La proteína C reactiva como blanco terapéutico en la prevención cardiovascular: ¿ficción o realidad?

Heres-Álvarez, Flor de la C.; Peix-González, Amalia

doi:10.1016/s1131-3587(11)15006-2

Cited by 1 publication

(2 citation statements)

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“…Numerous studies have demonstrated the active participation of this molecule in the atherogenic process [6], and due to the discovery of high-sensitivity techniques for its determination, its stable plasmatic concentrations, and its relatively low costs, it may be of great use in the identification of patients at high risk, as a prognostic indicator and even as a therapeutic target in large populations [7]. …”

Section: Introductionmentioning

confidence: 99%

“…The biomolecule with the greater body of research both from a molecular and epidemiological perspective is C-reactive protein (CRP), a plasma protein of the pentraxin family and an acute phase reactant, which displays high sensitivity as a general inflammation marker [ 5 ]. Numerous studies have demonstrated the active participation of this molecule in the atherogenic process [ 6 ], and due to the discovery of high-sensitivity techniques for its determination, its stable plasmatic concentrations, and its relatively low costs, it may be of great use in the identification of patients at high risk, as a prognostic indicator and even as a therapeutic target in large populations [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

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C-Reactive Protein: Clinical and Epidemiological Perspectives

Salazar

Martínez

Chávez-Castillo

et al. 2014

Cardiology Research and Practice

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An important etiopathogenic component of cardiovascular disease is atherosclerosis, with inflammation being an essential event in the pathophysiology of all clinical pictures it comprises. In recent years, several molecules implicated in this process have been studied in order to assess cardiovascular risk in both primary and secondary prevention. C-reactive protein is a plasmatic protein of the pentraxin family and an acute phase reactant, very useful as a general inflammation marker. Currently, it is one of the most profoundly researched molecules in the cardiovascular field, yet its clinical applicability regarding cardiovascular risk remains an object of discussion, considered by some as a simple marker and by others as a true risk factor. In this sense, numerous studies propose its utilization as a predictor of cardiovascular risk through the use of high-sensitivity quantification methods for the detection of values <1 mg/L, following strict international guidelines. Increasing interest in these clinical findings has led to the creation of modified score systems including C-reactive protein concentrations, in order to enhance risk scores commonly used in clinical practice and offer improved care to patients with cardiovascular disease, which remains the first cause of mortality at the worldwide, national, and regional scenarios.

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Section: Introductionmentioning

confidence: 99%