Konjac Supplement Alleviated Hypercholesterolemia and Hyperglycemia in Type 2 Diabetic Subjects—A Randomized Double-Blind Trial

Chen, Hsiao‐Ling; Sheu, Wayne Huey‐Herng; Tai, Tsai-Sung; Liaw, Yung‐Po; Chen, Yi-Chuan

doi:10.1080/07315724.2003.10719273

Cited by 159 publications

(108 citation statements)

References 23 publications

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“…However, it has also been shown that the inhibition of the intestinal absorption is partially compensated for by an increase in hepatic cholesterol synthesis rate (Gylling et al, 1999;Jones et al, 2000). Glucomannan, on the other hand, suppresses the postprandial insulin peak by delaying the absorption of nutrients across the small intestine (Doi, 1995), as well as enhancing fecal excretion of neutral sterol and bile acids (Matsuura, 1986;Chen et al, 2003). The reduced postprandial insulin concentrations decrease cholesterol biosynthesis (Jones et al, 1993).…”

Section: Discussionmentioning

confidence: 99%

“…The optimal dosage of plant sterols has been reported to be 1.8 g/day (Katan et al, 2003), therefore this was the dose administered in the current study. On the other hand, owing to the limited number of studies involving glucomannan, the optimal dose of glucomannan has yet to be established and the range of reported glucomannan dose with significant cholesterol-lowering effect and minor side effects was between 3.6 and 13.0 g/day (Arvill and Bodin, 1995;Vuksan et al, 2000;Chen et al, 2003). Therefore, to avoid underestimating the therapeutic dose level of glucommanan, a relatively large 10 g/day dose was administered, as reported in a previous study showing efficacy of glucomannan (Vuksan et al, 2000).…”

Section: Experimental Design and Protocolmentioning

confidence: 99%

“…A soluble fiber, glucomannan has been acknowledged as being both a cholesterol-lowering (Doi et al, 1979;Arvill and Bodin, 1995;Vuksan et al, 2000;Chen et al, 2003) and hypoglycemic agent (Doi et al, 1990;Huang et al, 1990;Vuksan et al, 2000). It is hypothesized that glucomannan lowers cholesterol concentrations by decreasing the cholesterol biosynthesis rate.…”

Section: Introductionmentioning

confidence: 99%

“…The reduction of postprandial insulin concentration which occurs, suppresses hepatic cholesterol synthesis (Jones et al, 1993) possibly through a reduction in insulin-induced 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity (Lakshmanan et al, 1973). In addition, glucomannan increases fecal weight (Doi et al, 1990) and fecal bile acid excretion (Matsuura, 1986;Chen et al, 2003), and reduces serum bile acid concentration (Matsuura, 1986). The reduction in serum bile acid and increased fecal bile acid excretion are considered to be a part of the cholesterollowering mechanism as well.…”

Section: Introductionmentioning

confidence: 99%

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Effect of plant sterols and glucomannan on lipids in individuals with and without type II diabetes

et al. 2006

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Objective: The purpose of this study was to determine whether supplements of plant sterols and/or glucomannan improve lipid profile and cholesterol biosynthesis in mildly hypercholesterolemic type II diabetic and non-diabetic subjects and to compare the response of these two subject groups to the treatments. Design: A randomized, crossover study consisting of four phases of 21 days, with each phase separated by a 28-day washout. Setting: The Mary Emily Clinical Nutrition Research Unit of McGill University. Subjects: Eighteen non-diabetic individuals and 16 type II diabetic individuals aged 38-74 years. Interventions: Subjects were supplemented with plant sterols (1.8 g/day), glucomannan (10 g/day), a combination of glucomannan and plant sterols, and a placebo, provided in the form of bars. Results: Overall plasma cholesterol concentrations were lowered (Po0.05) after combination treatment (4.7270.20 mmol/l) compared to control (5.4770.18 mmol/l). Plasma low-density lipoprotein (LDL) cholesterol concentrations were decreased (Po0.05) after glucomannan (3.1670.14 mmol/l) and combination treatments (2.9570.16 mmol/l) compared to control (3.6070.16 mmol/l). The results of lipid profiles did not differ between subject groups. Overall plasma lathosterol concentrations, an index of cholesterol biosynthesis, were lowered (Po0.05) after the combination treatment compared to the plant sterol treatment. Conclusions:The results suggest that glucomannan and a combination of glucomannan and plant sterols substantially improves plasma LDL cholesterol concentrations.

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Section: Discussionmentioning

confidence: 99%

Section: Experimental Design and Protocolmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of plant sterols and glucomannan on lipids in individuals with and without type II diabetes

et al. 2006

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“…More over glucomannan (Konjac glucomannan) diet also resulted in improved lipid level and a decreased of diabet type2 fasting blood sugar . Based on this Konjac glucomannan can be used as a suitable supplement for type 2 diabetes [4]. In addition to improving blood lipid profile, glocomanan can also improve glycemic control and cystole blood pressure [13].…”

Section: Introductionmentioning

confidence: 99%

Effect of Dietary Amorphophallus sp From East Java on LDL-C Rats (Rattus novergicus Wistar Strain)

Harijati¹,

Widyarti²,

Azrianingsih³

2012

JTLS

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One of indication of obesity is high LDL-C . Obesity has serious risk to health, it can cause heart disease and stroke. Effort to lower obesity using drugs have significant side effects such as insomnia, increased blood pressure, dry mouth and so forth. Therefore using natural products that contain glucomannan to reduce obesity and LDL-C is good choise. Glucomannan in the global market derived from Amorphophallus konjac. In this study, we used glucomannan from Amorphophallus endemic East Java to reduce fattened Wistar rats. Amorphophallus that used include Amorphophallus muelleri, A.variabilis (variant: Brongkos 32; Brongkos 5; Wonorejo, Brangsi) and Amorphophallus campanulatus (Var Selopuro). Amorphophallus diet was given to white rats of Wistar strain that previously fattened using a mixture of cholesterol and lard, in addition to PARS (Chicken Feed Race Super) as a basic food. Amorphophallus konjac was used as control. Measurement of LDL-C was conducted in four different time points, namely 1). Prior to dietary cholesterol, 2). 24 days after the dietary cholesterol, 3) 11 days after Amorphophallus (+cholesterol) diet, 4). 25 days after Amorphophallus (+cholesterol) diet. The results showed that the diet of A.variabilis potentially lowered blood cholesterol levels for their respective 22.98%, 5.85% and 7.37% for consecutive variant Brongkos 32; Brongkos 5; Wonorejo. Diet from A.campanulatus and A.konjac had not been able to reduce cholesterol to the end of observation (25 days).

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Amorphophallus: Technological Interventions

Ray

Behera

2016

Tropical Roots and Tubers

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Konjac Supplement Alleviated Hypercholesterolemia and Hyperglycemia in Type 2 Diabetic Subjects—A Randomized Double-Blind Trial

Abstract: The KGM supplement improved blood lipid levels by enhancing fecal excretion of neutral sterol and bile acid and alleviated the elevated glucose levels in diabetic subjects. KGM could be an adjunct for the treatment of hyperlipidemic diabetic subjects.

Cited by 159 publications

References 23 publications

Effect of plant sterols and glucomannan on lipids in individuals with and without type II diabetes

Effect of plant sterols and glucomannan on lipids in individuals with and without type II diabetes

Effect of Dietary Amorphophallus sp From East Java on LDL-C Rats (Rattus novergicus Wistar Strain)

Amorphophallus: Technological Interventions

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