La homocisteína: ¿El factor de riesgo cardiovascular del próximo milenio?

García, I. Suárez; Cerezo, J.F. Gómez; Blanco, Juan José Ríos; Hernández, Fernando; Rodríguez, J J Vázquez

doi:10.4321/s0212-71992001000400010

Cited by 10 publications

(7 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The report that statins can reduce the incidence of DVT, although not in the idiopathic type (2)(3)(4), can be considered a helpful criterion for correlating the two pathologies, but it is not sufficient for the demonstration of a causal correlation of the two vascular events. In the substance, the subjects with DVT and the controls have the same incidence of IMT and of plaques.…”

Section: Resultsmentioning

confidence: 95%

“…Another research work evaluated the association between current use of statins and risk of idiopathic venous thromboembolism and found that the use of this drug did not reduce the risk (3). Moreover, in recent years hyperhomocysteinemia has been considered an important risk factor for atherosclerosis and it has also been correlated with an increased risk for DVT (4,5).…”

mentioning

confidence: 96%

See 1 more Smart Citation

Atherosclerosis and Secondary Deep Vein Thrombosis: A Difficult Correlation

Bilora¹,

Boccioletti²,

Petrobelli³

et al. 2003

Clin Appl Thromb Hemost

View full text Add to dashboard Cite

The aim of this study was to verify the degree of atherosclerosis in a group of subjects affected by secondary deep vein thrombosis and in a matched control group. Sixty-three patients were studied. Of these, 19 were cases (mean age 62.2 +/- 1.2) and 16 were controls (mean age 59.3 +/- 2.7). Twenty-eight were excluded because they were affected by hyperhomocysteinemia. The arterial tree was examined by means of echo color Doppler, and the intima media thickness and the presence of and degree of plaques bilaterally in the carotid and femoral artery and abdominal aorta were measured with a computerized method. No difference was found in the 2 groups as concerns intima media thickness or plaques in the arterial district explored. Secondary deep vein thrombosis is not a greater risk factor for atherosclerosis.

show abstract

Section: Resultsmentioning

confidence: 95%

mentioning

confidence: 96%

Atherosclerosis and Secondary Deep Vein Thrombosis: A Difficult Correlation

Bilora¹,

Boccioletti²,

Petrobelli³

et al. 2003

Clin Appl Thromb Hemost

View full text Add to dashboard Cite

show abstract

“…Mutations in the MTHFR gene disrupt folate acid metabolism, resulting in methyltetrahydrofolate deficiency and HHcy with hypomethioninemia. Disorders related to cobalamin (cbl-) metabolism, particularly cblC, combine methylmalonic acidemia (MMA) with HCU [ 4 , 18 ]. These disorders manifest with significantly elevated Hcy levels (>50 μmol/L).…”

Section: Types Of Hyperhomocysteinemias (Hhcy)mentioning

confidence: 99%

Hyperhomocysteinemia in Adult Patients: A Treatable Metabolic Condition

González-Lamuño,

Arrieta-Blanco,

Fuentes

et al. 2023

Nutrients

View full text Add to dashboard Cite

Hyperhomocysteinemia (HHcy) is recognized as an independent risk factor for various significant medical conditions, yet controversy persists around its assessment and management. The diagnosis of disorders afffecting homocysteine (Hcy) metabolism faces delays due to insufficient awareness of its clinical presentation and unique biochemical characteristics. In cases of arterial or venous thrombotic vascular events, particularly with other comorbidities, it is crucial to consider moderate to severe HHcy. A nutritional approach to HHcy management involves implementing dietary strategies and targeted supplementation, emphasizing key nutrients like vitamin B6, B12, and folate that are crucial for Hcy conversion. Adequate intake of these vitamins, along with betaine supplementation, supports Hcy remethylation. Lifestyle modifications, such as smoking cessation and regular physical activity, complement the nutritional approach to enhance Hcy metabolism. For individuals with HHcy, maintaining a plasma Hcy concentration below 50 μmol/L consistently is vital to lowering the risk of vascular events. Collaboration with healthcare professionals and dietitians is essential for developing personalized dietary plans addressing the specific needs and underlying health conditions. This integrated approach aims to optimize metabolic processes and reduce the associated health risks.

show abstract

“…Mediante el metabolismo de la Met se pueden generar metabolitos intermedios como la homocisteina y también productos como la cisteína (Cys) (Li, Yin, Li, Kim, & Wu, 2007). La síntesis de Cys mediante la Met es producto de la transulfuración, donde se genera una unión de serina a la Met (Suárez, Gómez, Ríos, Barbado, & Vázquez, 2001). Una de las funciones de la Cys es la síntesis del glutatión (GSH) (Li et al, 2007), siendo un tiol formado por tres pétidos (γ-L-glutamil-L-cisteína-glicina) (Díaz-Hung, González, & Blanco, 2015).…”

Section: Metionina Y Su Función Antioxidanteunclassified

Activación del sistema inmune en cerdos y su requerimiento de metionina, treonina y triptófano

Martínez-Aguilar

Salazar-Villanea

2020

Nut. Anim. Trop.

View full text Add to dashboard Cite

Las altas densidades de animales en granjas porcinas son un desafío para el adecuado estado de salud de los animales, favoreciendo la presencia de diversas enfermedades. Estas enfermedades provocan que el organismo del animal realice ajustes costosos desde el punto de vista metabólico, incrementando el gasto energético y provocando una desviación de los nutrientes utilizados para cubrir los requerimientos de mantenimiento, crecimiento y reparación tejidos, hacia el funcionamiento del sistema inmune. Por lo tanto, el objetivo de esta revisión literaria es analizar los efectos de la activación del sistema inmune en cerdos desafiados sanitariamente sobre el requerimiento de algunos aminoácidos, con el fin de valorar el componente inmune como una parte clave para una nutrición más efectiva. Ante la activación del sistema inmune se producen citoquinas proinflamatorias, las cuales a su vez estimulan la síntesis de proteínas de fase aguda. Esta síntesis incrementa el requerimiento de ciertos aminoácidos, de tal forma que si la necesidad de aminoácidos sobrepasa la disponibilidad a nivel sérico, se presentará una inducción al catabolismo de proteína muscular; además, estos aminoácidos también son utilizados como fuente de energía y precursores antioxidantes. La metionina, treonina y triptófano son los principales aminoácidos que influyen en la respuesta del sistema inmune a enfermedades clínicas y subclínicas. En conclusión, una dieta que supla, ante un reto inmunológico, únicamente los requerimientos de mantenimiento y crecimiento de los cerdos, sin considerar los requerimientos del sistema inmune, puede producir una deficiencia nutricional y menor rendimiento productivo del animal. Por lo tanto, se debe valorar la necesidad de suplementar estos aminoácidos por encima de la cantidad recomendada en un perfil de proteína ideal, especialmente bajo condiciones de estrés sanitario.

show abstract

La homocisteína: ¿El factor de riesgo cardiovascular del próximo milenio?

Cited by 10 publications

References 82 publications

Atherosclerosis and Secondary Deep Vein Thrombosis: A Difficult Correlation

Atherosclerosis and Secondary Deep Vein Thrombosis: A Difficult Correlation

Hyperhomocysteinemia in Adult Patients: A Treatable Metabolic Condition

Activación del sistema inmune en cerdos y su requerimiento de metionina, treonina y triptófano

Contact Info

Product

Resources

About