La política focalizada en el programa de vacunación contra el Virus del Papiloma Humano en México: aspectos éticos

Torres-Poveda, Kirvis; Cuadra-Hernández, Silvia Magali; Castro-Romero, Julieta Ivone; Madrid‐Marina, Vicente

doi:10.4067/s1726-569x2011000100010

Cited by 16 publications

(8 citation statements)

References 17 publications

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“…The bivalent vaccine (Cervarix) was implemented with a three-dose schedule (0, 6, and 60 months) [57]. At present, a scenario of universal vaccination coverage against HPV in Mexico is not viable, given the high costs of the vaccine [58]. The most feasible cost-effective option was to follow a selective vaccination strategy, where women living in marginalized areas and with less access to health services have priority to receive the vaccine [58].…”

Section: Discussionmentioning

confidence: 99%

“…At present, a scenario of universal vaccination coverage against HPV in Mexico is not viable, given the high costs of the vaccine [58]. The most feasible cost-effective option was to follow a selective vaccination strategy, where women living in marginalized areas and with less access to health services have priority to receive the vaccine [58]. Currently, the coverage of the HPV vaccine in Mexico is 40% [59].…”

Section: Discussionmentioning

confidence: 99%

“…This kit is based on simultaneous real-time amplification (multiplex PCR) of DNA fragments of 14 HR-HPV types (HPV 16,18,31,33,35,39,45,51,52,56,58,59, 66, and 68) and a DNA fragment of the ß-globin gene as an internal endogenous control, carried out in four separated reaction tubes. Each genotype is detected in a separate fluorescent channel (FAM, JOE, ROX, and Cy5) that allows its detection and quantification (a total of 16 qPCR probes are measured).…”

Section: Hpv Genotyping and Viral Loadmentioning

confidence: 99%

“…The most common HR-HPV types in CC (16,18,31,33,35,39,45,51,52,56,58,59 and 68) are associated with low-grade cervical lesions (LSIL), high-grade cervical lesions (HSIL), and CC [10]. HPV types 16 and 18 are responsible for 70% of HPV associated cancer cases worldwide [11].…”

Section: Introductionmentioning

confidence: 99%

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Multiple HPV Infections and Viral Load Association in Persistent Cervical Lesions in Mexican Women

Oyervides-Muñoz

Pérez-Maya

Sánchez‐Domínguez

et al. 2020

Viruses

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Persistent high-risk human papillomavirus (HR-HPV) infections play a major role in the development of invasive cervical cancer (CC), and screening for such infections is in many countries the primary method of detecting and preventing CC. HPV typing can be used for triage and risk stratification of women with atypical squamous cells of undetermined significance (ASC-US)/low-grade cervical lesions (LSIL), though the current clinical practice in Mexico is to diagnose CC or its preceding conditions mainly via histology and HR-HPV detection. Additional information regarding these HPV infections, such as viral load and co-infecting agents, might also be useful for diagnosing, predicting, and evaluating the possible consequences of the infection and of its prevention by vaccination. The goal of this follow-up hospital case study was to determine if HPV types, multiple HPV infections, and viral loads were associated with infection persistence and the cervical lesion grade. A total of 294 cervical cytology samples drawn from patients with gynecological alterations were used in this study. HPV types were identified by real-time PCR DNA analysis. A subset of HPV-positive patients was reevaluated to identify persistent infections. We identified HPV types 16, 18, and 39 as the most prevalent. One hundred five of the patients (59%) were infected with more than one type of HPV. The types of HPV associated with multiple HPV infections were 16, 18, and 39. In the follow-up samples, 38% of patients had not cleared the initially detected HPV infection, and these were considered persistent. We found here an association between multiple HPV infections and high viral loads with and infection persistence. Our findings suggest there are benefits in ascertaining viral load and multiple HPV infections status of HR-HPV infections for predicting the risk of persistence, a requirement for developing CC. These findings contribute to our understanding of HPV epidemiology and may allow screening programs to better assess the cancer-developing risks associated with individual HR-HPV infections.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Hpv Genotyping and Viral Loadmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Multiple HPV Infections and Viral Load Association in Persistent Cervical Lesions in Mexican Women

