Knowledge sharing (KS) is a critical factor in both governmental and nongovernmental organizations. The synthesis of KS literatures reveals different factors (i.e., employees' creativity; support of top management; and trust among employees, formalization, centralization, and technology infrastructure) of organizational culture, structure, and Infrastructure. This study investigates the influence of these factors on KS. A questionnaire has been developed to collect data. The population of this study consists of all special education centers in Jordan, resulting in (195) individual questionnaires for data analysis. The questionnaire was shown to be reliable and valid.Subsequently, relevant statistical analysis has been carried out. The results show that organizational structure factors (i.e., formalization, centralization, and technology infrastructure) are significant and have a strong influence on KS whereas organizational culture factors (i.e., employees' creativity, support of top management, and trust among employees) are insignificant and have a negative influence on KS at the surveyed centers.