Kounis syndrome secondary to amoxicillin use in an asthmatic patient

Acute coronary syndrome secondary to allergic coronary vasospasm (Kounis Syndrome): a case series, follow-up and literature review

“…Ruptured plaques, a traditional known reason for acute coronary syndrome, may not be the explanation for this case. It seems that atopic individuals are at higher risk of acute coronary syndromes than normal people [19]. A population based study revealed a causal role of IgE in the development of cardiovascular disease [20], mast cell degranulation inhibitors might prevent acute thrombotic events [21], this may explain why administration of clopidogrel helped to cease the episodes of ischemic chest pain in our cases.…”

Clinical features, diagnosis and management of amoxicillin-induced Kounis syndrome

“…Of the remaining 79 studies, 48 were excluded from the full-text review. A total of 31 studies were included ( Alemparte Pardavila et al, 1999 ; López-Abad et al, 2004 ; Moreno-Ancillo et al, 2004 ; Gikas et al, 2005 ; Del Furia et al, 2007 ; Tigen et al, 2007 ; Tavil et al, 2008 ; Vivas et al, 2008 ; Biteker et al, 2009 ; Caglar et al, 2011 ; Venturini et al, 2011 ; Viana-Tejedor et al, 2011 ; Mazarakis et al, 2012 ; Bezgin et al, 2013 ; Calf et al, 2013 ; Ilhan et al, 2013 ; Kilickesmez et al, 2013 ; Lombardi et al, 2013 ; González-de-Olano et al, 2014 ; Ralapanawa and Kularatne, 2015 ; Molina Anguita et al, 2016 ; Salouage et al, 2016 ; Shimi et al, 2016 ; Antonelli et al, 2017 ; Canpolat et al, 2017 ; Omri et al, 2017 ; Pradhan et al, 2018 ; Lopes and Agarwal, 2019 ; Moloney et al, 2019 ; Caragnano et al, 2020 ; Duarte et al, 2020 ). The basic information of these 33 patients is summarized in Table 1 .…”

“…Of the 27 recorded cases, 3 patients (11.1%) had elevated troponin T, 3 patients (11.1%) had normal troponin I, and 21 patients (77.8%) had elevated troponin I, with a median of 2.2 ng/ml (range 0.064–2046). Creatine kinase (CK) was reported in 15 patients(45.5%), with elevations in 10 patients (30.3%) ( Alemparte Pardavila et al, 1999 ; Moreno-Ancillo et al, 2004 ; Gikas et al, 2005 ; Tigen et al, 2007 ; Caglar et al, 2011 ; Viana-Tejedor et al, 2011 ; Bezgin et al, 2013 ; Antonelli et al, 2017 ; Pradhan et al, 2018 ; Duarte et al, 2020 ). Nine patients (27.3%) reported elevated creatine kinase-myocardial band (CK-MB) ( Moreno-Ancillo et al, 2004 ; Gikas et al, 2005 ; Tigen et al, 2007 ; Tavil et al, 2008 ; Biteker et al, 2009 ; Venturini et al, 2011 ; Bezgin et al, 2013 ; Kilickesmez et al, 2013 ; Omri et al, 2017 ).…”

Myocardial Infarction in the Setting of Anaphylaxis to Celecoxib: A Case of Kounis Syndrome

“…Individuals with atopy are at increased risk of developing Kounis syndrome compared to normal individuals, and often experience worse symptoms due to an amplified inflammatory response (10,11). Prognosis depends on several elements, including magnitude of the initial response, patient sensitivity, comorbidity, site of antibody-antigen reaction, allergen concentration, and the route of allergen entrance (12).…”