Knee Osteochondral Autologous Transplantation: Long-term MR findings and clinical correlations

Tetta, Cecilia; Busacca, Maurizio; Moio, Antonio; Rinaldi, Raffaella; Delcogliano, Marco; Kon, Elizaveta; Filardo, Giuseppe; Marcacci, Maurilio; Albisinni, Ugo

doi:10.1016/j.ejrad.2009.05.011

Cited by 52 publications

(34 citation statements)

References 27 publications

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“…38 Indeed, it is not surprising that the weighting of the parameters of the MOCART has been altered by 2 of the included studies to improve its prognostic value. 10,57 As MRI has drawbacks in terms of predictive value, second-look arthroscopy is still considered an important outcome measure. However, second-look arthroscopy may even have greater drawbacks, as it is invasive, does not allow for assessment of deeper structures (eg, the subchondral bone, ''deep'' osteophytes, and cysts), and shows limited correlation with clinical outcome.…”

Section: Discussionmentioning

confidence: 99%

Is Magnetic Resonance Imaging Reliable in Predicting Clinical Outcome After Articular Cartilage Repair of the Knee?

et al. 2013

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Section: Discussionmentioning

confidence: 99%

Is Magnetic Resonance Imaging Reliable in Predicting Clinical Outcome After Articular Cartilage Repair of the Knee?

et al. 2013

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“…The procedure may be carried out open or arthroscopically and is not recommended in (17). Good to excellent results have been reported in 85-95% of treated defects of the femoral condyles, tibial surfaces and patellar ⁄ trochlear lesions (38)(39)(40)(41)(42)(43).…”

Section: Autologous Osteochondral Grafting ⁄ Mosaicplastymentioning

confidence: 99%

Current strategies for knee cartilage repair

Kalson¹,

Gikas²,

Briggs³

2010

International Journal of Clinical Practice

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Summary Defects in knee articular cartilage (AC) can cause pain and disability and present the clinician with an extremely challenging clinical situation. This article describes the most up‐to‐date surgical techniques that aim to repair and/or regenerate symptomatic focal defects in AC, which include arthroscopic debridement, microfracture bone marrow stimulation and autologous osteochondral allografting, with an emphasis on autologous chondrocyte implantation. In the future, refinement of tissue‐engineering approaches promises to further improve outcome for these patients.

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“…With over 60% of all patient knee arthroscopies revealing hyaline cartilage lesions [1, 2], the high incidence of cartilage injuries presents significant economic burden on society [3]. Over the years, reparative clinical procedures that have been developed to address this problem include microfracturing [4], osteochondral autograft transfer, and mosaicplasty [5, 6] among others. Despite some positive mid- to long-term results, issues involving the formation of fibrous tissue, high patient morbidity, and poor graft preservation complicate clinical outcomes and render results unpredictable [7].…”

Section: Introductionmentioning

confidence: 99%

Generation of osteochondral tissue constructs with chondrogenically and osteogenically predifferentiated mesenchymal stem cells encapsulated in bilayered hydrogels

Lam

Meretoja

et al. 2014

Acta Biomaterialia

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This study investigated the capacity of chondrogenic and osteogenic pre-differentiation of mesenchymal stem cells (MSCs) for the development of osteochondral tissue constructs using injectable bilayered oligo(poly(ethylene glycol) fumarate) (OPF) hydrogel composites. We hypothesized that the combinatorial approach of encapsulating cell populations of both chondrogenic and osteogenic lineages in a spatially controlled manner within bilayered constructs would enable these cells to maintain their respective phenotypes via the exchange of biochemical factors even without the influence of external growth factors. During monolayer expansion prior to hydrogel encapsulation, it was found that 7 (CG7) and 14 (CG14) days of MSC exposure to TGF-β3 allowed for the generation of distinct cell populations with corresponding chondrogenic maturities as indicated by increasing aggrecan and type II collagen/type I collagen expression. Chondrogenic and osteogenic cells were then encapsulated within their respective (chondral/subchondral) layers in bilayered hydrogel composites to include four experimental groups. Encapsulated CG7 cells within the chondral layer exhibited enhanced chondrogenic phenotype when compared to other cell populations based on stronger type II collagen and aggrecan gene expression and higher glycosaminoglycans-to-hydroxyproline ratios. Osteogenic cells that were co-cultured with chondrogenic cells (in the chondral layer) showed higher cellularity over time, suggesting that chondrogenic cells stimulated the proliferation of osteogenic cells. Groups with osteogenic cells displayed mineralization in the subchondral layer, confirming the effect of osteogenic pre-differentiation. In summary, it was found that MSCs that underwent 7 days, but not 14 days, of chondrogenic pre-differentiation most closely resembled the phenotype of native hyaline cartilage when combined with osteogenic cells in a bilayered OPF hydrogel composite, indicating that the duration of chondrogenic preconditioning is an important factor to control. Furthermore, the respective chondrogenic and osteogenic phenotypes were maintained for 28 days in vitro without the need for external growth factors, demonstrating the exciting potential of this novel strategy for the generation of osteochondral tissue constructs for cartilage engineering applications.

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Knee Osteochondral Autologous Transplantation: Long-term MR findings and clinical correlations

Cited by 52 publications

References 27 publications

Is Magnetic Resonance Imaging Reliable in Predicting Clinical Outcome After Articular Cartilage Repair of the Knee?

Is Magnetic Resonance Imaging Reliable in Predicting Clinical Outcome After Articular Cartilage Repair of the Knee?

Current strategies for knee cartilage repair

Generation of osteochondral tissue constructs with chondrogenically and osteogenically predifferentiated mesenchymal stem cells encapsulated in bilayered hydrogels

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