Konya ilinde büllöz hastalıklar: 93 olgu üzerine bir çalışma

Daye, Munise; Mevlitoğlu, İnci; Esener, Sarenur

doi:10.4274/turkderm.04810

Cited by 3 publications

(6 citation statements)

References 13 publications

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“…Furthermore, the PV/BP ratio in our study was 0.96, and this ratio was reported to be between 1.1-1.5 in previous reports from Turkey. Although the demographic and clinical characteristics of ABD patients were in accordance with previous studies, most of the DH patients in our study were female (3,6,7,10,13). It is known that DH affects males more frequently, but the predominance of female patients was also reported if there was an accompanying autoimmune disease, as in our study (10,13).…”

Section: Discussionsupporting

confidence: 86%

“…In the literature, BP was reported as the most frequent ABD in developed countries, but in our country, it was the second most common ABD after PV. A significant increase in the number of patients has also been noted in recent years, probably due to prolongation of the lifespan (3,6,7). Furthermore, the PV/BP ratio in our study was 0.96, and this ratio was reported to be between 1.1-1.5 in previous reports from Turkey.…”

Section: Discussionsupporting

confidence: 70%

“…In the first reports, when only systemic drugs were investigated, physical factors (such as local trauma, ultraviolet rays, and radiotherapy), infections, and vaccinations also began to be reported (9). The most identified drugs were diuretics, angiotensin-converting enzyme inhibitors, acetylsalicylic acid, and benzodiazepines (7,9,18,19). Although it was at a low percentage when compared to the study conducted by Daye et al, in our study, a relationship between the use of drugs and disease onset was determined in 24% of BP patients, and triggering drug use was determined in 44% of BP patients (7).…”

Section: Discussionmentioning

confidence: 99%

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Possible triggering factors and comorbidities in newlydiagnosed autoimmune bullous diseases

Akarsu¹,

Özbağçıvan²,

Dolaş³

et al. 2017

Turk J Med Sci

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IntroductionAutoimmune bullous diseases (ABDs) are a group of rarely seen organ-specific diseases caused by pathogenic autoantibodies against target antigens that function in the intercellular or the mesenchymal/dermal junction of the epidermis. Clinically, ABDs display quite a wide spectrum of vesicle or bulla formations on the skin and/or the mucous membranes. ABDs are classified mainly as intraepidermal bullous disease (pemphigus) and subepidermal bullous diseases (pemphigoid, dermatitis herpetiformis, and acquired epidermolysis bullosa), according to the depth of blister formation on the skin and types of autoantibodies against structural proteins (1). Generally, pemphigus vulgaris (PV) and bullous pemphigoid (BP) form the greater portion of ABDs, and therefore they are the most frequently known ABDs (1,2).The demographic, clinical, and etiological characteristics of ABDs and the incidence of subgroups vary according to geographic regions (1,2). In Turkey, despite the absence of national data, the first annual incidence estimations in the Mediterranean and Aegean regions of the country were reported as 2.4 and 1.8 per million by Uzun et al. and Bozdag and Bilgin, respectively (3,4). However, it was observed that these limited numbers of published data were of retrospective nature and focused on pemphigus only (3-5). Nevertheless, one of the two recently published retrospective studies from Turkey covered pemphigus with other ABDs, and the other included patients with hereditary bullous diseases and other ABDs (6,7). In this study we aimed to evaluate demographic data, clinical characteristics, related triggering factors, and comorbidities of newly diagnosed patients with ABDs at our clinic.Background/aim: The distribution and the demographic, etiological, and clinical features of autoimmune bullous diseases (ABDs) vary according to geographic regions of the world. The limited number of reported studies in Turkey are mostly retrospective and generally include only pemphigus. The aim of our study was to evaluate the demographic data, clinical features, associated triggering factors, and comorbidities in patients newly diagnosed with ABDs. Materials and methods:In this descriptive and prospective study, the demographic data, inhabited regions, smoking and drinking habits, presence of comorbidities, and specific and general potential triggering factors of ABDs considered by the patients were examined. Furthermore, the distribution of lesions and autoimmune bullous skin disorder intensity scores were recorded.Results: Of the total 59 ABD patients, 26 (44.1%) were diagnosed with pemphigus, 25 (42.4%) were diagnosed with pemphigoid, and 8 (13.5%) were diagnosed with dermatitis herpetiformis. Although there were some differences between the subgroups of ABDs, the onset of the disease was associated with a triggering factor (stress, foods, physical trauma, chemical agents, ultraviolet rays, medications, infections, malignancies, and pregnancy, in a decreasing frequency) in 96.6% of the patients. Autoimmune diseases, ...

