gives rise to what is referred to as a 'Christmas tree pattern'. A dermatome is an area of skin that is supplied by a single spinal nerve. Disorders with a neuronal origin follow this pattern of distribution. The lines of Blaschko delineate the lines of migration of epidermal cells during embryogenesis. Exogenous linear patterns are caused by external factors.The present CME article will highlight important skin disorders that primarily present in the form of one of the aforementioned patterns. In addition, we will also address skin conditions that may secondarily follow with these patterns (or distinctly not do so) as the result of various mechanisms such as the Koebner phenomenon, reverse Koebner phenomenon, and Wolf's isotopic response.

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Section: Skin Diseases Along the Skin Tension Linesmentioning

confidence: 99%

Linear patterns of the skin and their dermatoses

Senner

Eicher

Nasifoglu

et al. 2020

J Deutsche Derma Gesell

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“…Außerdem wurden Fälle von Brust‐, Lungenkarzinomen und lymphoproliferativen Erkrankungen, aber auch malignen Melanomen nach LTS beschrieben . Wenngleich die Pathogenese des LTS bislang unklar ist, spielen vermutlich die im Rahmen der Neoplasie vermehrt produzierten Wachstumsfaktoren (epidermal und transforming growth factor alpha) eine Rolle .…”

Section: Eruptive Seborrhoische Keratosen Und Leser‐trélat‐syndromunclassified

Die Linienmuster der Haut und ihre Dermatosen

Senner

Eicher

Nasifoglu

et al. 2020

J Deutsche Derma Gesell

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Zusammenfassung Die Kenntnis der Linienmuster der Haut stellt eine Schlüsselkompetenz für jeden Dermatologen dar. Vier Hauptgruppen von Linienmustern sind relevant: Langer‐Linien, Dermatome, Blaschko‐Linien und exogene Muster. Die Langer‐Linien markieren die Richtung der geringsten Spannung der Haut und sind diagnostisch wichtig für einige exanthematische Hauterkrankungen. Die thorakodorsale Manifestation der Langer‐Linien wurde als christmas tree pattern herausgestellt. Dermatome sind Hautfelder, die von den sensiblen Spinalnerven innerviert werden. Hauterkrankungen mit neuronaler Pathogenese folgen diesem Muster. Blaschko‐Linien sind kutane Manifestationen genetischer Mosaike, die während der Embryogenese entstehen. Exogene lineare Muster werden durch äußere Faktoren verursacht. Im Folgenden werden einerseits primär in diesen Mustern auftretende Dermatosen besprochen und andererseits Hauterkrankungen aufgezeigt, die sekundär durch Mechanismen der Anbindung (wie Köbner‐Phänomen, Renbök‐Phänomen oder isotope Reaktion) diesen Mustern folgen oder diese aussparen.

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“…The sign of Leser-Trelat (SLT) is the sudden eruption of multiple seborrheic keratoses on skin of trunk and extremities. The association of this syndrome with internal malignity has been described (1)(2)(3)(4)(5). It is considered a paraneoplastic dermatosis (1).…”

Section: Introductionmentioning

confidence: 99%

Acanthosis nigricans and the sign of leser-trelat associated with primary brain tumor: Case report

2008

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The authors present a case of a female patient a 26-year old pensioner from Zmajevo, who developed skin changes in the neck region, armpits and groins, as well as in submammal folds during the 10 years period. The changes include dark-brown hyperpigmentation associated with sudden eruption of a large number of benign skin tumors and dark-brown seborrheic keratosis on trunk and extremities. In 1998, after magnetic resonance imaging, primary brain tumor of astrocytoma type with low grade of malignity was discovered in thalamus region. The patient developed the above-mentioned skin changes since then. According to neurosurgical findings, the brain tumor is inoperable, so skin changes are persistent and stationary. Clinical changes correspond to paraneoplastic form of acanthosis nigricans. Numerous skin tumors histopathologically match seborrheic keratosis and reveal the clinical features of the sign of Leser-Trelat. It is interesting that in the same patient there are both, obligatory and optional, paraneoplastic dermatoses associated with malignant brain tumor

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Klinische und histopathologische Charakteristika des initialen Leser-Trélat-Syndroms

Cited by 7 publications

References 15 publications

Linear patterns of the skin and their dermatoses

Linear patterns of the skin and their dermatoses

Die Linienmuster der Haut und ihre Dermatosen

Acanthosis nigricans and the sign of leser-trelat associated with primary brain tumor: Case report

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