L-Cysteine Containing Vitamin Supplement Which Prevents or Alleviates Alcohol-related Hangover Symptoms: Nausea, Headache, Stress and Anxiety

Eriksson, Caroline; Metsälä, Markus; Möykkynen, Tommi; Mäkisalo, Heikki; Kärkkäinen, Olli; Palmén, Maria; Salminen, Joonas E; Kauhanen, Jussi

doi:10.1093/alcalc/agaa082

Cited by 11 publications

(6 citation statements)

References 32 publications

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“…One recent study found that L-cysteine reduces symptoms of a hangover including nausea, headache and anxiety 10 . However, when reviewing current treatment strategies for hangover, most interventions rely on lessening symptom-based adverse effects.…”

Section: Introductionmentioning

confidence: 99%

The use of N-acetylcysteine in the prevention of hangover: a randomized trial

Coppersmith

Hudgins

Stoltzfus

et al. 2021

Sci Rep

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Hangovers resulting from alcohol intoxication can lead to adverse effects ranging from generalized discomfort and work-related absenteeism to emergency department visits from patients seeking symptomatic care. The purpose of this study was to evaluate the efficacy of a low dose (600–1800 mg) of N-Acetylcysteine (NAC) vs placebo on mitigating hangover symptoms. This was a randomized, double-blinded, placebo controlled crossover study involving 49 volunteers who consumed beer to obtain a breath alcohol content (BrAC) of 0.1 g/210L. The participants met on two separate occasions at which time they were given either NAC or placebo capsules. Opposing treatments were administered during the second encounter. The morning after the participant’s intoxication and treatment, a Hangover Symptom Scale Questionnaire was administered to determine subjective changes in hangover symptoms. Data was analyzed by self-control, comparing the participant’s hangover symptom severity when using NAC compared to placebo. No significant difference was found in the general distribution of total hangover scores (P = .45) (NAC = 10; Placebo = 13). There was also no significant difference found in the general distribution of specific hangover symptoms. However, a significant difference was found in the general distribution of total hangover difference scores based on gender (P = .04) (Female − 3.5; Male 2), specifically for nausea (P = .05) and weakness (P = .03). Although no difference was found in the general hangover scale scores, the study was suggestive of gender specific susceptibility with female participants having improved hangover symptoms after NAC use.

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Section: Introductionmentioning

confidence: 99%

The use of N-acetylcysteine in the prevention of hangover: a randomized trial

Coppersmith

Hudgins

Stoltzfus

et al. 2021

Sci Rep

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“…Indeed, two recent double blind placebo controlled studies found no significant effect of a hangover treatment consisting of L-cysteine. Scholey et al found no significant improvement of hangover severity after administering L-cysteine (650 mg) and B-and C-vitamins [82], and Eriksson et al also did not demonstrate a significant reduction in hangover severity after administering L-cysteine (600 mg and 1200 mg) [83,84]. The reported data from a clinical trial on www.clinicaltrials.gov showed that NAC had no significant effects on reducing hangover severity but did produce more adverse effects than placebo (clinicaltrials.gov identifier NCT02541422).…”

Section: Oxidative Stressmentioning

confidence: 99%

The Role of Alcohol Metabolism in the Pathology of Alcohol Hangover

Mackus

Loo

Garssen

et al. 2020

JCM

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The limited number of available studies that examined the pathology of alcohol hangover focused on biomarkers of alcohol metabolism, oxidative stress and the inflammatory response to alcohol as potentially important determinants of hangover severity. The available literature on alcohol metabolism and oxidative stress is reviewed in this article. The current body of evidence suggests a direct relationship between blood ethanol concentration and hangover severity, whereas this association is not significant for acetaldehyde. The rate of alcohol metabolism seems to be an important determinant of hangover severity. That is, fast elimination of ethanol is associated with experiencing less severe hangovers. An explanation for this observation may be the fact that ethanol—in contrast to acetaldehyde—is capable of crossing the blood–brain barrier. With slower ethanol metabolism, more ethanol is able to reach the brain and elicit hangover symptoms. Hangover severity was also significantly associated with biomarkers of oxidative stress. More oxidative stress in the first hours after alcohol consumption was associated with less severe next-day hangovers (i.e., a significant negative correlation was found between hangover severity and malondialdehyde). On the contrary, more oxidative stress at a later stage after alcohol consumption was associated with having more severe next-day hangovers (i.e., a significant positive correlation was found between hangover severity and 8-isoprostane). In conclusion, assessment of biomarkers of alcohol metabolism suggests that fast elimination of ethanol is associated with experiencing less severe hangovers. More research is needed to further examine the complex interrelationship between alcohol metabolism, the role of acetaldehyde and oxidative stress and antioxidants, and the pathology of the alcohol hangover.

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“…Modeling and analytical studies by Lewis, et al [28] suggest that a protonated Schiff base structure generated from acetaldehyde in vivo may be central to pathophysiological outcomes because it determines the structure of the stable covalent adduct formed. Also noteworthy are reports that the SH-containing amino acid L-cysteine alleviates the alcohol-related hangover symptoms of nausea, headache, stress and anxiety in humans [29]. We reported on the beneficial effects of L-cysteine in preventing food browning in fresh and dehydrated potatoes and in apples [30] [31], the reduction of adverse effects of acrylamide in frog embryos [32] [33], the inhibition of formation of the unnatural amino acid lysinoalanine in proteins [34] as well as on the antibiotic effects of cinnamaldehyde [35].…”

Section: Mechanistic Aspectsmentioning

confidence: 99%

A Bioprocessed Black Rice Bran Glutathione-Enriched Yeast Extract Protects Rats and Mice against Alcohol-Induced Hangovers

Kim¹,

Lee²,

Jang³

et al. 2021

FNS

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Human and animal alcohol-induced hangovers are caused by adverse effects of acetaldehyde formed in vivo by the enzymatic oxidation of ethyl alcohol to acetaldehyde. This study aims to determine the effect of the combination of a bioprocessed black rice bran (BRB-F) and glutathione-enriched yeast extract (GEYE) on hangovers as tested in rats and mice. Because analysis by HPLC showed that the content of the biologically active rice bran compound γ-oryzanol as well as of the antioxidant reduced glutathione were unaffected during the preparation of tablets containing 100 mg/kg of the bran formulation, the tablets were then administered orally to rats. The results showed decreased blood concentrations of both alcohol and acetaldehyde compared to the control group. Additional behavior experiments using the Rota-rod and wire tests in mice confirmed that the food formulation relieved hangover behavior caused by alcohol. It seems that the combination of BRB-F and GEYE can effectively control hangovers in rodents caused by alcohol intake. Mechanistic aspects of the hangover and anti-hangover effects of alcohol-derived acetaldehyde are similar to browning-type reactions between the aldehyde group of glucose and proteins, the antibiotic effects of cinnamaldehyde against pathogenic bacteria, the adverse effects of the heat-induced food toxin acrylamide, and the alkali-induced formation of the unnatural amino acid lysinoalanine.

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L-Cysteine Containing Vitamin Supplement Which Prevents or Alleviates Alcohol-related Hangover Symptoms: Nausea, Headache, Stress and Anxiety

Cited by 11 publications

References 32 publications

The use of N-acetylcysteine in the prevention of hangover: a randomized trial

The use of N-acetylcysteine in the prevention of hangover: a randomized trial

The Role of Alcohol Metabolism in the Pathology of Alcohol Hangover

A Bioprocessed Black Rice Bran Glutathione-Enriched Yeast Extract Protects Rats and Mice against Alcohol-Induced Hangovers

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