Kollisionstumor eines adenoidzystischen Karzinoms des Hypopharynx und eines Plattenepithelkarzinoms des Larynx

Abstract

Immunohistochemical characteristics showed two different carcinoma entities in the larynx and hypopharynx. Only by complete histological investigation of a carcinoma those rare cases of a collision tumor can be detected. Both tumor entities need to be considered for therapy strategy and oncological follow-up planning.

Collision carcinoma of squamous cell carcinoma and small cell neuroendocrine carcinoma of the larynx: A case report and review of the literature

“…The definition of collision carcinoma is controversial, with different researchers having different interpretations. Some believe that collision carcinoma can occur in adjacent organs, and that the tumors can eventually invade each other[6-8]. Kufeld et al[6] reported a case of collision carcinoma of hypopharyngeal adenoid cystic carcinoma and laryngeal SCC.…”

“…Some believe that collision carcinoma can occur in adjacent organs, and that the tumors can eventually invade each other[6-8]. Kufeld et al[6] reported a case of collision carcinoma of hypopharyngeal adenoid cystic carcinoma and laryngeal SCC. Marangoni et al[7] reported carcinomas colliding in the aryepiglottic fold of hypopharyngeal SCC and laryngeal NEC.…”

“…Jacobson et al[8] reported a case of papillary thyroid carcinoma and laryngeal SCC. They suggested that this was a case of collision carcinoma[6-8]. Some researchers have posited that a benign tumor and a malignant tumor, or two benign tumors, occurring in one organ at the same time can also be considered as collision carcinoma[9].…”

“…We suggest the following: collision carcinoma should be considered only when there are two malignant tumors that look like a mass to the naked eye and originate from the same organ, but are of different pathological types and with neither tumor having migrated to the other[2,12]. Organs in the head and neck region are adjacent to each other; thus it is easy to misidentify tumors that originate from different organs and eventually invade each other at the same location as collision carcinoma[6-8]. We prefer to call these tumors multiple primary carcinomas[13].…”

“…It has been reported that the 2- and 5-year survival rates of SCNEC are 16% and 5%, respectively[33]. SCNEC has a rapid growth rate and high metastatic potential; approximately 50% of patients have positive regional lymph nodes and more than two-thirds present with distant metastases, most frequently to cervical lymph nodes, liver, lungs, bones, and bone marrow[6,28,34]. According to the National Comprehensive Cancer Network Guidelines of Neuroendocrine Tumors (ver.…”