This special issue reveals pertinent academic discourses of 13 articles that had been presented in the 6th Regional Seminar on Higher Islamic Education (SeIPTI 2019), At Sultan Sharif Ali University, Brunei Darussalam. All articles connote within the themes of The Directions and Challenges of Regional Islamic Higher Education Institutions within the Modernization and Fourth Industrial Revolution. The articles presented and discussed in various angles of multi-discipline knowledge hence arrive at the same objectives to produce balance human being in accordance with Maqasid Syariah.