Korean ginseng induces spermatogenesis in rats through the activation of cAMP-responsive element modulator (CREM)

Park, Wan Su; Shin, Dong Youp; Kim, Do Rim; Yang, Woong Mο; Chang, Mun Seog; Park, Seong Kyu

doi:10.1016/j.fertnstert.2006.12.014

Cited by 32 publications

(26 citation statements)

References 16 publications

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“…Later studies in both rodents and humans have shown that ginseng can increase sperm count. Ginseng-treated rats have demonstrated an increased rate of spermatogenesis via glial cell-derived neurotrophic factor (GDNF) expression elevation in Sertoli cells, 30 and activation of testicular cAMP-responsive element modulator (CREM) 31 . GDNF is a possible regulator of the survival and cell fate decision of undifferentiated spermatogonial cells, 32 , 33 and CREM is essential for spermatid maturation 34 .…”

Section: Sperm Production and Qualitymentioning

confidence: 99%

Ginseng and male reproductive function

Leung

Wong

2013

Spermatogenesis

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Ginseng is often referred to as the King of all herbs, and is found to be a promising agent to improve general well-being. Ginseng has also been reputed as an aphrodisiac, and is used to treat sexual dysfunction as well as to enhance sexual behavior in traditional Chinese medical practices. Data from animal studies have shown a positive correlation among ginseng, libido, and copulatory performances, and these effects have been confirmed in case-control studies in human. In addition, ginseng is found to improve the sperm quality and count of healthy individuals as well as patients with treatment-related infertility. These actions are mostly attributed to ginsenosides, the major pharmacological active components of ginseng. This review compiles the current knowledge about the multifaceted effects of ginseng on male reproductive function, and also focuses on its mechanisms of action that may represent novel therapeutic strategies for the treatment of male reproductive diseases or disorders.

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Section: Sperm Production and Qualitymentioning

confidence: 99%

Ginseng and male reproductive function

Leung

Wong

2013

Spermatogenesis

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“…P. ginseng aqueous extract also was shown to increase epididymal sperm count and sperm motility, expression of testicular cyclic adenosine monophosphate (cAMP)-responsive element modulator (CREM) messenger RNA (mRNA), and CREM protein in treated male rats [8].…”

Section: Panax Ginsengmentioning

confidence: 99%

Rise of Herbal and Traditional Medicine in Erectile Dysfunction Management

Tan

2011

Curr Urol Rep

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Herbal medicine long has been used in the management of sexual dysfunction, including erectile dysfunction. Many patients have attested to the efficacy of this treatment. However, is it evidence-based medicine? Studies have been done on animal models, mainly in the laboratory. However, randomized controlled trials on humans are scarce. The only herbal medications that have been studied for erectile dysfunction are Panax ginseng, Butea superba, Epimedium herbs (icariin), Tribulus terrestris, Securidaca longipedunculata, Piper guineense, and yohimbine. Of these, only Panax ginseng, B. superb, and yohimbine have published studies done on humans. Unfortunately, these published trials on humans were not robust. Many herbal therapies appear to have potential benefits, and similarly, the health risks of various phytotherapeutic compounds need to be elucidated. Properly designed human trials should be worked out and encouraged to determine the efficacy and safety of potential phytotherapies.

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“…人蔘은 『本草蒙筌』에서 "滋補元陽", 『本草再新』에서 "固精滋水"라 하여 남성불임 치료와 관련하여 언급되어 있으며 11) , 男性不育에 활용된 처방 으로 『東醫寶鑑』에서 固本健陽丹, 瓊玉膏, 延年益壽不老丹, 延齡固本丹, 固眞飮子 등 남성의 精을 보하는 효능에 人蔘이 사용되었다 12) . 본 연구팀은 인삼이 흰쥐에서 정자의 수를 증가시키는 것 이 CREM 유전자 발현을 향상시키는 기전과 관련되어 있음과 정자의 전체 운동성을 높여주는 것을 보고하였다 13) . …”

Section: 서 론unclassified

“…인삼은 원인불명의 정자결핍증 환자군과 특발성 정맥류를 가진 정자 결핍증 환자군 모두에서 정자 수 및 정자운동성의 현저한 증 가를 보였으며, 정상인에 대해서도 유의한 증가를 보였다 28) . 또한, 인삼을 투여한 흰쥐에서 정자의 수의 증가는 정자형성 에 관여하는 cAMP-responsive element modulator (CREM) 유전자의 발현이 증가하는 것과 관련이 있는 것으로 나타났다 13) . 그러나 정자의 운동성 중에서도 정자의 hyperactivation 운동성에 특이적으로 작용하는 CatSper 유전자에 미치는 인 삼의 효과는 보고되지 않았다.…”

Section: 인삼이 Catsper4 단백질 발현에 미치는 영향unclassified

Effects of Ginseng Radix on sperm count and CatSper3, 4 proteins expression in Male Mice

Park¹,

Kim²,

Park³

et al. 2012

The Korea Journal of Herbology

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Objectives：The purpose of this study was to investigate the reproductive effect of Ginseng radix on male mice. Methods：Male C57BL/6J mice were divided into four groups； normal group (vehicle-treated, n=8), Ginseng radix treatment group (100, 500, 1000 mg/kg, n=8). Ginseng radix extract was treated for 5 weeks. After treatment each group was examined for assessment of sperm count and CatSper protein expression using computer assisted semen analysis (CASA) system and the immunofluorescence. Results：Sperm count of normal and Ginseng radix extract treated group were 287.57 vs. 371.62, 364.83, 343.29 x10 6 , respectively. The CatSper3, 4 proteins expression of Ginseng radix treated group were significantly increased than that of normal group. Conclusions：These findings suggest that the Ginseng radix improves male reproductive function by increasing sperm count and CatSper protein expression.

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Korean ginseng induces spermatogenesis in rats through the activation of cAMP-responsive element modulator (CREM)

Cited by 32 publications

References 16 publications

Ginseng and male reproductive function

Ginseng and male reproductive function

Rise of Herbal and Traditional Medicine in Erectile Dysfunction Management

Effects of Ginseng Radix on sperm count and CatSper3, 4 proteins expression in Male Mice

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