L’altération de la perméabilité intestinale : chaînon manquant entre dysbiose et inflammation au cours de l’obésité ?

Genser, Laurent; Poitou, Christine; Brot-Laroche, Édith; Rousset, Monique; Clément, Karine; Thenet, Sophie; Leturque, Armelle

doi:10.1051/medsci/20163205012

Cited by 11 publications

(4 citation statements)

References 45 publications

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“…Restoration of intestinal permeability may be related to the relief of the inflammation reaction ( 21 ). Therefore, the effect of B. subtilis administration on gut inflammation was explored using ELISA.…”

Section: Resultsmentioning

confidence: 99%

Mucosa-reparing and microbiota-balancing therapeutic effect of Bacillus subtilis alleviates dextrate sulfate sodium-induced ulcerative colitis in mice

Zhang

et al. 2016

Experimental and Therapeutic Medicine

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Gut microbiota composition of patients with ulcerative colitis (UC) is markedly altered compared with healthy individuals. There is mounting evidence that probiotic therapy alleviates disease severity in animal models and patients with inflammatory bowel disease (IBD). Bacillus subtilisis, as a probiotic, has also demonstrated a protective effect in IBD. However, the therapeutic mechanism of its action has yet to be elucidated. In the present study, a dextrose sulfate sodium (DSS)-induced UC mouse model was used to investigate the role of B. subtilis in the restoration of gut flora and determine its effective dose. Mucosal damage was assessed by performing alcian blue staining, cytokine levels were analyzed by ELISA and microbiota composition was investigated using 454 pyrosequencing to target hypervariable regions V3-V4 of the bacterial 16S ribosomal RNA gene. The results demonstrated that a higher dose B. subtilisis administration ameliorated DSS-induced dysbiosis and gut inflammation by balancing beneficial and harmful bacteria and associated anti- and pro-inflammatory agents, thereby aiding intestinal mucosa recovery from DSS-induced injuries. These findings indicate that choosing the correct dose of B. subtilis is important for effective UC therapy. The present study also helped to elucidate the mechanisms of B. subtilis action and provided preclinical data for B. subtilis use in UC therapy.

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Section: Resultsmentioning

confidence: 99%

Mucosa-reparing and microbiota-balancing therapeutic effect of Bacillus subtilis alleviates dextrate sulfate sodium-induced ulcerative colitis in mice

Zhang

et al. 2016

Experimental and Therapeutic Medicine

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“…Impairments of epithelial barrier function are correlated with alterations in the structure and localization of TJ proteins, ZO-1 and occludin 125. In addition, an imbalance in the Firmicutes/Bacteroidetes ratio contributes to alterations in the expression of TJ proteins 126.…”

Section: New Pathways To Prevent Intestinal Permeability Alterations mentioning

confidence: 99%

<p>Beneficial effects of <em>Saccharomyces boulardii</em> CNCM I-745 on clinical disorders associated with intestinal barrier disruption</p>

Terciolo¹,

Dapoigny²,

André³

2019

CEG

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Intestinal barrier defects lead to “leaky gut syndrome”, defined as an increase in intestinal permeability that allows the passage of luminal content into intestinal tissue and the bloodstream. Such a compromised intestinal barrier is the main factor underlying the pathogenesis of inflammatory bowel disease, but also commonly occurs in various systemic diseases such as viral infections and metabolic syndrome. The non-pathogenic yeast Saccharomyces boulardii CNCM I-745 has demonstrated its effectiveness as a probiotic in the prevention and treatment of antibiotic-associated, infectious and functional diarrhea. Via multiple mechanisms of action implicated in intestinal barrier function, S. boulardii has beneficial effects on altered intestinal microbiota and epithelial barrier defects in different pathologies. The well-studied probiotic yeast S. boulardii plays a crucial role in the preservation and/or restoration of intestinal barrier function in multiple disorders. This could be of major interest in diseases characterized by alterations in intestinal barrier function.

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“…Today, there are more and more proofs that metabolites of the intestinal bacteria reach the circulation through the destroyed intestinal barrier during inflammation [ 98 , 99 , 100 , 101 ]. Thaiss and co-authors highlight three factors affecting microbiome-mediated diseases at the same time [ 102 ].…”

Section: Intestinal Microbiota In Neuroimmune Network Formationmentioning

confidence: 99%

The Neuroimmune Role of Intestinal Microbiota in the Pathogenesis of Cardiovascular Disease

Suslov

Chairkina

Shepetovskaya

et al. 2021

JCM

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Currently, a bidirectional relationship between the gut microbiota and the nervous system, which is considered as microbiota-gut-brain axis, is being actively studied. This axis is believed to be a key mechanism in the formation of somatovisceral functions in the human body. The gut microbiota determines the level of activation of the hypothalamic–pituitary system. In particular, the intestinal microbiota is an important source of neuroimmune mediators in the pathogenesis of cardiovascular disease. This review reflects the current state of publications in PubMed and Scopus databases until December 2020 on the mechanisms of formation and participation of neuroimmune mediators associated with gut microbiota in the development of cardiovascular disease.

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L’altération de la perméabilité intestinale : chaînon manquant entre dysbiose et inflammation au cours de l’obésité ?

Cited by 11 publications

References 45 publications

Mucosa-reparing and microbiota-balancing therapeutic effect of Bacillus subtilis alleviates dextrate sulfate sodium-induced ulcerative colitis in mice

Mucosa-reparing and microbiota-balancing therapeutic effect of Bacillus subtilis alleviates dextrate sulfate sodium-induced ulcerative colitis in mice

<p>Beneficial effects of <em>Saccharomyces boulardii</em> CNCM I-745 on clinical disorders associated with intestinal barrier disruption</p>

The Neuroimmune Role of Intestinal Microbiota in the Pathogenesis of Cardiovascular Disease

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