L-Carnitine supplementation ameliorates serum tumor necrosis factor-alpha and matrix metalloproteinase-3 in knee osteoarthritis women

Mahdavi, Reza; Kolahi, Sousan; Attari, Vahideh Ebrahimzadeh; Mahdavi, Aida Malek

doi:10.3329/bjp.v12i1.30417

Cited by 8 publications

(8 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Three studies were conducted to examine the average changes in reported l ‐carnitine supplement consumption on quality of life in people with OA in their knees. [ 24,26,27 ] For Figure 3c, the overall effect test result was ( Z = 1.87, p = 0.06). Figure 3c shows the variation in body weight between the trial group ( n = 90 participants: l ‐carnitine) and the control group ( n = 97 participants: placebo) relative to the first point (MD = −1.21, 95% CI [−4.25, 1.83]; Z = 0.78; p = 0.43).…”

Section: Resultsmentioning

confidence: 92%

“…A systematic review and meta‐analysis comprised four trials that examined the average changes in laboratory measurements in individuals with OA of the knee who were using l ‐carnitine supplementation. [ 22,24,26,27 ] For Figure 3 a, the whole overall effect test result was ( Z = 0.07, p = 0.95). The differences in high‐density lipoprotein cholesterol (HDL‐C) from baseline between the 67 participants in the l ‐carnitine experimental group and the 72 participants in the placebo‐control group are shown in Figure 3a (mean difference [MD] = −3.71, 95% CI [−7.90–0.48]; Z = 1.73; p = 0.08).…”

Section: Resultsmentioning

confidence: 93%

“…A systematic review and meta-analysis comprised four trials that examined the average changes in laboratory measurements in individuals with OA of the knee who were using l-carnitine supplementation. [22,24,26,27] For Figure 3a…”

Section: Laboratory Measurements In Patients With Changesmentioning

confidence: 99%

See 2 more Smart Citations

Effect of l‐Carnitine Supplementation on Osteoarthritis: A Systematic Review

Kou,

Li,

Wang

et al. 2024

Molecular Nutrition Food Res

View full text Add to dashboard Cite

ScopeComprehensive assessment of l‐carnitine's safety and effectiveness in reducing inflammatory markers in osteoarthritis (OA) patients.Methods and resultsJournal articles on l‐carnitine for OA are gathered using computer searches of PubMed, Embase, the Cochrane Library, and Web of Science. The kind of literature that is found is restricted to clinical randomized controlled trials (RCTs). The Cochrane Handbook risk of bias assessment tool RevMan 5.4 software is used to conduct a meta‐analysis. The systematic assessment comprises eight trials totaling 619 patients; the included studies’ quality is mediocre. The study's findings demonstrate that OA patients’ Western Ontario and McMaster University (WOMAC) function improves and that treatment efficacy outperforms that of the control group (mean difference [MD] = −7.75, 95% CI [−14.63, −0.86]; Z = 2.21; p = 0.03), WOMAC total (MD = −10.24, 95% CI [−18.97, −1.51]; Z = 2.30; p = 0.02), and visual analogue scale (VAS) pain (MD = −14.01, 95% CI [−16.16, −11.85]; Z = 12.74; p < 0.00001). The studies that are methodically reviewed also discover heterogeneity, which may have resulted from the created pooled data and requires more analysis.ConclusionIn patients with OA, l‐carnitine effectively decreases clinical signs and symptoms, inflammatory markers, pain, and stiffness indicators, and significantly improves WOMAC and VAS scores.

show abstract

Section: Resultsmentioning

confidence: 92%

Section: Resultsmentioning

confidence: 93%

See 1 more Smart Citation

Effect of l‐Carnitine Supplementation on Osteoarthritis: A Systematic Review

Kou,

Li,

Wang

et al. 2024

Molecular Nutrition Food Res

View full text Add to dashboard Cite

show abstract

“…Also, Abd-Allah et al showed that administration of lcar returned testicular NO and serum IL-2 to normal levels in a lipopolysaccharide model of sepsis [82]. Another evidence indicated that l-car supplementation has benefcial efects on reducing TNF-α levels in knee osteoarthritis patients [91]. More correlational evidence pointed out that lcar administration in drinking water signifcantly decreased the bleomycin-induced elevations of serum TNF-alpha and LPO level in lung tissues [92].…”

Section: Discussionmentioning

confidence: 99%

L-Carnitine Prevents Behavioural Alterations in Ketamine-Induced Schizophrenia in Mice: Possible Involvement of Oxidative Stress and Inflammation Pathways

