Komplikasi Jangka Pendek dan Jangka Panjang Diabetes Mellitus Tipe 1

Himawan, Indra; Pulungan, Aman B; Tridjaja, Bambang; Batubara, Jose Rl

doi:10.14238/sp10.6.2009.367-72

Cited by 11 publications

(13 citation statements)

References 6 publications

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“…21 Himawan et al also reported a DKA prevalence to be 43.6% in female patients (17 patient) and 33.3% in male patients (13 patient), presented in early diagnosis of DKA, the prevalence was 86.7% in 26 patients and many of them were female. 5 Alphonsus and Emeka reported from 37 patients, the males:females ratio was 1:1.5. 18 Factors that precipitate DKA in children and adolescents include emotional stress, infection, missed insulin injection, trauma, pancreatitis, and poor compliance to medication in patients with known diabetes.…”

Section: Discussionmentioning

confidence: 91%

“…4 Himawan et al reported a DKA prevalence of 43.6% in girls. 5 The long-term effects of diabetes mellitus include retinopathy, chronic kidney disease (nephropathy), neuropathy, and dyslipidemia. 2 In Indonesia, DKA is often unidentified and therapy inadequate, due to several factors such as a dearth of health care facilities in remote areas, a culture of avoiding doctors, financial constraints, and regulations governing access to care.…”

mentioning

confidence: 99%

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Diabetic ketoacidosis with acute kidney injury in prepubertal children: a report on two cases

Andriyani¹,

Wahyudhi²,

Anggriawan³

2017

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Type 1 diabetes mellitus is a result of autoimmune damage, in which environmental factors are thought to trigger the autoimmune destruction of pancreatic ß-cells.1,2 Worldwide, an estimated 65,000 children under 15 years of age develop type 1 diabetes mellitus each year.3 Approximately 30% of children who present with newly-diagnosed type 1 diabetes have diabetic ketoacidosis (DKA).4 Himawan et al. reported a DKA prevalence of43.6% in girls.5 The long-term effects of diabetes mellitus include retinopathy, chronic kidney disease (nephropathy), neuropathy, and dyslipidemia.2

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Section: Discussionmentioning

confidence: 91%

mentioning

confidence: 99%

Diabetic ketoacidosis with acute kidney injury in prepubertal children: a report on two cases

Andriyani¹,

Wahyudhi²,

Anggriawan³

2017

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“…Berdasarkan data ISPAD pada tahun yang sama menyebutkan bahwa perbedaan jenis kelamin terhadap Locus HLA-DR dan HLA-DQ di regio kelas II dianggap insiden DM tipe 1 tidak terjadi secara keseluruhan di mempunyai risiko terhadap terjadinya DM tipe 1 (25). seluruh dunia (5). Adanya perbedaan ini disebabkan oleh Selain itu, pengaruh genetik tertentu dan pengaruh perbedaan populasi, ras, dan jumlah subjek penelitian lingkungan yang berbeda dapat mempengaruhi kadar (13,14).…”

Section: Endokrinologi Anak Pengurus Pusat Ikatan Dokterunclassified

Korelasi antara kadar Osteocalcin, HbA1C dan 25(OH)D3 pada Anak dengan Diabetes Melitus Tipe 1

Wulandari

2018

JKB

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Masalah yang terjadi di banyak negara salah satunya adalah Diabetes Melitus tipe 1. Prevalensi DM tipe 1 di Indonesia masih belum jelas. DM tipe 1 disebabkan berkurangnya sekresi insulin akibat kerusakan fungsi sel β pankreas oleh karena respon autoimun. Diabetik osteopati merupakan salah satu komplikasi DM, yaitu peningkatan terjadinya osteoporosis. Penelitian ini bertujuan mencari korelasi antara kadar 25(OH)D3, kontrol glikemik dengan mengukur kadar HbA1c dan osteocalcin , sebagai penanda biokimia struktur tulang. Dua puluh enam anak dengan DM tipe 1 adalah sebagai subjek penelitian. Data dianalisis secara statistik dengan menggunakan Shapiro Wilk, korelasi Pearson dan Spearman. Karakteristik sampel menunjukkan jenis kelamin didominasi perempuan 58% dan didominasi dengan gizi baik (73%). Status vitamin D didominasi defisiensi (61,5%). Kadar HbA1C <7,5 % sebanyak 27%. Rerata usia pasien adalah 12,31 ± 3,069 tahun, dosis insulin 1,17±0,233 IU, kadar GDP 115,08±46,742 mg/dL, dan kadar GDS 144,65±76,365 mg/dL. Tidak didapatkan korelasi yang signifikan antara kadar HbA1c (p=0,472, r=-0,148) dan osteocalcin (p=0,407, r=0,17) dengan kadar 25(OH)D3. Demikian juga antara osteocalcin dan kadar HbA1c. Kesimpulan tidak diapatkan korelasi antara kadar osteocalcin , kadar HbA1c, dan kadar 25(OH)D3.

