Knockdown of hsa_circ_0043691 restrains the progression of gastric cancer by decoying miR‐1294 to target pre‐leukemia transcription factor 3

Abstract

As the most frequent malignant tumor, gastric cancer (GC) is a major cause of tumor-related death. 1,2 Because of the unconspicuous early symptoms, many GC patients were diagnosed at advanced stages. 3 Although GC can be treated by surgical resection in the clinic, its invasive metastasis greatly increased the difficulty of operation. 4 Thus, it is imperative to investigate the underlying molecular mechanism of GC genesis and progression and develop a new therapeutic regimen.Circular RNA (circRNAs) are characterized by the closed-loop structure and the absence of 5′heads or 3′polyadenylated tail, 5 which made them more stable and resistant to the degradation of exonuclease. 6 Due to the superior characteristics of circRNA, it was found to exert vital effects in the research of new tumor biomarkers. 7 Currently, multiple circRNAs have been found to play an important role in regulating the progress of cell biology in various human diseases. 8,9 Consequently, circRNAs may be promising biomarkers for the management of diverse human diseases.