l-Arginine Grafted Poly(Glycerol Sebacate) Materials: An Antimicrobial Material for Wound Dressing

Wang, Chia-Chun; Shih, Ting‐Yu; Hsieh, Yi‐Ting; Huang, Jie-Len; Wang, Jane

doi:10.3390/polym12071457

Cited by 9 publications

(5 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The system was considered a potential candidate for drug application and dressings [45]. L-arginine-modified PGS films showed a low water vapor transmission rate and antimicrobial effect, being reported as a new dressing for the treatment of dermal wounds [46].…”

Section: Healing Activitymentioning

confidence: 99%

Biodegradable synthetic polymers in biomedical application: A review

Souza¹,

Granja²,

Melo³

et al. 2022

Braz. J. Hea. Rev.

View full text Add to dashboard Cite

Biotechnology associated with medical technology has allowed biodegradable synthetic polymers to have versatile and diversified biomedical applications due to interesting properties such as good cell adhesion, in vivo proliferation, and degradation without harmful effects to the human body. Thus, they are suitable for a variety of applications, especially those related to therapeutics or pharmaceutics, for example, tissue engineering and drug delivery. This work aimed to revise the broad applications of the term biodegradation in different areas of science. We focused on the most recent biomedical applications of biodegradable synthetic polymers, revising the characteristics which have contributed to solving health-related problems. Actual, efficient, and consistent results have been introduced in the market as a result of the growing search for new technologies. They have been applied both at macro and nanometer scales, in isolated and conjugated forms, or even as encapsulating matrices. Biodegradable synthetic polymers present longer degradation periods when compared to natural polymers, they stand out in tissue engineering since they can be adjusted according to their composition, reaching various degrees of selectivity for specific clinical applications.

show abstract

Section: Healing Activitymentioning

confidence: 99%

Biodegradable synthetic polymers in biomedical application: A review

Souza¹,

Granja²,

Melo³

et al. 2022

Braz. J. Hea. Rev.

View full text Add to dashboard Cite

show abstract

“…31 Herein, the possible antimicrobial effects of p(L-Arg) particles against E. coli ATCC 8739 (GramÀ), P. aeruginosa ATCC 10145 (GramÀ), S. aureus ATCC 6538 (Gram +), B. subtilis ATCC 6633 (Gram+) bacteria, and C. albicans ATCC 10231 yeast strain were investigated as are the most common microbes causing infections of wounds. 65 The results of the disc diffusion test are summarized in Table 3. Inhibition zone diameters (mm) for 10 mg gentamicin as a standard against E. coli, P. aeruginosa, S. aureus, and 4.…”

Section: Antimicrobial Effect Of P(l-arg) Particlesmentioning

confidence: 99%

One step synthesis of an amino acid derived particles, poly(L‐Arginine) and its biomedical application

Şahiner

2021

Polymers for Advanced Techs

View full text Add to dashboard Cite

Herein, single step synthesis of poly(L-Arginine) (p(L-Arg)) particles was reported for the first time via microemulsion crosslinking method using tetrakis(hydroxymethyl) phosphonium chloride (THPC) as the crosslinking agent. The C-P vibrational FT-IR peaks of the p(L-Arg) particles observed at 1035 cm À1 as well as elemental analysis results corroborated the successful crosslinking of native L-Arg molecules with THCP. Spherical-shaped p(L-Arg) particles visualized by SEM analysis ranged 1-10 μm in size in dry state. The important parameters of p(L-Arg) particles affecting their biomedical potential use such as degradability, blood compatibility, antioxidant and antimicrobial properties were thoroughly investigated. Accordingly, 49.2 ± 6.7%, 68.1 ± 4.8%, and 62.5 ± 7.1% of the p(L-Arg) particles were degraded at pH 5.4, 7.4, and 9.0, respectively, in about 200 h. The p(L-Arg) particles exhibited fascinating blood compatibility with less than 4% hemolysis induction and more than 95% blood clotting index at 2 mg/mL concentration. The antioxidant activity of p(L-Arg) particles was measured as 0.66 ± 0.06 μM Trolox equivalent g À1 by means of TEAC assay.Moreover, the antimicrobial activity of L-Arg amino acid against Escherichia coli ATCC 8739, Pseudomonas aeruginosa ATCC 10145, gram-positive Staphylococcus aureus ATCC 6538, B. subtilis ATCC 6633 bacteria, and Candida albicans ATCC 10231 yeast strains was significantly enhanced in the form of p(L-Arg) particles. Furthermore, drug loading and release performances of p(L-Arg) particles were also investigated using naproxen and riboflavin as active pharmaceuticals. Based on drug release studies performed in PBS at pH 7.4, 73.9 ± 12.6% of loaded naproxen was released in 90 min, whereas 62.1 ± 4.6% of loaded riboflavin was released in 135 min.

