L-Lysine-Coated Magnetic Core–Shell Nanoparticles for the Removal of Acetylsalicylic Acid from Aqueous Solutions

Maciel, Ayessa P.; Gomide, Guilherme; Silva, Franciscarlos G da; Guerra, Ana Alice Andrade Meireles; Depeyrot, J.; Mezzi, A.; Campos, Alex Fabiano Cortez

doi:10.3390/nano13030514

Cited by 6 publications

(3 citation statements)

References 41 publications

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“…The FTIR of the functionalized biocomposites confirms the successful coating of amino acids on the MOF surface. Two short bands at 476 and 536 cm −1 correspond to C-H bending vibrations of Lys in pDNA@ZIF Lys , 1038 cm −1 for C-O stretching, and 1533 cm −1 for symmetric bending of the NH 3 + group [ 55 ]. In pDNA@ZIF His , the peaks for sp 2 C-H bending vibrations (at 479 and 538 cm −1 ), C-O stretching (at 1042 and 1238 cm −1 ), imidazole group C-N stretching (at 1118 cm −1 ), and COO - symmetric stretching (at 1348 cm −1 ) confirm the presence of the His molecule on the pDNA@ZIF surface [ 56 , 57 , 58 ].…”

Section: Resultsmentioning

confidence: 99%

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Amino Acid-Coated Zeolitic Imidazolate Framework for Delivery of Genetic Material in Prostate Cancer Cell

Polash,

Garlick-Trease,

Pyreddy

et al. 2023

Molecules

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Metal–organic frameworks (MOFs) are currently under progressive development as a tool for non-viral biomolecule delivery. Biomolecules such as proteins, lipids, carbohydrates, and nucleic acids can be encapsulated in MOFs for therapeutic purposes. The favorable physicochemical properties of MOFs make them an attractive choice for delivering a wide range of biomolecules including nucleic acids. Herein, a green fluorescence protein (GFP)-expressing plasmid DNA (pDNA) is used as a representative of a biomolecule to encapsulate within a Zn-based metal–organic framework (MOF) called a zeolitic imidazolate framework (ZIF). The synthesized biocomposites are coated with positively charged amino acids (AA) to understand the effect of surface functionalization on the delivery of pDNA to prostate cancer (PC-3) cells. FTIR and zeta potential confirm the successful preparation of positively charged amino acid-functionalized derivatives of pDNA@ZIF (i.e., pDNA@ZIFAA). Moreover, XRD and SEM data show that the functionalized derivates retain the pristine crystallinity and morphology of pDNA@ZIF. The coated biocomposites provide enhanced uptake of genetic material by PC-3 human prostate cancer cells. The AA-modulated fine-tuning of the surface charge of biocomposites results in better interaction with the cell membrane and enhances cellular uptake. These results suggest that pDNA@ZIFAA can be a promising alternative tool for non-viral gene delivery.

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Section: Resultsmentioning

confidence: 99%

“…Molecules 2023, 28, x FOR PEER REVIEW 4 of 14 1038 cm −1 for C-O stretching, and 1533 cm −1 for symmetric bending of the NH3 + group [55].…”

Section: Synthesis and Characterization Of Amino Acid-coated Pdna@zifmentioning

confidence: 99%

Amino Acid-Coated Zeolitic Imidazolate Framework for Delivery of Genetic Material in Prostate Cancer Cell

Polash,

Garlick-Trease,

Pyreddy

et al. 2023

Molecules

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“…The IEP of the OL-MNPs ( Figure 1 F, blue line) was approximately 4. The shift of IEP to lower pH values indicates the coating of nanoparticles with sodium oleate [ 30 , 33 ]. The subsequent modification of the OL-MNPs with poly-L-lysine is accompanied by a gradual shift of the IEP to the alkaline medium ( Figure 1 F, violet line) in the direction of the IEP of pure PLL, whose value in the literature is in the range from 9.47 to 10.6 [ 31 , 34 , 35 ].…”

