Kühnle, Steuerung und Controlling von Medienunternehmen

Kühnle, Boris Alexander

doi:10.15358/0935-0381-2008-8-9-431

Cited by 1 publication

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3.1.6. Acid Phosphatases-Only a few studies 257,348 have used acid phosphatases (ACP) for ENS after the early example of screening the inhibitors of ACPs based on hydrogelation resulted from ENS. 224 Borner et al used ACP to dephosphorylate polymerpeptide conjugates for self-assembly.…”

Section: Coupling With Other Controlling Mechanisms-mentioning

confidence: 99%

“…224 Borner et al used ACP to dephosphorylate polymerpeptide conjugates for self-assembly. 348 As shown in Figure 43, the polymer-peptide conjugates consist of five repeats of alternating threonine and valine diads ((TV) 5 ) at the Nterminal and a polyethylene glycol (PEO) block at the C-terminal. The (TV) 5 repeats favor the formation of β-sheets in water.…”

Section: Coupling With Other Controlling Mechanisms-mentioning

confidence: 99%

“…Microstructures formed by ACP triggered self-assembly of 74 visualized by TEM. Adapted from Ref 348. .…”

mentioning

confidence: 99%

See 2 more Smart Citations

Enzymatic Noncovalent Synthesis

et al. 2020

View full text Add to dashboard Cite

Enzymatic reactions and noncovalent (i.e., supramolecular) interactions are two fundamental nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process where enzymatic reactions control intermolecular noncovalent interactions for spatial organization of higher-order molecular assemblies that exhibit emergent properties and functions. Like enzymatic covalent synthesis (ECS), in which an enzyme catalyzes the formation of covalent bonds to generate individual molecules, ENS is a unifying theme for understanding the functions, morphologies, and locations of molecular ensembles in cellular environments. This review intends to provide a summary of the works of ENS within the last decade and emphasize ENS for functions. After comparing ECS and ENS, we describe a few representative examples where nature uses ENS, as a rule of life, to create the ensembles of biomacromolecules for emergent properties/functions in a myriad of cellular processes. Then, we focus on ENS of man-made (synthetic) molecules in cell-free conditions, classified by the types of enzymes. After that, we introduce the exploration of ENS of man-made molecules in the context of cells by discussing intercellular, peri/intracellular, and subcellular ENS for cell morphogenesis, molecular imaging, cancer therapy, and other applications. Finally, we provide a perspective on the promises of ENS for developing molecular assemblies/processes for functions. This review aims to be an updated introduction for researchers who are interested in exploring noncovalent synthesis for developing molecular science and technologies to address societal needs.

show abstract

Section: Coupling With Other Controlling Mechanisms-mentioning

confidence: 99%

Section: Coupling With Other Controlling Mechanisms-mentioning

confidence: 99%