What makes innovation processes in industry succeed? The basic assumption of this paper is that not only technological, but also social—especially work-related—factors have a decisive impact. While processes of sociotechnical system design are established interdisciplinarily and have arrived at least in many large companies, to the best of our knowledge it still is a novelty in industrial contexts to also add the concept of sustainability to this perspective. Energy and circular economy as well as a shortage of skilled workers dominate the concerns of companies. At the same time, technologies such as artificial intelligence (AI) are traded as a beacon of hope to strengthen competitiveness and contribute to more efficient, resource-conserving economic activity (e.g., Lukic et al., BCG 10.01.2023, 2023).). With the design of AI-supported work systems in the textile and related industries, the WIRKsam Competence Center for Work Research wants to show how the use of artificial intelligence, with appropriate work design, can promote both innovative, human-centered work and economic competitiveness, so that the two benefit from each other. The project aims to strengthen the industrial backbone of the Rhenish mining area and to create attractive conditions and opportunities for skilled workers. In this way, a sustainable result of the various transformation levels in the area of structural change, digitalization and the future of work can be achieved, which lays the foundation for shaping further future transformation processes in an innovative way. In this paper, we develop central questions originating from this claim that need to be considered in the aforementioned transformation processes in the areas of people, technology and organization, because they can be decisive for success.