Section: Resultsmentioning

confidence: 99%

Development of Positively Charged Poly-L-Lysine Magnetic Nanoparticles as Potential MRI Contrast Agent

et al. 2023

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A colloidal solution of magnetic nanoparticles (MNPs) modified with biocompatible positively charged poly-L-lysine (PLL) with an oleate (OL) layer employed as an initial coating was produced as a potential MRI contrast agent. The effect of various PLL/MNPs’ mass ratios on the samples’ hydrodynamic diameter, zeta potential, and isoelectric point (IEP) was studied by the dynamic light-scattering method. The optimal mass ratio for MNPs’ surface coating was 0.5 (sample PLL0.5-OL-MNPs). The average hydrodynamic particle size in the sample of PLL0.5-OL-MNPs was 124.4 ± 1.4 nm, and in the PLL-unmodified nanoparticles, it was 60.9 ± 0.2 nm, indicating that the OL-MNPs’ surface became covered by PLL. Next, the typical characteristics of the superparamagnetic behavior were observed in all samples. In addition, the decrease in saturation magnetizations from 66.9 Am2/kg for MNPs to 35.9 and 31.6 Am2/kg for sample OL-MNPs and PLL0.5-OL-MNPs also confirmed successful PLL adsorption. Moreover, we show that both OL-MNPs and PLL0.5-OL-MNPs exhibit excellent MRI relaxivity properties and a very high r2(*)/r1 ratio, which is very desirable in biomedical applications with required MRI contrast enhancement. The PLL coating itself appears to be the crucial factor in enhancing the relaxivity of MNPs in MRI relaxometry.

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Enhancing the efficiency of magnetically driven carbon nitride–based nanocomposites with magnetic nanoflowers for the removal of methylene blue dye at neutral pH

Rodovalho,

Rosa,

da Silva

et al. 2024

Environ Sci Pollut Res

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The present survey focuses on the elaboration of magnetic nanocomposites by the in-situ incorporation of magnetite (Fe 3 O 4 ) nanoparticles (NPs) with spherical and nano ower-like) morphologies in graphitic carbon nitride (g-C 3 N 4 ) sheets using two different synthetic routes. Nanomaterials are characterized by TEM, SEM, XRD, FTIR, BET, zetametry, vibrating sample magnetometry, and UV-vis absorption spectroscopy. The decoration of the carbon nitride matrix with the magnetic NPs enhanced optical and textural properties. The in uence of the shape of the magnetic NPs on the adsorptive and photocatalytic properties of the nanocomposites under different pH conditions was assessed from batch tests to remove methylene blue (MB) from aqueous solutions. In extreme pH conditions, the nanocomposites exhibited lower or equivalent MB removal capacity compared to the pure g-C 3 N 4 . However, at neutral medium, the nanocomposite with incorporated Fe 3 O 4 nano owers showed a signi cantly higher removal e ciency due to the combination of a high adsorption capacity and a good photocatalytic activity in this pH region. The proposed nanocomposite is a promising alternative to remove cationic dyes from water by magnetic assistance, since no pH adjustment of the polluted e uent is required, reducing costs and environmental impact in the dyeing industry.

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L-Lysine-Coated Magnetic Core–Shell Nanoparticles for the Removal of Acetylsalicylic Acid from Aqueous Solutions

Cited by 6 publications

References 41 publications

Amino Acid-Coated Zeolitic Imidazolate Framework for Delivery of Genetic Material in Prostate Cancer Cell

Amino Acid-Coated Zeolitic Imidazolate Framework for Delivery of Genetic Material in Prostate Cancer Cell

Development of Positively Charged Poly-L-Lysine Magnetic Nanoparticles as Potential MRI Contrast Agent

Enhancing the efficiency of magnetically driven carbon nitride–based nanocomposites with magnetic nanoflowers for the removal of methylene blue dye at neutral pH

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