Kojic acid applications in cosmetic and pharmaceutical preparations

Saeedi, Majid; Eslamifar, Masoumeh; Khezri, Khadijeh

doi:10.1016/j.biopha.2018.12.006

Cited by 301 publications

(245 citation statements)

References 140 publications

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“…In some tropical areas, maximum exposure of skin to sunlight can result in an elevated risk that leads to skin cancer, oxidative stress, and sunburn 21 . To prevent the hazardous cause of ultraviolet rays, kojic acid isolated from fungi has been used in many cosmetic creams, lotions, and soaps because they prevent hyperpigmentation and tyrosinase inactivity, it is also used to avoid food browning 22 .…”

Section: Introductionmentioning

confidence: 99%

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An In vitro Approach for Evaluating Antimicrobial Activity and Production of Kojic Acid by Aspergillus flavus Isolated from Karwar Region

Sanjotha¹,

Shivasharana²,

Manawadi³

2019

J Pure Appl Microbiol

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Section: Introductionmentioning

confidence: 99%

“…Hence kojic acid and its derivatives have developed huge applications in medicine, Pharmaceutical industries, agricultural, chemical and food industries 22 . Along with kojic acid, its derivatives are also found to enhance solidity and solubilizing nature of kojic acid in various oily creams in the cosmetic industry [23][24][25][26] .…”

Section: Introductionmentioning

confidence: 99%

An In vitro Approach for Evaluating Antimicrobial Activity and Production of Kojic Acid by Aspergillus flavus Isolated from Karwar Region

Sanjotha¹,

Shivasharana²,

Manawadi³

2019

J Pure Appl Microbiol

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“…We found that the cell line was productively smothered by KGO, as shown in Figure 1 B. In both of these analyses, we used kojic acid as our positive control, as kojic acid is a well-known brightening agent [ 14 ].…”

Section: Resultsmentioning

confidence: 99%

Anti-Melanogenic Effects of Korean Red Ginseng Oil in an Ultraviolet B-Induced Hairless Mouse Model

et al. 2020

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A ‘remedy for all’ natural product widely known in the Korean Peninsula is called Panax Ginseng Meyer. Globalization represents a persistent risk to the ozone layer, leading to bountiful amounts of Ultra-Violet B beams (UVB). The variety in human skin hues is ascribed to the characteristic color called Melanin. However, Melanin overproduction due to UVB beams promotes skin staining and tumorigenesis, a process called photo aging, which damages skin quality. To assess the effects of Korean Red Ginseng Oil (KGO) on photo aging, the murine melanoma cell lines B16/F10 were used in vitro and HRM-2 hairless mice exposed to UVB were studied in vivo. Our results revealed that KGO reduced tyrosinase activity and melanin production in B16/F10 cells along with the suppression of upstream factors involved in the melanin production pathway, both transcriptionally and transitionally. In the in vivo studies, KGO suppressed the expression of Matrix Metalloproteinase (MMP) and Interleukins along with a reduction of depth in wrinkle formation and reduced collagen degradation. Moreover, the feed intake and feed efficiency ratio that decreased as a result of UVB exposure was also improved by KGO treatment. In light of our results, we conclude that KGO can have considerable benefits due to its various properties of natural skin enhancement.

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“…Naringin is effective at protecting against the development of metabolic syndrome as it changes the expression The values in brackets represent the blood glucose percentage changes compared to the initial glycemia; The average percentage changes followed by different letters (a, b, c) in the same column are significantly different at 5% level; h: hour; min: minute; AEF: Aqueous extract of the formulation; AES: Aqueous extract of Salvia officinalis; n: number of animals of hepatic genes involved in lipid metabolism and gluconeogenesis via their up-regulation (Vinayagam and Xu, 2015). Concerning phenolic acids (Caffeic, Chlorogenic, Protocatechuic, p-Coumaric, Cinnamic, Gallic, Syringic, Ferulic, Salicylic) and Kojic acid, an anti-diabetic activity has been reported (Vinayagam and Xu, 2015;Amadi et al, 2016;Saeedi et al, 2019).…”

Section: Identification and Quantification Of Phenolic And Heterocyclmentioning

confidence: 99%

Hypoglycaemic activity of preheated (roasting) Aframomum citratum (C. Pereira) K. Schum and Tetrapleura tetraptera (Schumach Thonn.) fruits beverage on Streptozotocin-induced rats

Eyenga¹,

Takuissu²,

Ziyyat³

et al. 2020

J. Pharmacognosy Phytother.

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Tetrapleura tetraptera and Aframomum citratum fruits are used as spices and in the traditional pharmacopeia in Cameroon. They are mostly combined and preheated for many purposes while cooking. The effects of roasting on the phenolic content of spices, phenolic profile of a beverage made with the mix of roasted spices and its hypoglycaemic activity on diabetes complications were investigated. Aqueous extract (infusion: 100°C; 1/5 g/ml) was prepared, and the total polyphenols and flavonoids contents before and after heat treatment were quantified. Four formulations of T. tetraptera/A. citratum (95/5; 90/10; 85/15; 80/20) were assessed and the in vitro glucose adsorption capacity of the extracts was studied to retain the most effective formulation (AEF). Phenolic and derivatives compounds of AEF were analysed using HPLC-DAD methodology. The AEF hypoglycaemic activity (250 mg/kg bw) and the various complications of hyperglycaemia after Streptozotocin induction (55 mg/kg) were examined on rats. Significant (p<0.05) improvements in phytochemical content were noticed for T. tetraptera and AEF extracts after heat treatment. Among the phenolic compounds identified, flavone, protocatechic, chlorogenic, p-Coumaric acids, and naringin showed the highest concentrations. Significantly, the effect of AEF is the same as the administration of AEF-Glibenclamide (Glibenclamide) and Acarbose after 4 h when assessing the anti-hyperglycaemic test. The influence of Glibenclamide (the reference drug) is significantly improved by AEF, and this synergy has the best antihyperglycaemic, hypoglycaemic, hypotriglyceridaemic potential and boosts catalase, superoxide dismutase activities while reducing Malondialdehyde (liver, pancreas, haemolysates) and hydroperoxide (liver, plasma, and kidney) contents compared with the use of single AEF.

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Kojic acid applications in cosmetic and pharmaceutical preparations

Cited by 301 publications

References 140 publications

An In vitro Approach for Evaluating Antimicrobial Activity and Production of Kojic Acid by Aspergillus flavus Isolated from Karwar Region

An In vitro Approach for Evaluating Antimicrobial Activity and Production of Kojic Acid by Aspergillus flavus Isolated from Karwar Region

Anti-Melanogenic Effects of Korean Red Ginseng Oil in an Ultraviolet B-Induced Hairless Mouse Model

Hypoglycaemic activity of preheated (roasting) Aframomum citratum (C. Pereira) K. Schum and Tetrapleura tetraptera (Schumach Thonn.) fruits beverage on Streptozotocin-induced rats

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