Kurative und diagnostische Resektionen an der Leber

Mantke, René; Niepmann, D.; Gastinger, I.; Lippert, H.; Koch, Klaus Peter; Quehl, A.

doi:10.1007/s00104-006-1247-7

Cited by 9 publications

(1 citation statement)

References 28 publications

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“…Das Steigerungspotenzial dieser Gruppe wird kontrovers diskutiert. Der weiter oben genannten Quote von rund 15-20 % an primär resektablen kolorektalen Lebermetastasen stehen nur knapp 9% realisierter kurativer anatomischer Leberteilresektionen gegenüber, wie aus einer 2006 beschriebenen Datenanalyse des Tumorzentrums Brandenburg hervorgeht[9]. Extrapoliert man diese Zahlen auf die RFA, sind Indikationen bei ca.…”

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Die Radiofrequenzablation in der Behandlung von kolorektalen Lebermetastasen: Was ist belegt?

et al. 2013

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Radiofrequency ablation (RFA) of colorectal liver metastases is frequently reported, but, however, lacks clear criteria for indication and reliable, convincing results with 5-year survival ranging from 17 to 48 %. RFA may be the appropriate treatment modality in approximately 3 to 5 % of all patients suffering from colorectal liver metastases. To date, RFA seems to be limited to no more than three metastases, each smaller than 3 cm. The main indication remains irresectability due to number, site, distribution and/or marginal liver function. Tumours in the vicinity of larger vessels (predominantly branches of portal or hepatic veins) are a case for controversy, since advances in hepatobiliary surgery enable a proportion of patients to undergo resections which would have been declared irresectable until most recently, and the oncological value of a thermoablation is questioned, as a certain amount of temperature is lost due to convective heat sinks. RFA is not a curative alternative to hepatic resection unless small tumours appear during open or laparoscopic procedures in a patient with elevated risk for early recurrence or postoperative morbidity following liver resection. The inclusion of RFA into a holistic system of oncological therapy is mandatory. Early RFA followed by systemic (regional?) chemotherapy can rather be recommended than chemo only, RFA only or first-line chemo with subsequent RFA.

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Die Radiofrequenzablation in der Behandlung von kolorektalen Lebermetastasen: Was ist belegt?

et al. 2013

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Prospective study of bone scintigraphy as a staging investigation for oesophageal carcinoma

Jennings

Griffin

Lamb

et al. 2008

British Journal of Surgery

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Hospital volume and mortality in liver resections for colorectal metastasis using population‐based administrative data

Hunger

Mantke

Herrmann

et al. 2019

J Hepato Biliary Pancreat

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Background Approximately one‐quarter of patients with colorectal carcinoma develop colorectal liver metastases (CRLM). Surgical treatment with curative intent by hepatic resection is the standard medical care. While some studies with small sample sizes have investigated the relationship between hospital procedure volume and in‐hospital mortality for this diagnosis, no population‐based study has been conducted. The present study was aimed at closing this gap. Methods Based on administrative population‐based hospital discharge data (Diagnosis Related Group Statistic), patients diagnosed with CRLM and treated with hepatic resection from 2011 to 2015 were identified. The hospital operation‐volume effect on risk‐adjusted in‐hospital mortality was examined by logistic regression models. Results During the study period, 5900 patients with CRLM were treated with hepatic resection, of whom 189 (3.2%) died before hospital discharge. Hospitals of different operation‐volume quartiles did not differ in terms of mortality rates. Sensitivity analysis investigating the volume–mortality relationship separately for every resection procedure showed no clear result. Procedure frequencies vary among hospitals of different volume quartiles, with low‐volume hospitals performing systematically more low‐risk procedures (in terms of reduced mortality rate), than high‐volume hospitals. Conclusion Based on almost complete German hospital discharge data, the results did not confirm unconditional volume–outcome relationship for CRLM patients.

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Kurative und diagnostische Resektionen an der Leber

Cited by 9 publications

References 28 publications

Die Radiofrequenzablation in der Behandlung von kolorektalen Lebermetastasen: Was ist belegt?

Die Radiofrequenzablation in der Behandlung von kolorektalen Lebermetastasen: Was ist belegt?

Prospective study of bone scintigraphy as a staging investigation for oesophageal carcinoma

Hospital volume and mortality in liver resections for colorectal metastasis using population‐based administrative data

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