Multi-project organizations regularly appeal to project coupling - defined as human resources relocation across simultaneous or consequent comparable projects - as a mean of knowledge transfer. This fact requires identifying the managerial context and parameters of project coupling as this decision is linked to project comparisons and project knowledge cycles. The aim of this paper consist in proposing a managerial framework for a systematic guidance of project coupling decisions. As a result of the current research the framework proposed is one operating against the background of an organizational commitment to retention of successful team members and to adequate project reviews. The framework takes into account two categories of guiding criteria for project coupling decisions: the need for project comparisons (in terms of scope, knowledge deliverables and stakeholder networks) and, on the other hand, a dynamic tridimensional (biographical, baseline compliant, relational) knowledge profile of project team members.