l-Glutamate-induced responses in OFF-type bipolar cells of the cat retina

Sasaki, Tsugihisa; Kaneko, Akimichi

doi:10.1016/0042-6989(95)00176-x

Cited by 55 publications

(29 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Stain concentrates in the dendritic tips and in the basal dendrites (presumably of OFF bipolar cells), and it associates with the postsynaptic electron-dense membrane. This distribution is consistent with physiological recordings from isolated OFF cone bipolar cells, because glutamate elicits a large response if it is applied focally to dendritic endings, but it elicits no response if it is applied to somata (Sasaki and Kaneko, 1996).…”

Section: Subcellular Distribution Of Subunit Proteins In Horizontal Csupporting

confidence: 67%

“…The receptor type that hyperpolarizes ON cells is known to be a retina-specific metabotropic receptor, metabotropic glutamate receptor 6 (mGluR6; Nomura et al, 1994;Ueda et al, 1997;Vardi and Morigiwa, 1997). The receptor types that depolarize OFF cone bipolar cells and horizontal cells clearly belong to a family of ionotropic glutamate receptors (iGluRs) of the ionotropic ␣-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and/or kainate types (O'Dell and Christensen, 1989;Kim and miller, 1991;Zhou et al, 1993;Krizaj et al, 1994;Sasaki and Kaneko, 1996). However, there are four isoforms of AMPA subunits (GluR1-GluR4) and five isoforms of kainate subunits (GluR5-GluR7 and KA1 and KA2), and each receptor is an oligomer composed of four of these subunits (for reviews, see Hollman and Heinemann, 1994;Hollman, 1997;Rosenmund et al, 1998).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Differential expression of ionotropic glutamate receptor subunits in the outer retina

1999

View full text Add to dashboard Cite

Section: Subcellular Distribution Of Subunit Proteins In Horizontal Csupporting

confidence: 67%

mentioning

confidence: 99%

Differential expression of ionotropic glutamate receptor subunits in the outer retina

1999

View full text Add to dashboard Cite

“…Mixed patterns of bipolar cell responses were induced by KA (Figs. 1, 2), as expected from electrophysiologic data showing that OFF-center bipolar cells preferentially bear classical ionotropic GluRs and are KA sensitive, whereas ON-center bipolar cells employ metabotropic GluRs and are predominantly KA insensitive Miller, 1981, 1983;Karschin and Wä ssle, 1990;Yamashita and Wä ssle, 1991;de la Villa et al, 1995;Euler et al, 1996;Hartveit, 1996Hartveit, , 1997Sasaki and Kaneko, 1996). The responses of OFF-center bipolar cells are strong and show more dispersion than horizontal cells.…”

Section: Ka Responses Of Bipolar Cellssupporting

confidence: 64%

Kainate activation of horizontal, bipolar, amacrine, and ganglion cells in the rabbit retina

Marc

1999

J. Comp. Neurol.

View full text Add to dashboard Cite

Patterns of excitation in populations of retinal bipolar, amacrine, and ganglion cells were mapped by activating α‐amino‐3‐hydroxyl‐5‐methylisoxazole‐4‐propionic acid (AMPA) and kainate (KA) receptors with KA in the presence of the channel‐permeant guanidinium analogue 1‐amino‐4‐guanidobutane (AGB). Registered serial thin sections were probed with immunoglobulins targeting AGB, glutamate, glycine, and γ‐aminobutyric acid (GABA) to visualize KA‐evoked responses and the neurochemical signatures of distinct cell types. OFF‐center cone bipolar cells and both type A and type B horizontal cells were strongly activated by KA. ON‐center cone bipolar cells displayed weak AGB signals that arose at least partially, if not entirely, from coupling with KA‐responsive glycinergic amacrine cells, whereas rod bipolar cells exhibited no detectable AGB permeation after KA activation. GABA‐positive amacrine cells displayed a range of KA responses, some possessing little AGB signal even after strong KA activation, whereas all identifiable glycine‐positive amacrine cells were driven by KA. Quantitative agonist responsivities of cells in the ganglion cell layer revealed that starburst amacrine cells are the most KA‐responsive cell type in that layer. Ganglion cells varied in KA responsivity across morphologic subtypes, with a large α‐like ganglion cell group the being the most KA responsive. Some ganglion cells displayed weak KA responses, even with saturating doses, that may have been be due to an absence of AMPA/KA receptors or to the existence of AGB‐impermeant AMPA/KA receptor complexes. J. Comp. Neurol. 407:65–76, 1999. © 1999 Wiley‐Liss, Inc.

show abstract

“…Physiological studies using isolated cells indicate that only µM levels of Glu are required to activate GluR [106][107][108] . Thus, the amount of Glu released into the synaptic cleft is several orders of magnitude higher than the concentration required for activating most postsynaptic receptors.…”

Section: ) Glutamatementioning

confidence: 99%

A Review of Glutamate Receptors I: Current Understanding of Their Biology

Rousseaux

2008

J Toxicol Pathol

View full text Add to dashboard Cite

Seventy years ago it was discovered that glutamate is abundant in the brain and that it plays a central role in brain metabolism. However, it took the scientific community a long time to realize that glutamate also acts as a neurotransmitter. Glutamate is an amino acid and brain tissue contains as much as 5 -15 mM glutamate per kg depending on the region, which is more than of any other amino acid. The main motivation for the ongoing research on glutamate is due to the role of glutamate in the signal transduction in the nervous systems of apparently all complex living organisms, including man. Glutamate is considered to be the major mediator of excitatory signals in the mammalian central nervous system and is involved in most aspects of normal brain function including cognition, memory and learning. In this review, the basic biology of the excitatory amino acids glutamate, glutamate receptors, GABA, and glycine will first be explored. In the second part of this review, the known pathophysiology and pathology will be described. (J Toxicol Pathol 2008; 21: 25-51)

show abstract

l-Glutamate-induced responses in OFF-type bipolar cells of the cat retina

Cited by 55 publications

References 23 publications

Differential expression of ionotropic glutamate receptor subunits in the outer retina

Differential expression of ionotropic glutamate receptor subunits in the outer retina

Kainate activation of horizontal, bipolar, amacrine, and ganglion cells in the rabbit retina

A Review of Glutamate Receptors I: Current Understanding of Their Biology

Contact Info

Product

Resources

About