Kodamaea ohmeri tricuspid valve endocarditis with right ventricular inflow obstruction in a neonate with structurally normal heart

Sundaram, Ponnusamy Shunmuga; Sasidharan, Bijulal; Tharakan, Jaganmohan A.; Antony, Molly

doi:10.4103/0974-2069.79632

Cited by 26 publications

(16 citation statements)

References 8 publications

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“…The infection was often serious and fatal (attributable mortality 31.8%). Kodamaea ohmeri is rarely reported to cause human infection . Before the present report, only 39 cases of K. ohmeri infection had been reported.…”

Section: Discussionmentioning

confidence: 70%

“…The clinical importance of other Kodamaea species (K. anthrophila, K. kakaduensis, K. laetipori K. nitidulidarum) is not known [10]. Kodamaea ohmeri is reported to cause high mortality (50%) in paediatric populations [11][12][13][14][15][16][17][18][19][20][21]. From our tertiary care centre with 1740 beds we report a very high incidence of fungaemia (300-500 cases every year) and C. tropicalis is the commonest isolate [8,[22][23][24].…”

Section: Introductionmentioning

confidence: 91%

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Epidemiological study of a large cluster of fungaemia cases due to Kodamaea ohmeri in an Indian tertiary care centre

Chakrabarti¹,

Rudramurthy²,

Kale³

et al. 2014

Clinical Microbiology and Infection

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While performing molecular confirmation of phenotypically identified Candida tropicalis isolates, we re-identified a few isolates as Kodamaea ohmeri. This led us to the present epidemiological investigation of K. ohmeri fungaemia cases. All phenotypically identified C. tropicalis blood isolates during October 2008 through to December 2009 at our advanced paediatric centre were included for molecular identification by sequencing of the internal transcribed spacer and D1/D2 regions of rDNA. After identifying a large cluster K. ohmeri fungaemia cases, a case-control study was carried out retrospectively to analyse potential risk factors for K. ohmeri fungaemia. Molecular typing of the isolates was performed using a fluorescent amplified fragment length polymorphism (FAFLP) technique. The antifungal susceptibility testing was performed as per the M27-A3 protocol of CLSI. Thirty-eight (25.7%) of 148 phenotypically identified C. tropicalis isolates were confirmed as K. ohmeri by sequencing and FAFLP. By case-control analysis, piperacillin-tazobactam was significantly associated with the K. ohmeri fungaemia. The FAFLP analysis showed that all K. ohmeri isolates had >92% similarity. The azoles and echinocandins had good in vitro activity against K. ohmeri, though 86.8% of the isolates had MIC of 1 mg/L for amphotericin B. The response to antifungal therapy could be evaluated in 27 patients and 70.4% of patients recovered after antifungal therapy. The present study reports the largest cluster of K. ohmeri fungaemia from a single centre. The study also stresses the need for accurate identification of clinical yeast isolates.

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Section: Discussionmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 91%

Epidemiological study of a large cluster of fungaemia cases due to Kodamaea ohmeri in an Indian tertiary care centre

Chakrabarti¹,

Rudramurthy²,

Kale³

et al. 2014

Clinical Microbiology and Infection

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“…No additional studies were found during the hand‐screening of the included articles' references. Finally, 35 met the present study's inclusion criteria 3,4,7–39 . The review process is graphically presented in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

Kodamaea ohmeri infections in humans: A systematic review

Ιωάννου

Papakitsou

2020

Mycoses

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Summary Background Kodamaea ohmeri, previously known as Pichia ohmeri or Yamadazyma ohmeri, belongs to the Saccharomycetaceae family and the Ascomycetae class, is the telomorphic form of C guilliermondii var. membranaefaciens and is frequently mistaken for Candida, as they belong to the same family. It has been isolated from environmental sources, such as sand, pools, seawater and fruits, while the last decades it is recognised as a rare pathogen that causes life‐threatening infections in humans. The purpose of this study was to systemically review all published cases of K ohmeri infections in the literature and describe the epidemiology, microbiology, antimicrobial susceptibility, treatment and outcomes of these infections in humans. Methods Systematic review of PubMed (through 27th December 2019) for studies providing epidemiological, clinical, microbiological as well as treatment data and outcomes of K ohmeri infections. Results A total of 35 studies, containing data of 44 patients, were included in the analysis. The most common K ohmeri infections were those of the bloodstream, infective endocarditis and onychomycosis. Previous antibiotic use, presence of a central venous catheter, parenteral nutrition and cancer were very common among patients. Mortality was high in the case of fungemias but low for other types of infections. Amphotericin B and fluconazole are the most common agents used for treatment, even though alarming MICs for fluconazole were noted. Conclusions This systematic review thoroughly describes infections by K ohmeri and provides information on their epidemiology, clinical presentation, microbiology, antibiotic resistance patterns, treatment and outcomes.

