Lab-on-a-Chip: A Revolution in Biological and Medical Sciences.

Figeys, Daniel; Pinto, Devanand M.

doi:10.1021/ac002800y

Cited by 538 publications

(352 citation statements)

References 23 publications

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“…The emphasis is on polymers that can take very low viscosities under certain conditions, so as to allow easy loading in the channel. 16) Lab-on-a-chip: a revolution in biological and medical sciences [200]. This is a short and accessible review on some of the challenges and promises of these new technologies.…”

Section: Discussion: An Annotated List Of Useful Articlesmentioning

confidence: 99%

Theory of DNA electrophoresis (∼ 1999 –2002 ½)

et al. 2002

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Over the last two decades, the introduction of new methods such as pulsed-field gel electrophoresis and capillary array electrophoresis has made it possible to map and sequence entire genomes, including our own. The development of these experimental methods has been helped by the progress of theoretical and computational sciences, and the interactions between these three modi operandi of modern science are still pushing the limits of our technologies. We now see a clear trend towards proteomics and microfluidic (even nanofluidic!) devices. In this review, we take a look at the progress of the field over the last 3 years using the glasses of the theoretical scientist and focusing mostly on new ideas and concepts. About a dozen different subfields are discussed and reviewed. We conclude by giving a commented list of some of the best review articles published over the last 2-3 years.

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Section: Discussion: An Annotated List Of Useful Articlesmentioning

confidence: 99%

Theory of DNA electrophoresis (∼ 1999 –2002 ½)

et al. 2002

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“…Microfabricated microfluidic analytical devices, integrating multiple sample-handling processes with the actual measurement step on a microchip platform (Figure 4), are of considerable recent interest. 28,29 For obvious reasons, such devices are referred to as "lab-on-FIGURE 2. Electrochemical biosensors: intimate coupling of specific biorecognition events and an electrical signal transduction.…”

Section: Real-time Electrochemical Monitoringmentioning

confidence: 99%

Real-Time Electrochemical Monitoring: Toward Green Analytical Chemistry

2002

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This Account presents a survey of recent advances in electrochemical sensing technology relevant to green analytical chemistry and examines the potential advantages, limitations, and applications of these monitoring devices. Stricter environmental control and effective process monitoring have created considerable demands for innovative analytical methodologies. New devices and protocols, with negligible waste generation or no hazardous substances, and in situ real-time monitoring capability are particularly needed for addressing the challenges of green analytical chemistry. The coupling of modern electrochemical detection principles with recent advances in molecular recognition, microelectronics, and microfabrication has led to powerful, compact, and "user-friendly" analytical devices. The unique features of such electrochemical monitoring systems make them particularly attractive for addressing environmental and industrial problems and the challenges of green chemistry. These developments allow the instrument to be taken to the sample (rather than the traditional way of bringing the sample to the laboratory) and hence to ensure effective process or pollution control.

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“…At the same time, the accurate control and manipulation of multilayer microscale flows has become increasingly popular in modern biomedical and other applications. Examples include techniques for concentrating leukocytes from whole blood samples (see SooHoo & Walker 2009), integrated lab-on-chip systems (see Beebe et al 2002;Figeys & Pinto 2000;Hibara et al 2001;Surmeian et al 2002), and the use of microfluidic devices in food engineering (Skurtys & Aguilera 2008). Potential applications in MEMS (micro-electro-mechanical) devices in the aerospace industry have been suggested, such as microthrusters that can propel small scale spacecrafts and satellites -see (Polsin & Choueiri 2002).…”

Section: Introductionmentioning

confidence: 99%

Nonlinear interfacial dynamics in stratified multilayer channel flows

2013

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The dynamics of viscous immiscible pressure-driven multilayer flows in channels are investigated using a combination of modelling, analysis and numerical computations. More specifically the particular system of three stratified layers with two internal fluid-fluid interfaces is considered in detail in order to identify the nonlinear mechanisms involved due to multiple fluid surface interactions. The approach adopted is analytical/asymptotic and is valid for interfacial waves that are long compared to the channel height or individual undisturbed liquid layer thicknesses. This leads to a coupled system of fully nonlinear partial differential equations of Benney-type that contain a small slenderness parameter that cannot be scaled out of the problem. This system is in turn used to develop a consistent coupled system of weakly nonlinear evolution equations, and it is shown that this is possible only if the underlying base-flow and fluid parameters satisfy certain conditions that enable a synchronous Galilean transformation to be performed at leading order. Two distinct canonical cases (all terms in the equations are of the same order) are identified in the absence and presence of inertia, respectively. The resulting systems incorporate all the active physical mechanisms at Reynolds numbers that are not large, namely, nonlinearities, inertia-induced instabilities (at non-zero Reynolds number) and surface tension stabilisation of sufficiently short waves. The coupled system supports several instabilities that are not found in single long-wave equations including, transitional instabilities due to a change of type of the flux nonlinearity from hyperbolic to elliptic, kinematic instabilities due to the presence of complex eigenvalues in the linearised advection matrix leading to a resonance between the interfaces, and the possibility of long-wave instabilities induced by an interaction between the flux function of the system and the surface tension terms. All these instabilities are followed into the nonlinear regime by carrying out extensive numerical simulations using spectral methods on periodic domains. It is established that instabilities leading to coherent structures in the form of nonlinear travelling waves are possible even at zero Reynolds number, in contrast to single interface (two-layer) systems; in addition, even in parameter regimes where the flow is linearly stable, the coupling of the flux functions and their hyperbolic-elliptic transitions lead to coherent structures for initial disturbances above a threshold value. When inertia is present an additional short-wave instability enters and the systems become general coupled Kuramoto-Sivashinsky type equations. Extensive numerical experiments indicate a rich landscape of dynamical behaviour including nonlinear travelling waves, time-periodic travelling states and chaotic dynamics. It is also established that it is possible to regularise the chaotic dynamics into travelling wave pulses by enhancing the inertialess instabilities through the advective terms. ...

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Lab-on-a-Chip: A Revolution in Biological and Medical Sciences.

Cited by 538 publications

References 23 publications

Theory of DNA electrophoresis (∼ 1999 –2002 ½)

Theory of DNA electrophoresis (∼ 1999 –2002 ½)

Real-Time Electrochemical Monitoring: Toward Green Analytical Chemistry

Nonlinear interfacial dynamics in stratified multilayer channel flows

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