2023
DOI: 10.1242/jcs.261199
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Knockout of all ErbB-family genes delineates their roles in proliferation, survival and migration

Abstract: The ErbB-family receptors play pivotal roles in the proliferation, migration, and survival of epithelial cells. Because our knowledge on the ErbB-family receptors was obtained largely by the exogenous application of their ligands, it remains unknown to which extent each of the ErbB contributes to these outputs. We here knocked out each ErbB gene, various combinations of ErbB genes, or all in Madin-Darby canine kidney cells to delineate the contribution of each gene. ERK activation waves during collective cell … Show more

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Cited by 4 publications
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