Konventionelle vs. pathogeninaktivierte Thrombozytenkonzentrate bei perioperativer Koagulopathie

Weber, Christian Friedrich; Meininger, Dirk; Byhahn, Christian; Seifried, Erhard; Zacharowski, Kai; Ádám, Emma; Henschler, Reinhard; Müller, Michael

doi:10.1007/s00104-010-2023-2

Cited by 4 publications

(1 citation statement)

References 27 publications

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“…However, the latter did not observe any functional improvement of the thrombocytes. Other studies observed lower mortality and a reduced haemorrhage volume in patients who received PC following APA therapy ( 164 ) and a lower platelet increment when pathogen-inactivated PC was used for transfusion ( 165 ). Only in one RCT, a novel pharmacological approach (PB2452) was successfully examined, which directly improved platelet function despite previous APA intake ( 166 ).…”

Section: Resultsmentioning

confidence: 95%

Coagulopathy management of multiple injured patients – a comprehensive literature review of the European guideline 2019

et al. 2022

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The European guideline on the management of trauma-induced major bleeding and coagulopathy summarises the most relevant recommendations for trauma coagulopathy management. The management of trauma-induced major bleeding should interdisciplinary follow algorithms which distinguish between life-threatening and non-life-threatening bleeding. Point-of-care viscoelastic methods (VEM) assist target-controlled haemostatic treatment. Neither conventional coagulation assays nor VEM should delay treatment in life-threatening trauma-induced bleeding. Adjustments may be rational due to local circumstances, including the availability of blood products, pharmaceuticals, and employees.

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Section: Resultsmentioning

confidence: 95%

Coagulopathy management of multiple injured patients – a comprehensive literature review of the European guideline 2019

et al. 2022

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Management of Hemorrhage in Cardiothoracic Surgery

Görlinger

Shore‐Lesserson

Dirkmann

et al. 2013

Journal of Cardiothoracic and Vascular Anesthesia

140

103

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The platelets’ perspective to pathogen reduction technologies

2017

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A wide variety of clinical conditions, associated with low circulating platelet counts, require platelet transfusion in order to normalize hemostatic function. Although single-donor apheresis platelets bear the lowest risk of transfusion-transmitted infections, pathogen reduction technologies (PRT) are being implemented worldwide to reduce this risk further through inactivation of known, emergent and as yet to be discovered nucleic acid-based pathogens. Human blood platelets are now known to harbor a diverse transcriptome, important to their function and comprised of >5000 protein-coding messenger RNAs and different classes of non-coding RNAs, including microRNAs. Our appreciation of the nucleic acid-dependent functions of platelets is likely to increase. On the other hand, the side effects of PRT on platelet function are underappreciated. Recent evidences suggest that PRT may compromise platelets' responsiveness to agonists, and induce platelet activation. For instance, platelets have the propensity to release proinflammatory microparticles (MPs) upon activation, and the possibility that PRT may enhance the production of platelet MPs in platelet concentrates (PCs) appears likely. With this in mind, it would be timely and appropriate to investigate other means to inactivate pathogens more specifically, or to modify the currently available PRT so to better preserve the platelet function and improve the safety of PCs; platelets' perspective to PRT deserves to be considered.

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Konventionelle vs. pathogeninaktivierte Thrombozytenkonzentrate bei perioperativer Koagulopathie

Abstract: Whereas ex-vivo analyses of platelet function did not show any group differences at T1, a significantly lower increment was seen in the pilot study after transfusion of PI-PC as compared to conventional PC.

Cited by 4 publications

References 27 publications

Coagulopathy management of multiple injured patients – a comprehensive literature review of the European guideline 2019

Coagulopathy management of multiple injured patients – a comprehensive literature review of the European guideline 2019

Management of Hemorrhage in Cardiothoracic Surgery

The platelets’ perspective to pathogen reduction technologies

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