L’aniridie : à propos de cinq observations

The foveal region contains the highest cell density in the human retina; consequently a disproportionately large area of the visual cortex is dedicated to its representation. In aniridia and albinism the fovea does not develop, and the corresponding cortical representation shows a reduction in gray matter volume. In albinos there are chiasmatic irregularities in the hemispheric projections, which are not found in aniridics. Here, we ask whether the anomalies in central retinal development, present in albinism and aniridia, have a wider impact on the architecture of the visual cortex. The length, depth, and topology of the calcarine fissure is analyzed in albino, aniridic, and normal subjects. These measures are compared between groups and between the cortical hemispheres within each subject. We show that the calcarine fissure, where the primary visual cortex is represented, is abnormally short in those lacking a fovea. Moreover, surface reconstructions of the calcarine fissure revealed marked interhemispheric asymmetries. The two groups could not be distinguished on the basis of their cortical features, and we therefore interpret the abnormalities in cortical architecture in terms of the absence of the fovea, the common retinal feature found in both groups.

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The fovea regulates symmetrical development of the visual cortex

Neveu

Hagen

Morland

et al. 2007

J of Comparative Neurology

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Implants à iris artificiel dans la correction des aniridies ou des déficiences iriennes fonctionnelles

Roman¹,

Cherrate²,

Trouvet³

et al. 2009

Journal Français d'Ophtalmologie

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Autologous Serum Eyedrops in the Treatment of Aniridic Keratopathy

et al. 2008

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L’aniridie : à propos de cinq observations

Cited by 5 publications

References 20 publications

The fovea regulates symmetrical development of the visual cortex

The fovea regulates symmetrical development of the visual cortex

Implants à iris artificiel dans la correction des aniridies ou des déficiences iriennes fonctionnelles

Autologous Serum Eyedrops in the Treatment of Aniridic Keratopathy

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