L-Lysine as the Molecule Influencing Selective Brain Activity in Pain-Induced Behavior of Rats

Severyanova, L A; Лазаренко, В А; Плотников, Д. В.; Долгинцев, М. Е.; Kriukov, Alexey A.

doi:10.3390/ijms20081899

Cited by 16 publications

(10 citation statements)

References 21 publications

(25 reference statements)

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“…l -Lysine, by itself and in conjunction with l -arginine, has also been shown to protect against ischemic insults resulting from suppression of glutamate-induced neuronal activity [ 151 ]. Recently, l -lysine was shown to affect pain-induced behavior in rats [ 152 ].…”

Section: Amino Acidsmentioning

confidence: 99%

The Role of Amino Acids in Neurotransmission and Fluorescent Tools for Their Detection

Dalangin

Kim

Campbell

2020

IJMS

107

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Neurotransmission between neurons, which can occur over the span of a few milliseconds, relies on the controlled release of small molecule neurotransmitters, many of which are amino acids. Fluorescence imaging provides the necessary speed to follow these events and has emerged as a powerful technique for investigating neurotransmission. In this review, we highlight some of the roles of the 20 canonical amino acids, GABA and β-alanine in neurotransmission. We also discuss available fluorescence-based probes for amino acids that have been shown to be compatible for live cell imaging, namely those based on synthetic dyes, nanostructures (quantum dots and nanotubes), and genetically encoded components. We aim to provide tool developers with information that may guide future engineering efforts and tool users with information regarding existing indicators to facilitate studies of amino acid dynamics.

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Section: Amino Acidsmentioning

confidence: 99%

The Role of Amino Acids in Neurotransmission and Fluorescent Tools for Their Detection

Dalangin

Kim

Campbell

2020

IJMS

107

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“…As discussed before for L-3-methylhistidine, this discriminatory capability persisted throughout the TH process (see Fig 3 ). Lysine is an essential amino acid expressed particularly in neuronal proteins, and it is directly involved in modulating gene expression [ 33 ]. Experimental studies on murine models also suggest that this amino acid has a neuroprotective [ 34 ] and anti-inflammatory role.…”

Section: Discussionmentioning

confidence: 99%

Urinary metabotypes of newborns with perinatal asphyxia undergoing therapeutic hypothermia

et al. 2022

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Perinatal asphyxia (PA) still occurs in about three to five per 1,000 deliveries in developed countries; 20% of these infants show hypoxic-ischemic encephalopathy (HIE) on brain magnetic resonance imaging (MRI). The aim of our study was to apply metabolomic analysis to newborns undergoing therapeutic hypothermia (TH) after PA to identify a distinct metabotype associated with the development of HIE on brain MRI. We enrolled 53 infants born at >35 weeks of gestation with PA: 21 of them showed HIE on brain MRI (the “HIE” group), and 32 did not (the “no HIE” group). Urine samples were collected at 24, 48 and 72 hours of TH. Metabolomic data were acquired using high-resolution mass spectrometry and analyzed with univariate and multivariate methods. Considering the first urines collected during TH, untargeted analysis found 111 relevant predictors capable of discriminating between the two groups. Of 35 metabolites showing independent discriminatory power, four have been well characterized: L-alanine, Creatine, L-3-methylhistidine, and L-lysine. The first three relate to cellular energy metabolism; their involvement suggests a multimodal derangement of cellular energy metabolism during PA/HIE. In addition, seven other metabolites with a lower annotation level (proline betaine, L-prolyl-L-phenylalanine, 2-methyl-dodecanedioic acid, S-(2-methylpropionyl)-dihydrolipoamide-E, 2,6 dimethylheptanoyl carnitine, Octanoylglucuronide, 19-hydroxyandrost-4-ene-3,17-dione) showed biological consistency with the clinical picture of PA. Moreover, 4 annotated metabolites (L-lysine, L-3-methylhistidine, 2-methyl-dodecanedioic acid, S-(2-methylpropionyl)-dihydrolipoamide-E) retained a significant difference between the “HIE” and “no HIE” groups during all the TH treatment. Our analysis identified a distinct urinary metabotype associated with pathological findings on MRI, and discovered 2 putative markers (L-lysine, L-3-methylhistidine) which may be useful for identifying neonates at risk of developing HIE after PA.

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“…Animal studies suggest an increase in pain threshold when using lysine. 89 By participating in collagen synthesis and antibody production, it promotes accelerated tissue repair and infection control. Studies have shown a positive action of this amino acid in reducing the healing time of lesions caused by herpesviruses (HHV-1 and HHV-6\7), the number of lesions (HHV-6/7) and the severity of lesions (HHV-1 and HHV-6 \7).…”

Section: Role In Physiology and Ability Of The Virus To Establish Inf...mentioning

confidence: 99%

L‐lysine: Its antagonism with L‐arginine in controlling viral infection. Narrative literature review

Pedrazini

Silva²,

Groppo

2022

Brit J Clinical Pharma

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Knowledge about viral characteristics, mechanisms of entry into the host cell and multiplication/dissemination can help in the control and treatment of viral pathologies. Several nutritional factors linked to the host may favour viral multiplication and their control, may lead to new prophylactic alternatives and/or antiviral therapies.The objective of this review is to discuss the relationship between the amino acid Llysine and the control of viral infections, aiming at a possible therapeutic property.This research used databases such as PubMed, Web of Science, Scielo, Medline and Google Scholar, as well as searching for references cited by journals. The time frame covered the period between 1964 and January 2022. The observed studies have shown that the usual antiviral therapies are not able to interfere with the viruses in their latent state; however, they can interfere with the adhesion and fusion of viral particles or the production of proteins, which play an important role in viral epidemiology and control, particularly in the initial moment and in reactivation. Lysine is an amino acid that can interfere mainly in the formation of capsid proteins and DNA by a competitive antagonism with amino acid arginine, which is an essential amino acid for some viruses, and also by promoting the increase of arginase, increasing the catabolism of arginine. Although there is evidence of the importance of L-lysine in viral control, more studies are needed, with a view to new antiviral therapies.

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L-Lysine as the Molecule Influencing Selective Brain Activity in Pain-Induced Behavior of Rats

Cited by 16 publications

References 21 publications

The Role of Amino Acids in Neurotransmission and Fluorescent Tools for Their Detection

The Role of Amino Acids in Neurotransmission and Fluorescent Tools for Their Detection

Urinary metabotypes of newborns with perinatal asphyxia undergoing therapeutic hypothermia

L‐lysine: Its antagonism with L‐arginine in controlling viral infection. Narrative literature review

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