2000
DOI: 10.1016/s0929-693x(00)80134-7
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L'antibiothérapie dans la mucoviscidose

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Cited by 7 publications
(3 citation statements)
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References 82 publications
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“…Using a fully factorial design, we created experimental source-sink systems in which we tested four daily immigration treatments (10, 1.0, 0.1 and 0% cells transferred from a non-evolving source population) on five antibiotic treatments. We used in the order of increasing harshness; streptomycin only, rifampicin only; two combinations of cycling therapy (alternating the two antibiotics; Raymond et al 2001;Gruson et al 2003); and bi-therapy (exposure to two antibiotics simultaneously; Sermet-Gaudelus et al 2000;Châtain 2003). We replicated each treatment 12 times for a total of 240 independent sink microcosms.…”
Section: Introductionmentioning
confidence: 99%
“…Using a fully factorial design, we created experimental source-sink systems in which we tested four daily immigration treatments (10, 1.0, 0.1 and 0% cells transferred from a non-evolving source population) on five antibiotic treatments. We used in the order of increasing harshness; streptomycin only, rifampicin only; two combinations of cycling therapy (alternating the two antibiotics; Raymond et al 2001;Gruson et al 2003); and bi-therapy (exposure to two antibiotics simultaneously; Sermet-Gaudelus et al 2000;Châtain 2003). We replicated each treatment 12 times for a total of 240 independent sink microcosms.…”
Section: Introductionmentioning
confidence: 99%
“…Tratamiento [14,15,[22][23][24] Principios Las recomendaciones se basan actualmente en el consenso de expertos [14,15] . El tratamiento es coordinado por el Centro de Fibrosis Quística (CFQ), que permite la colaboración entre gastroenterólogos, neumólogos, otorrinolaringólogos (ORL), microbiólogos, kinesiterapeutas, psicólogos y dietistas.…”
Section: Otras Manifestacionesunclassified
“…La necesidad de obtener in situ concentraciones de antibióticos superiores a 10 veces la CMI ha conducido a nuevas modalidades terapéuticas [22] . Los aminoglucósidos con actividad dependiente de la concentración se administran en dosis única diaria (DUD).…”
Section: Generalidadesunclassified