Kyrieleis Plaques Associated With Acute Retinal Necrosis From Herpes Simplex Virus Type 2

Witmer, Matthew T.; Levy-Clarke, Grace A.; Fouraker, Bradley D.; Madow, Brian

doi:10.1097/icb.0b013e3181f66aac

Cited by 9 publications

(8 citation statements)

References 23 publications

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“…Their occurrence in ARN is rare. There is a single case report of Kyrieleis plaques in ARN due to HSV-2, 8 and two reports in ARN due to VZV 9, 10. To the best of our knowledge, this is the first report of Kyrieleis plaques in ARN due to HSV-1.…”

Section: Discussionmentioning

confidence: 76%

Kyrieleis plaques associated with Herpes Simplex Virus type 1 acute retinal necrosis

Goel

Sawhney

2016

Saudi Journal of Ophthalmology

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We report the case of a 55-year-old immunocompetent male who presented with features typical of acute retinal necrosis (ARN). Polymerase chain reaction of the aqueous tap was positive for Herpes Simplex Virus (HSV) - 1. Following therapy with intravenous Acyclovir, followed by oral Acyclovir and steroids, there was marked improvement in the visual acuity and clinical picture. At one week after initiation of treatment, Kyrieleis plaques were observed in the retinal arteries. They became more prominent despite resolution of the vitritis, retinal necrosis and vasculitis and persisted till six weeks of follow-up, when fluorescein angiography was performed. The appearance of this segmental retinal periarteritis also known as Kyrieleis plaques has not been described in ARN due to HSV-1 earlier.

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Section: Discussionmentioning

confidence: 76%

Kyrieleis plaques associated with Herpes Simplex Virus type 1 acute retinal necrosis

Goel

Sawhney

2016

Saudi Journal of Ophthalmology

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“…Only few cases have been reported in literature [ 4 ]. This rare condition has been reported particularly in association with infectious posterior uveitis: toxoplasmosis [ 5 ], syphilis [ 6 ], Mediterranean spotted fever [ 7 ], acute retinal necrosis due to HSV-2 [ 8 ], and VZV [ 9 ], but has also been described in posterior uveitis with inflammatory origin: Behçet disease and sarcoidosis [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

Kyrieleis arteritis associated with toxoplasmic retinochoroiditis: A case report

Mahjoub

Abdesslem

Zaafrane

et al. 2022

Annals of Medicine &Amp; Surgery

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“…Pichi et al conducted a multimodal imaging study of 25 eyes with Kyrieleis arteritis and suggested that Kyrieleis plaques represent an inflammatory process within the vessel wall and most probably the endothelium. Full-thickness involvement of the vessel wall is highly unlikely, as indicated by the absence of leakage in fluorescein angiography [ 8 , 9 ]. Kyrieleis arteriolitis has primarily been associated with ocular toxoplasmosis, but it has also been described in tuberculosis, syphilis, acute retinal necrosis, cytomegalovirus retinitis and Mediterranean spotted fever as well as in noninfectious diseases such as Behçet’s disease and Susac’s syndrome [ 10 , 11 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

Kyrieleis Arteriolitis Associated with Acute Retinal Necrosis Due to Herpes Simplex Virus Type 1 Secondary to Herpetic Encephalitis

Makri

Tsekouras

Leonidou

et al. 2022

Vision

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We report the case of a 52-year-old woman who presented to the emergency department with acute retinal necrosis in her left eye secondary to herpes simplex virus type 1 encephalitis for which she had been hospitalized four months before. Treatment with intravitreal foscarnet and intravenous acyclovir was promptly commenced followed by the addition of oral prednisolone. PCR analysis of aqueous humor detected HSV type 1 DNA. The condition responded to therapy with partial resolution of intraocular inflammation and improvement of visual acuity, but the presence of Kyrieleis plaques was observed two weeks after the initiation of treatment, when five intravitreal foscarnet injections had been administered. The patient was switched to oral therapy with valacyclovir, and 10 weeks after commencing treatment, the patient’s left eye was free of inflammation, having achieved a BCVA of 20/20. Oral steroid treatment was gradually tapered off, and the patient was instructed to remain on prophylactic antiviral therapy. Kyrieleis arteriolitis is an uncommon finding in the context of acute retinal necrosis. As far as we are aware, we report the first case of Kyrieleis arteriolitis in acute retinal necrosis secondary to viral encephalitis and the second one presenting Kyrieleis plaques in acute retinal necrosis caused by herpes simplex virus type 1. Prior reports of cases of Kyrieleis arteriolitis in acute retinal necrosis are also presented.

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Kyrieleis Plaques Associated With Acute Retinal Necrosis From Herpes Simplex Virus Type 2

Cited by 9 publications

References 23 publications

Kyrieleis plaques associated with Herpes Simplex Virus type 1 acute retinal necrosis

Kyrieleis plaques associated with Herpes Simplex Virus type 1 acute retinal necrosis

Kyrieleis arteritis associated with toxoplasmic retinochoroiditis: A case report

Kyrieleis Arteriolitis Associated with Acute Retinal Necrosis Due to Herpes Simplex Virus Type 1 Secondary to Herpetic Encephalitis

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