Back ground: - Long-acting contraception method utilization was found low (22.7%) among female health care providers. However, as far as my literature search no study was done on long-acting contraception methods utilization among female health providers in the study area. These studies failed to include important variable like socio demography and individual factor which might affect the use of long-acting contraceptive methods female health providers and limited studies in Ethiopia. Objective: - To assessing utilization of long -acting contraceptive methods and associated factors among health care providers in south wollo zone public hospitals, Amhara region, Ethiopia 2021.Methods: -An Institutional-based cross- sectional was conducted among 354 female health care workers in south wollo zone hospitals, from March to April 22, 2021. The participants were selected using Systematic random sampling technique. Data were collected by using self-administered questionnaire. The data were entered Epi-data version 4.1 and export to SPSS versions 25 for analysis. Bivariable and multivariable logistic regression analysis were performed. The Adjusted odds Ratio (AOR) along with a 95% confidence interval (CI) was estimated to measure the association and level of significance was declared at a P- value of less than 0.05.Result: -The current utilization of long-acting contraceptive methods among female health care providers was found to be 33.6% [95%, CI 29-39)], discuss with partner [AOR= 2.277,95% CI, (1.026-5.055)], method shift/switched [AOR=4.302,95% CI, (2.285-8.102)], knowledge of respondent [AOR= 1.887,95% CI, (1.020-3.491)], ever birth [AOR=15.670,95% CI, (5.065-48.49)] were significant factors towards the utilization of long-acting contraceptive methods. Conclusion and recommendation: -The current utilization of long-acting contraceptive methods was found low. Discus with partner, methods shift/switching, ever birth and knowledge of respondents were identified as significant factor. Therefore, encouraging partner discussion targeted Information Education Communication Intervention should be intensified to improve long-acting contraceptive methods utilization.