Knowledge of endometrial cancer risk factors in a general gynecologic population

Washington, Christina; Haggerty, Ashley; Ronner, Wanda; Neff, P.; Ko, Emily

doi:10.1016/j.ygyno.2020.03.032

Cited by 20 publications

(21 citation statements)

References 19 publications

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“…Based on a meta-analysis of survey response rates (Shih & Fan, 2008), web-based surveys are associated with significantly lower response rates as compared to other modes of delivery. Our response rate was consistent with previous studies in gynecologic patient populations, particularly as related to studies of cancer risk (Shih & Fan, 2008;Washington et al, 2020). Although we were unable to compare responders and nonresponders in the present study due to participant anonymity across sites, responders may be more open about BRCA1and BRCA2-related health concerns and family planning than nonresponders.…”

Section: Discussionsupporting

confidence: 87%

Family planning in carriers of BRCA1 and BRCA2 pathogenic variants

Haddad

Robison

Beffa

et al. 2021

Journal of Genetic Counseling

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BRCA1 and BRCA2 pathogenic variant carriers have a high lifetime risk of developing breast and ovarian malignancies. Given the risks and significant ramifications of undergoing risk-reducing surgeries, many pathogenic variant carriers unaffected by cancer (previvors) struggle with family planning and reproductive decision making. The objective of this study was to determine the attitudes and practices of BRCA1 and BRCA2 pathogenic variant carriers with respect to family planning decision making. A cross-sectional survey was conducted of BRCA1 and BRCA2 previvors at four Northeastern medical centers. The survey was administered electronically via email using REDCap. The survey included demographic information as well as questions about genetic testing, prophylactic surgeries, family planning, and partnering. Data were analyzed with Fisher's exact tests and t tests. The survey was completed by 139 of 422 BRCA1 and BRCA2 pathogenic variant carriers (response rate 33%). Thirteen were excluded from analysis due to self-reported cancer history. Of the remaining 126, 21 (16.7%) were male and 105 (83.3%) were female. Female participants <35 years old at the time of genetic testing were significantly more likely than those 35 or greater to report feeling urgency to have a family after finding out about their BRCA1 and BRCA2 pathogenic variant (p < 0.0001). Younger women also reported their genetic status had a stronger impact on their romantic relationships (p = 0.029). Men were significantly more likely to report that they felt no urgency to have a family compared to women (p < 0.0001). Our study reflects the complex decision making for previvors and the intricacies of family planning in this population. Providers can use this knowledge as a guide to counsel patients about reproductive options.

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Section: Discussionsupporting

confidence: 87%

Family planning in carriers of BRCA1 and BRCA2 pathogenic variants

Haddad

Robison

Beffa

et al. 2021

Journal of Genetic Counseling

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“…Few previous studies have explored women’s understanding of the relationship between obesity and endometrial cancer risk. Two studies from the USA found 58% of 1545 women from the general population 20 and 52% of 231 gynecology clinic attendees, 21 respectively, were not aware that obesity increases the risk of endometrial cancer. Participant BMI did not impact awareness in either study.…”

Section: Discussionmentioning

confidence: 99%

“…According to models of health behavior, knowledge of risk factors and perceived personal risk, alongside beliefs about the ability to change that risk, are important factors that influence a person’s capability and motivation to change their behavior. 19 Previous work has shown that public awareness of the link between obesity and endometrial cancer risk is low, 20 , 21 but no studies have asked women whether they are interested in reducing their endometrial cancer risk and what interventions would be acceptable to them. The aim of this study was to assess the willingness of women at greatest risk of obesity-related endometrial cancer to engage in risk-reducing strategies and to establish any barriers that may prevent their participation in a randomized controlled trial of primary prevention.…”

Section: Introductionmentioning

confidence: 99%

Women’s Risk Perceptions and Willingness to Engage in Risk-Reducing Interventions for the Prevention of Obesity-Related Endometrial Cancer

Derbyshire¹,

MacKintosh²,

Pritchard³

et al. 2022

IJWH

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Introduction Endometrial cancer rates are rising in parallel with the global obesity epidemic. Our aim was to assess the willingness of women at greatest risk of obesity-related endometrial cancer to engage with risk-reducing strategies and establish perceived barriers that may preclude their participation in a randomized controlled trial of primary endometrial cancer prevention. Materials and Methods Women attending gynecology, obesity and sleep apnea clinics in Manchester Academic Health Sciences Centre-affiliated hospitals with obesity classes II (BMI 35–39.9kg/m 2 ) and III (BMI ≥40kg/m 2 ) were invited to participate in a cross-sectional survey. We asked women about their perceived risk, knowledge of risk factors and willingness to engage with endometrial cancer risk-reducing interventions. Results Seventy-four women with a median age of 51 years (range 22–73) and BMI of 47kg/m 2 (range 34–81) took part in the study. Two-thirds (65.6%) knew that obesity was a risk factor for endometrial cancer but few were able to recall other major risk factors. Just over half (53.5%) perceived their risk of developing endometrial cancer to be higher than average. Women were prepared to lose weight (94%), eat healthily (91%), exercise more (87%), take a pill every day (74%) or receive an intra-uterine device (49%) for primary endometrial cancer prevention. Perceived barriers included cost, forgetting, willpower, finding time, physical fitness, social anxiety, possible side effects and previous bad experiences. Conclusion Women at highest risk of obesity-related endometrial cancer may not always appreciate their susceptibility. However, willingness to engage in risk-reducing strategies suggests recruitment to a randomized controlled trial for primary endometrial cancer prevention could be feasible.

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“…EC is the most popular malignancy in gynecological cancers, and the malignant tumor is associated with obesity 23 . The excess of estrogen causes EC, insulin resistance, and inflammation-driven by obesity, and the incidence rate of EC has been increasing in parallel with obesity 24 .…”

Section: Discussionmentioning

confidence: 99%

Modulation of Tumor Microenvironment through Aurea Helianthus Extract and Induced Exosomes

Park¹,

Lee²,

Kim³

et al. 2020

Preprint

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Endometrial cancer (EC) cells metastasize to various regions, including ovaries, fallopian tubes, cervix, blood, liver, bone, and brain. Various carcinogens cause EC. Exosomes are released from several types of cells and contain different components depending on cellular types. Although tocopherol- α and rutin were high components in Aurea helianthus, the Aurea elianthus extract was enormously useful in modulating tumor microenvironment contrasted to the two substances. Notably, we established that the extract induced bioactive exosomes in EC cells, and profiling of miRNAs in the extract inducing exosomes (EIE) present potency to develop a biological drug. The extract and EIE contributed to the following five biological categories for EC cells: (1) suppressed migration and invasion; (2) activated cellular senescence by attenuating mitochondrial membrane potential and enhancing autophagy; (3) attenuated eproductive cancer activity; (4) activated drug susceptibility; and (5) EIE contained miRNA associated with decreasing inflammation.

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Knowledge of endometrial cancer risk factors in a general gynecologic population

Cited by 20 publications

References 19 publications

Family planning in carriers of BRCA1 and BRCA2 pathogenic variants

Family planning in carriers of BRCA1 and BRCA2 pathogenic variants

Women’s Risk Perceptions and Willingness to Engage in Risk-Reducing Interventions for the Prevention of Obesity-Related Endometrial Cancer

Modulation of Tumor Microenvironment through Aurea Helianthus Extract and Induced Exosomes

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