Kopfgruppeneinflu� homologer 1,2-Dihexadecylglycerophospholipide auf die Phasenumwandlungen ihrer Phospholipid/Wasser-Mischungen im heterogenen Zweiphasengebiet

Dörfler, H.‐D.; Brezesinski, Gerald; Nuhn, P.; Rüger, Hans-Jürgen; Kertscher, P.

doi:10.1007/bf01421890

Cited by 5 publications

References 15 publications

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Miscibility behavior of ternary lipidphospholipid/water systems

Dörfler

Pietschmann

1990

Colloid & Polymer Sci

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Differential-scanning-calorimetry was applied to study the lyotropic and thermotropic properties of the two ternary systems dimyristoylcephaline (di-(C14:0)-PE)/Palmitic acid (C15COOH)/water (H20) and dimyristoylcephaline (di-(C14:0)-PE)/palrnitic acid methyl ester (C15COOMe)/water (H20) in dispersions with excess water (50 wt.%). The phase diagrams of both systems showed that the two systems differ in their miscibility behavior. The system di-(C14:0)-PE/C15COOH/H20 is completely miscible in its high-temperature phase. In the low-temperature phase the mixing gap was found within the concentration range of C15COOH and was also indicated by a maximum value of the transition enthalpy of the pseudo-binary mixtures. In the pseudo-binary system di-(C14:0)-PC/C15COOMe/H20, the tendency towards dernixing is much more pronounced. It was observed that the incorporated C15COOMe melted above its normal melting point, but below the transition temperature of di-(C14:0)-PE/H20 system; therefore, the phase transition started at lower temperature. In the low-temperature phase, both lipids are partially miscible. The demixing range of the phase diagram lies within the concentration region of C15COOMe. Up to the mole fraction of XClsCOOMe = 0.43, C15COOMe can be incorporated into the L~phase of the system di-(C14:0)-PE/H20.

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