l-Thyroxine induces thermotolerance in yeast

Abstract

The cellular stress response (CSR) is a universal inducible reaction modulated, among others, by heat, drugs, and hormones. We aimed to investigate the role of L-thyroxine (T4) on the heat shock (HS) response in Saccharomyces cerevisiae. The CSR was evaluated by determining growth and viability of post-logarithmic phase grown yeast cultures after HS at 53°C for 30 min. We found that long-term T4 exposure can induce a dose-dependent and Hsp90 and H + trafficking-related thermotolerance in yeast.

Identification of a Thyroid Hormone Binding Site in Hsp90 with Implications for Its Interaction with Thyroid Hormone Receptor Beta

“…T4 enhanced thermotolerance in yeast. Nonionizing radiation, such as WiFi connection, may modify the morphology and expression of genes that encode heat shock proteins (Hsp) in the thyroid gland, or the two different thyroid hormone receptor (TR) types can act as oncogenes or as tumor suppressor genes in human cancer. − Furthermore, the thyroid hormone protects cardiomyocytes from H 2 O 2 -induced oxidative stress via the phosphoinositide 3-kinase (PI3K)-protein kinase B (Akt) signaling pathway, whereas hypothyroidism and hyperthyroidism have different effects on heart function. , …”

Triiodothyronine Acts as a Smart Influencer on Hsp90 via a Triiodothyronine Binding Site

“…Therefore, we investigated whether triiodothyronine could affect other proteins. Interestingly, it was shown that L-Thyroxine (T4) can enhance thermotolerance in yeast [11]. Hsp90 was selected as a cellular stress marker that forms a broad interactome of the cellular proteome.…”