2019
DOI: 10.1016/j.redox.2019.101238
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L-NAME releases nitric oxide and potentiates subsequent nitroglycerin-mediated vasodilation

Abstract: L-N G -Nitro arginine methyl ester (L-NAME) has been widely applied for several decades in both basic and clinical research as an antagonist of nitric oxide synthase (NOS). Herein, we show that L-NAME slowly releases NO from its guanidino nitro group. Daily pretreatment of rats with L-NAME potentiated mesenteric vasodilation induced by nitrodilators such as nitroglycerin, but not by NO. Release of NO also occurred with the NOS-inactive enantiomer D-NAME, but not with L-arginine or anothe… Show more

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Cited by 60 publications
(56 citation statements)
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“…However, l-NAME is not a specific NOS inhibitor; rather, it weakly inhibits all types of NOS and can even release NO. [79][80][81] Therefore, the above statement needs to be strengthened by further studies using a selective eNOS inhibitor. It is worth noting that different opinions exist regarding the role of eNOS in pulp flow.…”
Section: Anmentioning
confidence: 99%
“…However, l-NAME is not a specific NOS inhibitor; rather, it weakly inhibits all types of NOS and can even release NO. [79][80][81] Therefore, the above statement needs to be strengthened by further studies using a selective eNOS inhibitor. It is worth noting that different opinions exist regarding the role of eNOS in pulp flow.…”
Section: Anmentioning
confidence: 99%
“…In particular, DNIC#3 at pH 7 generated∼ 16 nM of NO, and DNIC#4 released 8 nM of NO after 50 s. Thus, these values are consistent with previously published data on the release of NO (Sanina et al, 2014a). Some threshold concentration of the cytotoxicity effect of NO has been demonstrated previously (Liu et al, 2019). The threshold doses for NO • induced cytotoxicity were shown to be 150 µM min in TK6 cells and 300 µM min in NH32 cells, respectively.…”
Section: Discussionmentioning
confidence: 66%
“…The main source of ROS in cells is oxidative phosphorylation. Mitochondrial dysfunction and oxidative stress are involved in the pathogenesis of many diseases (Grancara et al, 2015; Liu et al, 2019). Oxidative stress causes many degenerative diseases and cell death.…”
Section: Discussionmentioning
confidence: 99%
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