2020
DOI: 10.1074/jbc.ra120.013114
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Krüppel-like factor 3 (KLF3) suppresses NF-κB–driven inflammation in mice

Abstract: Bacterial products such as lipopolysaccharides (or endotoxin) cause systemic inflammation, resulting in a substantial global health burden. The onset, progression, and resolution of the inflammatory response to endotoxin are usually tightly controlled to avoid chronic inflammation. Members of the NF-κB family of transcription factors are key drivers of inflammation that activate sets of genes in response to inflammatory signals. Such responses are typically short-lived and can be suppressed by proteins that ac… Show more

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Cited by 26 publications
(20 citation statements)
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“…This analysis predicted the expression networks of transcription factors that were upregulated in pro- or anti-inflammatory macrophages (Figure 3E). For instance, regulons driven by members of the IRF family were enriched in inflammatory macrophages, such as irf1 , which are essential in the development and activation of inflammatory macrophages ( 65 ), whereas KLF family members were enriched in non-inflammatory macrophages, such as klf3 , which play an important role in the inhibition of inflammation ( 66 ).…”
Section: Resultsmentioning
confidence: 99%
“…This analysis predicted the expression networks of transcription factors that were upregulated in pro- or anti-inflammatory macrophages (Figure 3E). For instance, regulons driven by members of the IRF family were enriched in inflammatory macrophages, such as irf1 , which are essential in the development and activation of inflammatory macrophages ( 65 ), whereas KLF family members were enriched in non-inflammatory macrophages, such as klf3 , which play an important role in the inhibition of inflammation ( 66 ).…”
Section: Resultsmentioning
confidence: 99%
“…While the mechanisms underlying had remained unclear, evidence of enhanced beiging in Klf3 −/− mice now provides a possible explanation. The role of haematopoietic cells in AT function and thermogenesis is now widely appreciated, and KLF3 is both active in haematopoietic lineages [29][30][31][32][33] and highly expressed in a range of haematopoietic cell types according to the Immgen 34 and Haemopedia 35,36 databases. We thus focused on a possible role for KLF3 in BM haematopoietic cells that could give rise to cells occupying the AT SVF niche and regulate adipose function.…”
Section: Resultsmentioning
confidence: 99%
“…BMDMs were cultured based on previously performed protocols (Knights et al , 2016; Knights et al , 2020b; Zhu et al , 2020). Briefly, femora and tibiae were extracted from 6 to 10 week old mice, flushed, and subjected to red blood cell lysis.…”
Section: Methodsmentioning
confidence: 99%