show abstract

“…The introduction of Boc-L-glutamic acid increases the hydrophilicity and degradation rate for poly(xylitol glutamate sebacate) [ 34 ]. PGS has been endowed with antimicrobial capacity by grafting L-arginine [ 35 ]. Photocurable PGS prepolymer has been prepared using methacrylic anhydride to be used in additive manufacturing [ 36 ].…”

Section: Introductionmentioning

confidence: 99%

Incorporation of Glutamic Acid or Amino-Protected Glutamic Acid into Poly(Glycerol Sebacate): Synthesis and Characterization

Jiang

Jan

et al. 2022

Polymers

View full text Add to dashboard Cite

Poly(glycerol sebacate) (PGS), a soft, tough elastomer with excellent biocompatibility, has been exploited successfully in many tissue engineering applications. Although tunable to some extent, the rapid in vivo degradation kinetics of PGS is not compatible with the healing rate of some tissues. The incorporation of L-glutamic acid into a PGS network with an aim to retard the degradation rate of PGS through the formation of peptide bonds was conducted in this study. A series of poly(glycerol sebacate glutamate) (PGSE) containing various molar ratios of sebacic acid/L-glutamic acid were synthesized. Two kinds of amino-protected glutamic acids, Boc-L-glutamic acid and Z-L-glutamic acid were used to prepare controls that consist of no peptide bonds, denoted as PGSE-B and PGSE-Z, respectively. The prepolymers were characterized using 1H-NMR spectroscopy. Cured elastomers were characterized using FT-IR, DSC, TGA, mechanical testing, and contact angle measurement. In vitro enzymatic degradation of PGSE over a period of 28 days was investigated. FT-IR spectroscopy confirmed the formation of peptide bonds. The glass transition temperature for the elastomer was found to increase as the ratio of sebacic acid/glutamic acid was increased to four. The decomposition temperature of the elastomer decreased as the amount of glutamic acid was increased. PGSE exhibited less stiffness and larger elongation at break as the ratio of sebacic acid/glutamic acid was decreased. Notably, PGSE-Z was stiffer and had smaller elongation at break than PGSE and PGSE-B at the same molar ratio of monomers. The results of in vitro enzymatic degradation demonstrated that PGSE has a lower degradation rate than does PGS, whereas PGSE-B and PGSE-Z degrade at a greater rate than does PGS. SEM images suggest that the degradation of these crosslinked elastomers is due to surface erosion. The cytocompatibility of PGSE was considered acceptable although slightly lower than that of PGS. The altered mechanical properties and retarded degradation kinetics for PGSE reflect the influence of peptide bonds formed by the introduction of L-glutamic acid. PGSE displaying a lower degradation rate compared to that for PGS can be used as a scaffold material for the repair or regeneration of tissues that are featured by a low healing rate.

show abstract

l-Arginine Grafted Poly(Glycerol Sebacate) Materials: An Antimicrobial Material for Wound Dressing

Cited by 9 publications

References 22 publications

Biodegradable synthetic polymers in biomedical application: A review

Biodegradable synthetic polymers in biomedical application: A review

One step synthesis of an amino acid derived particles, poly(L‐Arginine) and its biomedical application

Incorporation of Glutamic Acid or Amino-Protected Glutamic Acid into Poly(Glycerol Sebacate): Synthesis and Characterization

Contact Info

Product

Resources

About