KMnO4/HOAc system promoted one-pot synthesis of benzoxazoles from o-aminophenols or oxidative cyclization of o-hydroxyarylidene anilines at room temperature

Mirjalili, Bi Bi Fatemeh; Bamoniri, Abdolhamid; Bagheri, E.

doi:10.1007/s13738-015-0795-5

Cited by 3 publications

(1 citation statement)

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“…The inhibitory activity of these compounds had stronger anti‐AChE activity compared to the reference donepezil. By condensing o‐phenylenediamine, 2aminophenol, 2‐aminothiophenol with pyridine‐4‐ carbalehyde under various conditions, benzimidazole, benzoxazole [77] and benzothiazole rings were synthesized. Target products were obtained from the reaction of these synthesized rings with benzyl halides in dry acetonitrile.…”

Section: Benzimidazoles and Benzoxazoles In Alzheimer's Disease Treat...mentioning

confidence: 99%

Benzimidazole and Benzoxazole Derivatives Against Alzheimer's Disease

Faydalı,

Arpacı

2024

Chemistry & Biodiversity

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Benzimidazole and benzoxazole derivatives are included in the category of medical drugs in a wide range of areas such as anticancer, anticoagulant, antihypertensive, anti‐inflammatory, antimicrobial, antiparasitic, antiviral, antioxidant, immunomodulators, proton pump inhibitors, hormone modulators, etc. Many researchers have focused on synthesizing more effective benzimidazole and benzoxazole derivatives for screening various biological activities. In addition, there are benzimidazole and benzoxazole rings as bioisosteres of aromatic rings found in drugs used in the treatment of Alzheimer's disease. Because of the diverse activity of the benzimidazole and benzoxazole rings and bioisosteres marketed as drugs for Alzheimer Diseases, designed compounds containing these rings are likely to be effective against Alzheimer's disease. In this study, the effectiveness of compounds containing benzimidazole and benzoxazole rings against Alzheimer's disease will be examined.

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Section: Benzimidazoles and Benzoxazoles In Alzheimer's Disease Treat...mentioning

confidence: 99%