Ebrahimi

Ahangar

Zamani

et al. 2023

Journal of Toxicology

View full text Add to dashboard Cite

Schizophrenia is a chronic mental complaint known as cognitive impairment. There has been evidence that inflammation and oxidative stress play a main role in schizophrenia pathophysiology. This study aimed to investigate the effects of l-carnitine, as a potent antioxidant, on the treatment of behavioural and biochemical disturbances in mice with ketamine-induced schizophrenia. In this study, schizophrenia was induced in mice by ketamine (25 mg/kg/day, i.p). Before induction of schizophrenia, mice were treated with l-carnitine (100, 200, and 400 mg/kg/day, i.p). Then, behavioural impairments were evaluated by open field (OF) assessment and social interaction test (SIT). After brain tissue isolation, reactive oxygen species (ROS), glutathione concentration (GSH), lipid peroxidation (LPO), protein carbonyl oxidation, superoxide dismutase activity (SOD), and glutathione peroxidase activity (GPx) were assessed as oxidative stress markers. Furthermore, inflammatory biomarkers such as tumour necrosis factor alpha (TNF-α) and nitric oxide (NO) were evaluated in brain tissue. Our results showed ketamine increased inflammation and oxidative damage in brain tissue that was similar to behaviour disorders in mice. Interestingly, l-carnitine significantly decreased oxidative stress and inflammatory markers compared with ketamine-treated mice. In addition, l-carnitine prevented and reversed ketamine-induced alterations in the activities of SOD and GPx enzymes in mice’s brains. Also, improved performance in OFT (locomotor activity test) and SIT was observed in l-carnitine-treated mice. These data provided evidence that, due to the antioxidant and anti-inflammatory effects of l-carnitine, it has a neuroprotective effect on mice model of schizophrenia.

show abstract

“…Group of few other studies have demonstrated that LC is effective in reducing plasma as well as serum levels of TNF-α. 30,31 It can be suggested that LC produce anti-apoptotic effects at lower doses only just like TNF-α showed more apoptotic effects at lower doses. But the mechanism by which LC could inhibit TNF-α induced apoptotic effects in lower doses only is yet to be confirmed in further studies.…”

Section: Discussionmentioning

confidence: 99%

An in-vitro analysis of L-Carnitine mediated rescue of TNF-? induced apoptosis in mice oocytes

Sharma¹,

Rana

Halder³

et al. 2022

IJCBR

View full text Add to dashboard Cite

: Tumor necrosis factor-alpha (TNF-α) is a pro-inflammatory cytokine implicated in various physiological and pathological events. Carnitine is a quaternary amine which plays a significant role in fatty acid oxidation and is reported to produce antiapoptotic effects. Aim of this work was to study the effect of L-Carnitine (LC) on TNF-α induced apoptosis in mice oocytes. : Oocytes were isolated from super ovulated Swiss Albino mice and treated with different concentrations of TNF-α (0.1ng/ml, 1ng/ml, 10ng/ml, 100ng/ml) and LC (0.1mg/ml, 0.3mg/ml, 0.5mg/ml, 1.0 mg/ml). TUNEL Assay was done for the biochemical assessment of apoptosis.: Apoptotic indices with different doses of TNF-α (0.1ng/ml, 1ng/ml, 10ng/ml, 100 ng/ml) were 28.5%, 71.4%, 100%, 42.8% respectively. The concentration of TNF-α that produced the highest apoptotic index was 10ng/ml. LC alone in different doses (0.1mg/ml, 0.3mg/ml, 0.5mg/ml, 1.0 mg/ml) did not elicit any apoptotic signal. Further LC was added in different doses with 10ng/ml TNF-α to study the rate of apoptosis in mice oocytes. Apoptotic index with 10 ng/ml TNF-α and different doses of LC (0.1mg/ml, 0.3mg/ml, 0.5mg/ml, 1 mg/ml) were 25%, 37.5%, 50%, 62.5% respectively. The concentration of LC that reduced the apoptotic index to the maximum was 0.1mg/ml.: Present study could demonstrate the anti-apoptotic effect of LC against apoptotic effects of TNF-α in mice oocytes. The study presents preliminary data suggesting a possible therapeutic role of LC in inflammatory etiologies such as ovarian failure.

show abstract

L-Carnitine supplementation ameliorates serum tumor necrosis factor-alpha and matrix metalloproteinase-3 in knee osteoarthritis women

Cited by 8 publications

References 30 publications

Effect of l‐Carnitine Supplementation on Osteoarthritis: A Systematic Review

Effect of l‐Carnitine Supplementation on Osteoarthritis: A Systematic Review

L-Carnitine Prevents Behavioural Alterations in Ketamine-Induced Schizophrenia in Mice: Possible Involvement of Oxidative Stress and Inflammation Pathways

An in-vitro analysis of L-Carnitine mediated rescue of TNF-? induced apoptosis in mice oocytes

Contact Info

Product

Resources

About