L-band Overhauser dynamic nuclear polarization

García, Sandra G.; Walton, Jeffrey H.; Armstrong, Brandon D.; Han, Songi; McCarthy, Michael J.

doi:10.1016/j.jmr.2009.12.012

Cited by 17 publications

(18 citation statements)

References 38 publications

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“…Theoretical principles of OMRI are well documented [26][27][28]. Nevertheless, a brief outline of the principles relevant to the experiments reported herein is presented in this section.…”

Section: Theorymentioning

confidence: 99%

Dynamic nuclear polarization properties of nitroxyl radical in high viscous liquid using Overhauser-enhanced Magnetic Resonance Imaging (OMRI)

Dhas¹,

Utsumi

Jawahar³

et al. 2015

Journal of Magnetic Resonance

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“…Theoretical principles of OMRI are well documented [26][27][28]. Nevertheless, a brief outline of the principles relevant to the experiments reported herein is presented in this section.…”

Section: Theorymentioning

confidence: 99%

Dynamic nuclear polarization properties of nitroxyl radical in high viscous liquid using Overhauser-enhanced Magnetic Resonance Imaging (OMRI)

Dhas¹,

Utsumi

Jawahar³

et al. 2015

Journal of Magnetic Resonance

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“…Fitting the ε Max versus concentration has been previously been used to extrapolate the coupling factor at 40 mT . The assumptions to support this are as follows: (a) that S max → 1 as concentration increases and (b) Heisenberg spin exchange effects (HE) always increase measured DNP enhancements.…”

Section: Discussionmentioning

confidence: 99%

“…There is an extensive literature on the theoretical background for general OE‐DNP, which has been recently reviewed . Nitroxides are the class of radicals most studied for solution DNP and for these radicals Equation is an oversimplification. The complicating factor is the presence of a 14 N nucleus ( I = 1) in the nitroxide structure, which splits the electron paramagnetic resonance (EPR) transition into three hyperfine lines.…”

Section: Introductionmentioning

confidence: 99%

A table‐top PXI based low‐field spectrometer for solution dynamic nuclear polarization

Biller

Stupic

Moreland

2017

Magnetic Reson in Chemistry

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We present the development of a portable dynamic nuclear polarization (DNP) instrument based on the PCI eXtensions for Instrumentation platform. The main purpose of the instrument is for study of H polarization enhancements in solution through the Overhauser mechanism at low magnetic fields. A DNP probe set was constructed for use at 6.7 mT, using a modified Alderman-Grant resonator at 241 MHz for saturation of the electron transition. The solenoid for detection of the enhanced H signal at 288 kHz was constructed with Litz wire. The largest observed H enhancements (ε) at 6.7 mT for N-CTPO radical in air saturated aqueous solution was ε~65. A concentration dependence of the enhancement is observed, with maximum ε at 5.5 mM. A low resonator efficiency for saturation of the electron paramagnetic resonance transition results in a decrease in ε for the 10.3 mM sample. At high incident powers (42 W) and long pump times, capacitor heating effects can also decrease the enhancement. The core unit and program described here could be easily adopted for multi-frequency DNP work, depending on available main magnets and selection of the "plug and play" arbitrary waveform generator, digitizer, and radiofrequency synthesizer PCI eXtensions for Instrumentatione cards.

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“…Therefore, the deuterated nitroxyl radicals have been used as spin probes in ESR and OMR studies . The effect of molecular mobility upon enhancement of the NMR signal through DNP has been studied by several authors . These results motivated us to explore the ESR properties of deuterated and undeuterated nitroxyl radicals.…”

Section: Introductionmentioning

confidence: 99%

Electron spin resonance studies on deuterated nitroxyl spin probes used in Overhauser‐enhanced magnetic resonance imaging

Jebaraj

Utsumi

Benial³

2017

Magnetic Reson in Chemistry

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The electron spin resonance studies were carried out for 2 mm concentration of N-labeled and N-labeled 3-carbamoyl-2,2,5,5-tetramethyl-pyrrolidine-1-oxyl, 3-carboxy-2,2,5,5-tetramethyl-pyrrolidine-1-oxyl, 3-methoxycarbonyl-2,2,5,5-tetramethyl-pyrrolidine-1-oxyl and their deuterated nitroxyl radicals using X-band electron spin resonance spectrometer. The electron spin resonance line shape analysis was carried out. The electron spin resonance parameters such as linewidth, Lorentzian component, signal intensity ratio, rotational correlation time, hyperfine coupling constant and g-factor were estimated. The deuterated nitroxyl radicals have narrow linewidth and an increase in Lorentzian component, compared with undeuterated nitroxyl radicals. The dynamic nuclear polarization factor was observed for all nitroxyl radicals. Upon H labeling, about 70% and 40% increase in dynamic nuclear polarization factor were observed for N-labeled and N-labeled nitroxyl radicals, respectively. The signal intensity ratio and g-value indicate the isotropic nature of the nitroxyl radicals in pure water. Therefore, the deuterated nitroxyl radicals are suitable spin probes for in vivo/in vitro electron spin resonance and Overhauser-enhanced magnetic resonance imaging modalities. Copyright © 2017 John Wiley& Sons, Ltd.

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L-band Overhauser dynamic nuclear polarization

Cited by 17 publications

References 38 publications

Dynamic nuclear polarization properties of nitroxyl radical in high viscous liquid using Overhauser-enhanced Magnetic Resonance Imaging (OMRI)

Dynamic nuclear polarization properties of nitroxyl radical in high viscous liquid using Overhauser-enhanced Magnetic Resonance Imaging (OMRI)

A table‐top PXI based low‐field spectrometer for solution dynamic nuclear polarization

Electron spin resonance studies on deuterated nitroxyl spin probes used in Overhauser‐enhanced magnetic resonance imaging

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