Oyervides-Muñoz

Pérez-Maya

Sánchez‐Domínguez

et al. 2020

Viruses

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“…y urbanas, con dificultades en el acceso a servicios de salud y a la CCV(56). No obstante, garantizar la vacunación sin mejorar el acceso a la CCV periódica y sin intervenir los determinantes sociales de la salud, sigue siendo una tarea incompleta.En este punto, es fundamental apoyar la investigación independiente sobre el desarrollo de las vacunas contra el VPH y promover, desde las agencias regulatorias locales, la difusión de guías éticas y consensos sobre la confección de los documentos de CI(57), así como la generación de escenarios pedagógicos, tanto para los profesionales de la salud, como para la población general, conforme avanza la investigación sobre las vacunas contra el VPH.…”

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La vacuna contra el Virus del Papiloma Humano: estado de la cuestión, principio de proporcionalidad y consentimiento informado

Bustamante

2016

Acta bioeth.

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Resumen: Entre los debates actuales en torno a las prácticas de vacunación, la vacuna contra el Virus de Papiloma Humano (VPH) formula diversos desafíos desde la bioética: por una parte, existen controversias en cuanto al perfil de eficacia y seguridad de las vacunas comercializadas, así como respecto de su costo-efectividad. Es evidente en estudios empíricos que el proceso de consentimiento informado no ofrece los elementos necesarios para que las pacientes y sus representantes legales puedan participar de forma significativa en el proceso de toma de decisiones en torno a la vacunación. El presente artículo presenta una revisión sobre el estado de la cuestión, ofrece un análisis desde la bioética a partir del principio de proporcionalidad y el método deliberativo-sincrético y sugiere algunos aportes para optimizar el proceso de consentimiento informado para la vacuna contra el VPH. Palabras clave: vacunación, programas de inmunización, vacunas contra papillomavirus, bioética, consentimiento informado The vaccine against Human Papilloma Virus: state of the question, proportionality principle and informed consent Abstract: Within the current discussions on immunization practices, Human Papillomavirus (HPV) made various challenges from bioethics: firstly, there are controversies regarding the efficacy and safety profile of marketed vaccines, and with respect to their cost-effectiveness. Around the discussion is evident in empirical studies that the informed consent process does not provide the necessary elements for the patients and their legal representatives can participate meaningfully in the process of making decisions about vaccination. This article presents an overview of the status of the issue, with an analysis from bioethics from the principle of proportionality and the deliberative syncretic method and suggests some input to optimize the process of informed consent for the HPV vaccine.

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Factors Influencing Mexican Women's Decisions to Vaccinate Daughters Against HPV in the United States and Mexico

Wentzell

Flores

Salmerón

et al. 2016

Family &Amp; Community Health

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Mexican and Mexican-American women bear high cervical cancer burdens, yet relationships between mothers' experiences of vaccinating daughters against cervical cancer-causing human papillomavirus (HPV) on both sides of the border are unknown. We surveyed 400 Mexican-born women in Oxnard, California, United States and Cuernavaca, Morelos, Mexico, about their beliefs and practices regarding daughters' HPV vaccination, conducting in-depth interviews with 35 participants. Contextualizing interview findings in survey data, we identify key factors influencing mothers' experiences regarding daughters' HPV vaccination in both countries. Although US acculturation influenced some participants' concerns, US and Mexico participants overwhelmingly desired eventual vaccination; structural rather than cultural barriers limited vaccine uptake.

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La política focalizada en el programa de vacunación contra el Virus del Papiloma Humano en México: aspectos éticos

Cited by 16 publications

References 17 publications

Multiple HPV Infections and Viral Load Association in Persistent Cervical Lesions in Mexican Women

Multiple HPV Infections and Viral Load Association in Persistent Cervical Lesions in Mexican Women

La vacuna contra el Virus del Papiloma Humano: estado de la cuestión, principio de proporcionalidad y consentimiento informado

Factors Influencing Mexican Women's Decisions to Vaccinate Daughters Against HPV in the United States and Mexico

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