Knee radiosynovectomy with 153Sm-hydroxyapatite compared to 90Y-hydroxyapatite: initial results of a prospective trial

Santos, Allan O.; Ricciardi, Janaina Bosso da Silva; Pagnano, Rodrigo Gonçalves; Pereira, Luis Fernando M; Sakuma, Emerson Taro Inoue; Matsuda, Margareth M.N.; Bernardes, Emerson Soares; Araújo, Elaine Bortoleti de; Brunetto, S. Q.; Takahashi, Maria Emília Seren; Brunetto, E.; Zulli, Roberto; Ozelo, Margareth C.; Etchebehere, Elba

doi:10.1007/s12149-020-01557-5

Cited by 3 publications

(3 citation statements)

References 26 publications

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“…Forty‐three studies had sample sizes > 20 knees 5–47 . Sixty‐eight studies were defined as small and were not discussed further.…”

Section: Resultsmentioning

confidence: 99%

Radiosynovectomy in haemophilic synovitis and arthropathy of the knee: A scoping review

Ray,

Rowbotham

2024

Haemophilia

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IntroductionRadiosynovectomy is an established treatment for chronic synovitis in patients with haemophilia. Although its role in rheumatological diseases has diminished, it remains an accepted therapy for haemophilic synovitis.AimThe aim of this scoping review was to map and summarise the evidence surrounding radiosynovectomy in haemophilic knees, identify gaps in the literature and inform future research.ResultsForty‐three manuscripts and abstracts were identified for this review. Evidence was limited to observational studies and Yttrium‐90 was the most studied licensed radioisotope. Radiosynovectomy was associated with a reduction in bleeding frequency and pain, improvements in range of motion and a reduction in the use of factor replacement.ConclusionThe literature reviewed lacks studies of sufficient methodological quality to permit systematic review and meta‐analysis. Systematic review using risk of bias assessment for observational studies should be undertaken to better evaluate the efficacy and safety of radiosynovectomy. A causal relationship between RSV and key clinical outcomes remains undetermined.

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“…Forty‐three studies had sample sizes > 20 knees 5–47 . Sixty‐eight studies were defined as small and were not discussed further.…”

Section: Resultsmentioning

confidence: 99%

Radiosynovectomy in haemophilic synovitis and arthropathy of the knee: A scoping review

Ray,

Rowbotham

2024

Haemophilia

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“…Albeit nuclear medicine treatments have been mainly engaged in oncology, some benign conditions, including hyperthyroidism and osteoarthropathy, may benefit from radionuclide therapy [49,50]. Santos et al [19] reported less hemarthrosis episodes using [ 153 Sm]Sm-HyA compared to the more commonly employed [ 90 Y]Y-HyA, in haemophiliac patients. Liepe and Baehr [20] accounted the effectiveness of erbium-169-based-one of the most interesting beta-emitting isotopes [51]-radiosynovectomy in thumb basal joint arthritis.…”

Section: Discussionmentioning

confidence: 99%

“…Santos et al [19] prospectively assessed the efficacy and safety of knee radiosynovectomy with [ 153 Sm]Sm-Hydroxyapatite (HyA) in comparison to the more commonly used [ 90 Y]Y-HyA in haemophiliac patients to prevent secondary arthropathy. Knee radiosynovectomy with [ 153 Sm]Sm-HyA was safe and the reduction of hemarthrosis episodes after 12 months was higher compared to patients treated with [ 90 Y]HyA (87.5% vs 50%), especially in adults/ adolescents.…”

Section: Osteoarthritis: Radiosynovectomymentioning

confidence: 99%

Present and future of target therapies and theranostics: refining traditions and exploring new frontiers—highlights from annals of Nuclear Medicine 2021

Pini

Gelardi

Sollini

2022

Eur J Nucl Med Mol Imaging

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Radiosynoviorthesis: almost seventy years of experience but still somewhat fameless

Zant¹,

Knol²,

Broos³

2022

Q J Nucl Med Mol Imaging

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Knee radiosynovectomy with 153Sm-hydroxyapatite compared to 90Y-hydroxyapatite: initial results of a prospective trial

Cited by 3 publications

References 26 publications

Radiosynovectomy in haemophilic synovitis and arthropathy of the knee: A scoping review

Radiosynovectomy in haemophilic synovitis and arthropathy of the knee: A scoping review

Present and future of target therapies and theranostics: refining traditions and exploring new frontiers—highlights from annals of Nuclear Medicine 2021

Radiosynoviorthesis: almost seventy years of experience but still somewhat fameless

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