This paper addresses the image-based visual servoing (IBVS) control problem with an uncalibrated camera, unknown dynamics, and constraints. A novel data-driven uncalibrated IBVS (UIBVS) strategy is proposed, incorporated with the Koopman-based model predictive control (KMPC) algorithm and the adaptive robust Kalman filter (ARKF). First, to alleviate the need for calibration of the camera’s intrinsic and extrinsic parameters, the ARKF with an adaptive factor is utilized to estimate the image Jacobian matrix online, thereby eliminating the laborious camera calibration procedures and improving robustness against camera disturbances. Then, a data-driven MPC strategy is proposed, wherein the unknown nonlinear dynamic model is learned using the Koopman operator theory, resulting in a linear Koopman prediction model. Only input–output data are used to construct the prediction model, and hence, the proposed approach is robust against model uncertainties. Furthermore, with a symmetric quadratic cost function, the proposed approach solves the quadratic programming problem online, and visibility constraints as well as joint torque constraints are taken into account. As a result, the proposed KMPC scheme can be implemented in real time, and the UIBVS performance degradation which arises from the control torque constraints can be avoided. Simulations and comparisons for a 2-DOF robotic manipulator demonstrate the feasibility of the proposed approach. Simulation results further validate that the computation time of the proposed approach is comparable to the one of kinematic-based methods.