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“…Introduction Kodamaea (Pichia) ohmeri is a rarely occurring yeast that has recently been identified as a cause of fungaemia, endocarditis, cellulitis, funguria and peritonitis in neonates and children [83][84][85][86][87], and in both immunocompromised [88][89][90][91] and immunocompetent [92,93] [94] by traditional methods and molecular identification is mandatory.…”

Section: Kodamaea Ohmerimentioning

confidence: 99%

“…Kodamaea ( Pichia ) ohmeri is a rarely occurring yeast that has recently been identified as a cause of fungaemia, endocarditis, cellulitis, funguria and peritonitis in neonates and children , and in both immunocompromised and immunocompetent adult patients. The anamorphic state is Candida guilliermondii var .…”

Section: Introductionmentioning

confidence: 99%

ESCMID and ECMM joint clinical guidelines for the diagnosis and management of rare invasive yeast infections

Arendrup

Boekhout

Akova

et al. 2014

Clinical Microbiology and Infection

432

396

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The mortality associated with invasive fungal infections remains high with that involving rare yeast pathogens other than Candida being no exception. This is in part due to the severe underlying conditions typically predisposing patients to these healthcare-related infections (most often severe neutropenia in patients with haematological malignancies), and in part due to the often challenging intrinsic susceptibility pattern of the pathogens that potentially leads to delayed appropriate antifungal treatment. A panel of experts of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Fungal Infection Study Group (EFISG) and the European Confederation of Medical Mycology (ECMM) undertook a data review and compiled guidelines for the diagnostic tests and procedures for detection and management of rare invasive yeast infections. The rare yeast pathogens were defined and limited to the following genera/species: Cryptococcus adeliensis, Cryptococcus albidus, Cryptococcus curvatus, Cryptococcus flavescens, Cryptococcus laurentii and Cryptococcus uniguttulatus (often published under the name Filobasidium uniguttulatum), Malassezia furfur, Malassezia globosa, Malassezia pachydermatis and Malassezia restricta, Pseudozyma spp., Rhodotorula glutinis, Rhodotorula minuta and Rhodotorula mucilaginosa, Sporobolomyces spp., Trichosporon asahii, Trichosporon asteroides, Trichosporon dermatis, Trichosporon inkin, Trichosporon jirovecii, Trichosporon loubieri, Trichosporon mucoides and Trichosporon mycotoxinivorans and ascomycetous ones: Geotrichum candidum, Kodamaea ohmeri, Saccharomyces cerevisiae (incl. S. boulardii) and Saprochaete capitatae (Magnusiomyces (Blastoschizomyces) capitatus formerly named Trichosporon capitatum or Geotrichum (Dipodascus) capitatum) and Saprochaete clavata. Recommendations about the microbiological investigation and detection of invasive infection were made and current knowledge on the most appropriate antifungal and supportive treatment was reviewed. In addition, remarks about antifungal susceptibility testing were made.

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Kodamaea ohmeri tricuspid valve endocarditis with right ventricular inflow obstruction in a neonate with structurally normal heart

Cited by 26 publications

References 8 publications

Epidemiological study of a large cluster of fungaemia cases due to Kodamaea ohmeri in an Indian tertiary care centre

Epidemiological study of a large cluster of fungaemia cases due to Kodamaea ohmeri in an Indian tertiary care centre

Kodamaea ohmeri infections in humans: A systematic review

ESCMID and ECMM joint clinical guidelines for the diagnosis and management of rare invasive yeast infections

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