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“…Insulin dose adjustment aims to achieve optimal metabolic control, without increasing the risk of hypoglycemia and without neglecting the quality of life of patients both short and long term. During the 'honeymoon' period the total daily dose of insulin is < 0.5 IU/kgBW/day, the child before puberty (outside the 'honeymoon' period) in the dose range of 0.7-1.0 IU/kgBW/day, while during puberty the need increases above 1 IU to 2 IU/kgBW/day [23,24]. This may be the case in this study, with mean age of 12.46 ± 2.99 years for the K1 group and 12.15 ± 3.26 years for the K2 group which is the age of puberty, so that an average insulin dose of 11.14 ± 0.16 and 1.19 ± 0.29 IU/kgBW/ day for each group in order.…”

Section: Subject Characteristicsmentioning

confidence: 99%

Levels of 25(OH)D3, IL-2, and C-peptide in Children with Type 1 Diabetes Mellitus (T1DM) Receiving Vitamin D3 Supplementation

Suryanto

Tjahjono

Widjajanto

2018

J.Trop.Life.Science

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Type 1 Diabetes Mellitus (T1DM) has become a health problem in many countries. T1DM is the consequence of autoimmune destruction process of β cells. There was relationship between vitamin D deficiency with T1DM. The destruction process was caused by an imbalance of pro-inflammatory and anti-inflammatory cytokines. One of the pro-inflammatory cytokines is IL-2. C-peptide examination to see the function of beta cells due to destruction of pancreatic beta cell. Administration of vitamin D 3 supplementation still cause controversy and give varying results. This randomized clinical trial was conducted to determine the levels of 25(OH)D 3 , IL-2, and C-peptide in people with T1DM who received vitamin D 3 supplementation. The subjects were 26 children with T1DM, divided into K1 group (received vitamin D 3 supplementation) and K2 group (received placebo). The results showed higher levels of 25(OH)D 3 in the K1 group and statistically found a significant difference (p = 0.00). Higher levels of IL-2 and lower C-peptide were obtained in the K1 group and no statistically significant differences were found (p = 0.76 and p= 0.26). The insignificant relationship and the negative correlation were found between 25(OH)D 3 and IL-2 (p = 0.71; r = -0.12), 25(OH)D 3 and C-peptide (p = 0.59; r = -0.16), also levels of IL-2 and C-peptide (p = 0.13; r = -0.44) in children with type 1 diabetes who received vitamin D3 supplementation. From this study can be concluded that administration vitamin D 3 supplementation in patients with T1DM can increase levels 25(OH)D 3 significantly. This increase has not significantly lowered levels of IL-2 and increased levels of C-peptide. However, there was an absolute decrease in the rate of slower C-peptide in the supplemented group than in the placebo group.

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Komplikasi Jangka Pendek dan Jangka Panjang Diabetes Mellitus Tipe 1

Cited by 11 publications

References 6 publications

Diabetic ketoacidosis with acute kidney injury in prepubertal children: a report on two cases

Diabetic ketoacidosis with acute kidney injury in prepubertal children: a report on two cases

Korelasi antara kadar Osteocalcin, HbA1C dan 25(OH)D3 pada Anak dengan Diabetes Melitus Tipe 1

Levels of 25(OH)D3, IL-2, and C-peptide in Children with Type 1 Diabetes Mellitus (T1DM) Receiving Vitamin D3 Supplementation

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