Kombic acid, a hydroquinone polyisoprenoic carboxylic acid from Pycnanthus kombo seed fat

Lok, Chun‐Nam; Groenewegen, A.; Stroink, J. B. A.; Ward, J. P.

doi:10.1016/0031-9422(83)80026-0

Cited by 14 publications

(15 citation statements)

References 3 publications

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“…An oxidized derivative of 5, kombic acid (6), has been reported from the seed fat of Pycnanthus kombo. 16 We were unsuccessful at detecting 6 in P. angolensis; however, we did isolate and characterize sargachromenol (7), 24 which is also presumably derived from 5.…”

Section: Resultsmentioning

confidence: 96%

“…10 Other reported ethnomedical indications in the literature include its use as an anthelmintic, 11 a treatment for cough and sore throat, 12 and for the treatment of rheumatism and hemorrhoids. 13 Despite these reports, the genus Pycnanthus has not been extensively investigated, and the only compounds reported include allantoin, 14 flavonoids, 15 kombic acid, 16 and dihydroguaiaretic acid. 17 We now report the isolation and identification of two new compounds from the extracts of leaves and stems of P. angolensis, pycnanthuquinone A (1) and pycnanthuquinone B (2).…”

Section: Introductionmentioning

confidence: 96%

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Novel Antihyperglycemic Terpenoid-Quinones from Pycnanthus angolensis

et al. 2000

J. Org. Chem.

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Two new compounds, pycnanthuquinone A (1) and pycnanthuquinone B (2), were isolated from leaves and stems of the African plant, Pycnanthus angolensis (Welw.) Warb (Myristicaceae), by bioassay-guided fractionation of an ethanolic extract using a diabetic mouse model. Pycnanthuquinones A and B are the first representatives of a novel terpenoid-type quinone skeleton, and both compounds possess significant antihyperglycemic activity.

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Section: Resultsmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 96%

Novel Antihyperglycemic Terpenoid-Quinones from Pycnanthus angolensis

et al. 2000

J. Org. Chem.

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“…and Thonn) Taub. (12117/SRFCam) Tonic, purgative, emetic, convulsions, leprosy, anti-inflammatroy, rheumatic pains (Dalziel, 1948;Ojewole and Adesina, 1983;Oliver-Bever, 1983 (Keay et al, 1964;Lok et al, 1983;Omobuwajo et al, 1992;Akendengué and Louis, 1994;Fort et al, 2000;Wabo et al, 2007;Abrantes et al, 2008) Bark leaves, root, wood Leaves (19.76) Antihelmintic and anticancer: dihydroguaiaretic acid (Abrantes et al, 2008), Antihyperglycemic: pycnanthuquinones A and B (Luo et al, 1999;Fort et al, 2000;Gbolade and Adeyemi, 2008), Antimicrobial: pycnanthulignene A pycnanthulignene C 3,4-dimethoxy-3 ,4 -methylenedioxy-7,7 -epoxylignan; genkwainin; pycnanthulignene C; 4,5-dimethoxy-3 ,4 -methylenedioxy-2,7 -cycloligna-7,7 -diene; pycnanthulignene A; calycosin; biochanin A; prunetin …”

Section: Whole Plantmentioning

confidence: 97%

Cytotoxicity of some Cameroonian spices and selected medicinal plant extracts

Kuete

Krusche

Youns

et al. 2011

Journal of Ethnopharmacology

170

106

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“…The plant contains a variety of chemical constituents, such as allantoin (Prista et al, 1960), kombic acid (Lok et al, 1983), isoflavones-7,4 -dimethoxy-2 hydroxylisoflavone and 2 -hydroxyformononetin (Omobuwajo et al, 1992), dihydroguaiacetic acid (Njoku et al, 1997), pycnanthuquinone A and B (Fort et al, 2000) and pycnanolide A and B (Onocha and Ali, 2011).…”

Section: Introductionmentioning

confidence: 99%

Antinociceptive and antiulcer activities of Pycnanthus angolensis

Sofidiya

Awolesi

2015

Revista Brasileira de Farmacognosia

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a b s t r a c tPycnanthus angolensis (Welw) Warb., Myristicaceae, is used in Nigeria folk medicine to treat complaints such as toothache, headache, sore throat, ulcers and wounds. The aim of the study was to investigate the antinociceptive and antiulcer activities of the stem bark extract of Pycnanthus angolensis. Acute toxicity was conducted with a single oral dose of 5 g/kg. Antinociceptive activity was evaluated in acetic acid-induced writhing, formalin and tail immersion tests in mice while antiulcer activity was evaluated in ethanol and indomethacin-induced models in rats. In acetic acid-induced writhing test, the extract (50, 100 and 150 mg/kg, p.o.), significantly reduced the number of writhes (46.75%, 57.28% and 75.69%) respectively, compared to control. The extract significantly (p < 0.001) reduced the time spent in licking the hind paw at both phases, in formalin test. In tail immersion test, significant antinociceptive effect was only observed with the dose of 150 mg/kg, with peak effect at 90 min (43.38%). There is no significant change in the spontaneous locomotor activity of animals in the open field. The extract prevented the gastric ulceration caused by ethanol and indomethacin treatments compared to control. The results showed that P. angolensis extract possesses antinociceptive and antiulcer activities supporting the traditional use for relieving pain and ulcers.

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Kombic acid, a hydroquinone polyisoprenoic carboxylic acid from Pycnanthus kombo seed fat

Cited by 14 publications

References 3 publications

Novel Antihyperglycemic Terpenoid-Quinones from Pycnanthus angolensis

Novel Antihyperglycemic Terpenoid-Quinones from Pycnanthus angolensis

Cytotoxicity of some Cameroonian spices and selected medicinal plant extracts

Antinociceptive and antiulcer activities of Pycnanthus angolensis

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