Knockout of GGPPS1 restrains rab37-mediated autophagy in response to ventilator-induced lung injury

Wang, Zexu; Chen, Meizi; Pan, Xia; Wang, Li; Yin, C. Cameron; Qi, Lin; Jiang, Jingjing; Zhang, Yunlei; Wan, Bing

doi:10.1007/s13577-022-00692-7

Cited by 4 publications

(1 citation statement)

References 41 publications

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“…The researches of GGPS1 on the functions and the relationship between diseases and GGPS1 involve an extremely extensive range. GGPS1-knockout plays a part in restraining ventilator-induced lung injury and attenuating sepsis-induced acute lung injury (Li et al, 2021;Wang et al, 2022). In Perrault syndrome and A typical femur fractures, GGPS1 may be one of the genetic factors (Foley et al, 2020;Zhou et al, 2021;Faridi et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

The prognostic role and metabolic function of GGPS1 in oral squamous cell carcinoma

Huang

Han

et al. 2023

Front. Mol. Biosci.

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Background: GGPS1(geranylgeranyl diphosphate synthase 1) is a member of the prenyltransferase family. Abnormal expression of GGPS1 can disrupt the balance between protein farnesylation and geranylgeranylation, thereby affecting a variety of cellular physiologic and pathological processes. However, it is still unknown how this gene could contribute to the prognosis of oral squamous cell carcinoma (OSCC). This study aimed to explore the prognostic role of GGPS1 in OSCC and its relationship with clinical features.Methods: The RNA-seq data and clinical data were obtained from TCGA. The survival analyses, Cox regression analyses, ROC curves, nomograms, calibration curves, and gene function enrichments were established by R software.Results: The results showed that the high expression of GGPS1 in OSCC is related to poor prognosis. At the same time, multivariate Cox regression analyses showed that GGPS1 could be an independent prognostic biomarker, and its gene expression level is closely related to the histological stage of cancer. GGPS1 may promote tumorigenesis because of its metabolic function.Conclusion: This study came to a conclusion that GGPS1, whose high expression has a significantly unfavorable meaning toward the prognosis of OSCC, can act as a novel independent biomarker for OSCC.

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