Krebs von den Lungen-6 associated with chest high-resolution CT score in evaluation severity of patients with interstitial lung disease

Qin, Hui; Xu, Xiaoqing; Zou, Jing; Zhao, Xiaojing; Wu, Huawei; Zha, Qianqian; Chen, Sheng; Kang, Yu; Jiang, Hui

doi:10.1016/j.pulmoe.2018.05.008

Cited by 24 publications

(23 citation statements)

References 17 publications

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“…In this work, there is a significant negative correlation between KL-6 level and oxygen saturation, PaO 2 , and FVC. This was consistent with a study by Qin et al that reported a decrease in O 2 saturation and lung functions in patients with elevated KL-6 levels [22].…”

Section: Discussionsupporting

confidence: 93%

“…Moreover, Qin et al's study also reported that KL-6 levels in ILD were significantly higher than pneumonia, other types of parenchymal diseases (P < 0.000), and healthy controls (P < 0.05) [22].…”

Section: Discussionmentioning

confidence: 91%

“…Qin et al found a cut-off estimation of KL6 312 U/ml, with affectability and specificity to diagnose ILD 84.7% and 85.3%, respectively [22].…”

Section: Discussionmentioning

confidence: 99%

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Serum Krebs von den Lungen (KL-6) level as a marker of exacerbation of interstitial lung diseases

et al. 2020

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Background Krebs von den Lungen (KL-6) is elevated in serum of interstitial lung disease (ILD) patients based on its leakage from the alveolar space into the blood; KL-6 is significantly higher in patients with acute exacerbation of ILDs (AE-ILD) compared with stable patients. This study aimed to determine the sensitivity and specificity of KL6 to detect AE-ILD. Results This is a prospective cross sectional observational study was carried out on 88 subjects at the Chest Department, Minia Cardiothoracic University Hospital, during the period from August 2018 to August 2019. This study was approved by the hospital research ethics board of Minia University and informed consent was obtained. History, examination, spirometry, ABGs, X-ray, HRCT, CBC, ESR, CRP, and KL6 levels were done to both stable and exacerbation groups of ILDs. The level of biomarkers is compared between both groups and control. Statistical analysis done by using IBM SPSS statistical package version 20 (χ2 test and independent sample t test, ANOVA test, bivariate Pearson correlation analysis, and ROC curve analysis). The study showed that there is a significant difference between stable and exacerbating groups regarding fever, signs of RHF, dyspnea scale, FVC, and PaO2. Conclusion KL-6 cutoff ≥ 187.5 U/ml could exhibit AE-ILDs with a sensitivity of 98% and a specificity of 97%. KL-6 is a more sensitive and specific marker to detect AE-ILD.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 91%

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Serum Krebs von den Lungen (KL-6) level as a marker of exacerbation of interstitial lung diseases

et al. 2020

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“…A study of 47 patients with rheumatoid arthritis-associated pulmonary disease by Kinoshita et al also reported a positive correlation between serum KL-6 levels and total CT scores (r = 0.83, P < 0.001) [38]. In addition, a study of 98 patients with ILD by Qin et al showed that serum KL-6 levels were significantly correlated with DL CO (r = -0.513, P < 0.001) and CT scores (r = 0.539, P = 0.000) [39]. These results support that serum KL-6 levels may correlate with the severity of ILDs.…”

Section: Plos Onementioning

confidence: 94%

Serum Krebs von den Lungen-6 level predicts disease progression in interstitial lung disease

Cho

et al. 2020

PLoS ONE

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Disease progression (DP) in interstitial lung disease (ILD) is variable and difficult to predict. In previous reports, serum Krebs von den Lungen-6 (KL-6) was suggested to be useful in diagnosing and predicting survival in ILD. The aim of our study was to investigate the usefulness of serum KL-6 as a predictor of DP in ILD. Clinical data of 199 patients with ILD (idiopathic pulmonary fibrosis: 22.8%) were prospectively collected and serum KL-6 levels were measured. DP was defined as a relative decline in forced vital capacity (FVC) ≥ 10%, acute exacerbation, or death during follow-up. The median follow-up period was 11.1 months. The mean age of the subjects was 62.2 years, and 59.8% were male. DP occurred in 21.6% of patients. The progressed group showed lower FVC, lower diffusing capacity for carbon monoxide, lower the minimum oxygen saturation during the 6-minute walk test, higher fibrosis scores on high-resolution computed tomography, and higher KL-6 levels (826.3 vs. 629.0 U/mL; p < 0.001) than those of the non-progressed group. In receiver operating characteristic curve analysis, serum KL-6 levels were a significant predictor of DP in ILD (area under the curve = 0.629, p = 0.009, and the optimal cut-off level was 811 U/mL). In multivariable Cox analysis, high serum KL-6 levels (≥ 800 U/mL) were only independently associated with DP in ILD (HR 2.689, 95% CI 1.445–5.004, P = 0.002). Serum KL-6 levels might be useful to predict DP in patients with ILD.

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“…The disease severity is highly variable according to the underlying condition but unfortunately, children with CLD have high overall morbidity and mortality [2]. Therefore, it is very important to find a non-invasive blood biomarker that could help in the diagnosis and predict the prognosis of ILD, it would be of more value in areas with limited resources to allow easier and earlier detection of more vulnerable patients [3].…”

Section: Introductionmentioning

confidence: 99%

Platelets count and platelets indices; mean platelet volume and plateletcrit in pediatric chronic lung disease

Draz

Shaheen

Youssef

2020

Egypt Pediatric Association Gaz

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Background: The lungs contribute in the final maturation of the circulating platelets, and some studies suggested that chronic lung disease (CLD) could impair circulating platelets maturation or count. Our aim was to study the validity of platelet count (PLT), mean platelet volume (MPV), and plateletcrit (PCT) as simple tools to assess chronic lung disease severity or predict its course. Results: In 39 pediatric patients with CLD, we showed a significant rise in PLTs and PCT and a significant lower MPV when compared to normal controls (P values 0.003, 0.010, 0.004, respectively). Also, a significant positive correlation was detected between the C reactive protein (CRP) level and both the PLTs and PCT (r 0.327, 0.363 respectively) in addition to a significant reduction in MPV level in relation to the age of disease onset (P value 0.031). Conclusion: This study disagrees with the postulation that chronic lung disease could lead to the reduction of circulating platelets and emphasizes the role of increased platelets count and decreased MPV in reflecting the inflammatory condition underlying the chronic lung disease in the pediatric age group.

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Krebs von den Lungen-6 associated with chest high-resolution CT score in evaluation severity of patients with interstitial lung disease

Abstract: Serum KL-6 might be useful in the diagnosis of ILD, especially in the hard-to-diagnose cases, with high sensitivity and specificity. Furthermore, KL-6 might be a valuable marker for evaluation of ILD severity.

Cited by 24 publications

References 17 publications

Serum Krebs von den Lungen (KL-6) level as a marker of exacerbation of interstitial lung diseases

Serum Krebs von den Lungen (KL-6) level as a marker of exacerbation of interstitial lung diseases

Serum Krebs von den Lungen-6 level predicts disease progression in interstitial lung disease

Platelets count and platelets indices; mean platelet volume and plateletcrit in pediatric chronic lung disease

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