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Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Possible triggering factors and comorbidities in newlydiagnosed autoimmune bullous diseases

Akarsu¹,

Özbağçıvan²,

Dolaş³

et al. 2017

Turk J Med Sci

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show abstract

“…[5][6][7] In studies conducted in Turkey, in support of the literature, PV has been reported as the most frequently seen ABD, followed by BP. [1,[7][8][9] Similarly, in our study, the frequency was 51.4% for PV and 41.5% for BP.…”

Section: Discussionsupporting

confidence: 64%

Comorbidity profiles among patients with autoimmune bullous diseases; a retrospective study

2018

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Objectives: The purpose of the present study was to define the accompanying diseases of patients with autoimmune bullous diseases (ABDs). Methods: One hundred forty-two patients with ABD who were followed up in the dermatology and venereology inpatient clinic of Şişli Hamidiye Etfal Training and Research Hospital between January 1999 and December 2015 were enrolled in the study. Age, gender, and accompanying diseases of the participants were recorded and compared with the healthy subjects. Results: Eighty patients with pemphigus, 62 patients with pemphigoid, and 217 healthy subjects were included in the study. The pemphigoid group had a statistically significant higher prevalence of hypertension, diabetes mellitus, coronary artery diseases, cataract, malignancy, dementia, Alzheimer’s disease, Parkinson’s disease, and cerebrovascular events relative to the pemphigus and control groups (p<0.01, p<0.01, p=0.001, p<0.01, p=0.02, p=0.008, p=0.001, p=0.001, and p<0.01, respectively). The prevalence of asthma, benign prostatic hyperplasia, and cataract was higher in the pemphigus group than in the controls (p=0.02, p=0.04, and p=0.02, respectively). Conclusion: To the best of our knowledge, this is the first study comparing accompanying diseases between controls and patients with pemphigus and pemphigoid. It is disputable whether the diseases mentioned occur due to some common pathophysiological pathways or coexist just coincidentally. We believe that it is important to evaluate accompanying diseases in patients with ABD.

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“…İngiltere'de yapılan 869 olguluk retrospektif çalışmada hastalığın başlangıç yaşı median 80 olarak bildirilmiştir 13 . Ülkemizde yapılan diğer çalışmalarda (Tablo 2) [14][15][16][17] olduğu gibi olgularımızın yaş ortalaması 60 üzerindeydi. Olgularımızın tanı anındaki yaşı ortalama 69,54 olarak saptanırken en genç olgu 18 yaşında idi.…”

Section: Discussionunclassified

Retrospective analysis of the forty-six patients with bullous pemphigoid followed-up in our clinic

Yazıcı¹,

Başkan²,

Tunali³

et al. 2016

TURKDERM

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Background and Design: Bullous pemphigoid (BP) is an autoimmune disease characterised by widespread itchy plaques and subepithelial blisterings and usually affects the elderly population. Due to the chronic nature of the disease, to prevent the side effects of chronic steroid treatment, adjuvant immunosuppressive (mycophenolate mofetil, azathioprine, methotrexate) and anti-inflammatory (tetracycline, nicotinamide, dapsone) agents may be used. In this study, we retrospectively evaluated the clinical and demographic characteristics and applied treatments of 46 patients with the diagnosis of BP and compared with literature data. Materials and Methods: We retrospectively evaluated the records of 46 patients who received clinical and histopathological diagnosis of BP and followed up in our clinic between 2006 and 2013. Results: Of the 46 patients, 22 were female and 24 male. The mean age of onset was 69.54 years (range: 18-105). The duration of the lesion ranged from 1 week to 10 months with a median duration of 8 weeks. The most frequent comorbid chronic disease was hypertension detected in 28 (60.8%) patients. Only four patients had a history of malignancy before the onset of the disease. Nineteen patients (42%) used more than 5 agents for comorbid diseases. Thirty-two patients (69.5%) used systemic corticosteroids alone and ten (22%) patients needed additional adjuvant therapies. Conclusion: BP is a major cause of morbidity in the elderly population receiving multiple drug treatment. To avoid the side effects of steroid therapy, especially in patients with severe disease, short-term use of additional immunosuppressive agents appears to be safe and effective.

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Konya ilinde büllöz hastalıklar: 93 olgu üzerine bir çalışma

Cited by 3 publications

References 13 publications

Possible triggering factors and comorbidities in newlydiagnosed autoimmune bullous diseases

Possible triggering factors and comorbidities in newlydiagnosed autoimmune bullous diseases

Comorbidity profiles among patients with autoimmune bullous diseases; a retrospective study

Retrospective analysis of the forty-six patients with bullous pemphigoid followed-up in our clinic

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