Knockdown of Litopenaeus vannamei HtrA2, an up-regulated gene in response to WSSV infection, leading to delayed shrimp mortality

Peepim, Termsri; Phiwsaiya, Kornsunee; Charoensapsri, Walaiporn; Khunrae, Pongsak; Senapin, Saengchan; Rattanarojpong, Triwit

doi:10.1016/j.jbiotec.2015.12.019

Cited by 5 publications

(2 citation statements)

References 55 publications

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“…Knocking down of HtrA2 encoding gene in L. vannamei had delayed the death of a shrimp when infected with a low dose of WSSV. This indicates the role of HtrA2 in shrimp pathogenesis rather than protection against the viral infection [42]. Furthermore, investigation of the expression level of Pm caspase and PmIAP after WSSV infection in P. monodon was found to remain unchanged [27].…”

Section: Bir2 Domain Of Pmiap Inhibits Pm Caspase Activitymentioning

confidence: 95%

The interaction between PmHtrA2 and PmIAP and its effect on the activity of Pm caspase

Saleeart

Mongkorntanyatip

Sangsuriya

et al. 2016

Fish & Shellfish Immunology

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Section: Bir2 Domain Of Pmiap Inhibits Pm Caspase Activitymentioning

confidence: 95%

The interaction between PmHtrA2 and PmIAP and its effect on the activity of Pm caspase

Saleeart

Mongkorntanyatip

Sangsuriya

et al. 2016

Fish & Shellfish Immunology

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“…Protein profiles have been also investigated to find the responding mechanisms of L. vannamei to viral infections (Wang et al, 2007; Chen et al, 2016). Recently, several genes, such as LvHtrA2 (Peepim et al, 2016), LvVEGF1 and LvVEGF2 (Wang Z. et al, 2015), were found to have an association with viral infections. However, current researches mainly focused on the response of genes and proteins against infection, but ignoring the interactions between genes and proteins.…”

Section: Introductionmentioning

confidence: 99%

The Protein–Protein Interaction Network of Litopenaeus vannamei Haemocytes

Hao¹,

Zhao²,

Wu³

et al. 2019

Front. Physiol.

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Protein–protein interaction networks (PINs) have been constructed in various organisms and utilized to conduct evolutionary analyses and functional predictions. Litopenaeus vannamei is a high-valued commercial aquaculture species with an uncharacterized interactome. With the development of RNA-seq techniques and systems biology, it is possible to obtain genome-wide transcriptional information for L. vannamei and construct a systematic network based on these data. In this work, based on the RNA-seq of haemocytes we constructed the first L. vannamei PIN including 4,858 proteins and 104,187 interactions. The PIN constructed here is the first large-scale PIN for shrimp. The confidence scores of interactions in the PIN were evaluated on the basis of sequence homology and genetic relationships. The immune-specific sub-network was extracted from global PIN, and more than a third of proteins were found in signaling pathways in the sub-network, which indicates an inseparable relationship between signaling processes and immune mechanisms. Six selected signaling pathways were constructed at different age groups based on evolutionary analyses. Furthermore, we showed that the functions of the pathways’ proteins were associated with their evolutionary history based on the evolutionary analyses combining with protein functional analyses. In addition, the functions of 1,955 unclassified proteins which were associated with 3,191 unigenes were assigned using the PIN, which account for approximately 70.3 and 44.9% of the previously unclassified proteins and unigenes in the network, respectively. The annotation of unclassified proteins and unigenes based on the PIN provides new candidates for further functional studies. The immune-specific sub-network and the pathways extracted from the PIN provide a novel information source for studying of immune mechanisms and disease resistances in shrimp.

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Ageing reduces the reproductive performance of male white shrimp Litopenaeus vannamei by altering sperm intracellular Ca2+ concentrations and interfering with sperm apoptosis

Shi

Zha

et al. 2018

Animal Reproduction Science

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Knockdown of Litopenaeus vannamei HtrA2, an up-regulated gene in response to WSSV infection, leading to delayed shrimp mortality

Cited by 5 publications

References 55 publications

The interaction between PmHtrA2 and PmIAP and its effect on the activity of Pm caspase

The interaction between PmHtrA2 and PmIAP and its effect on the activity of Pm caspase

The Protein–Protein Interaction Network of Litopenaeus vannamei Haemocytes

Ageing reduces the reproductive performance of male white shrimp Litopenaeus vannamei by altering sperm intracellular Ca2+ concentrations and interfering with sperm apoptosis

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