Lab-on-a-Chip Devices for Point-of-Care Medical Diagnostics

Point-of-care diagnostics for infectious diseases: From methods to devices

“…LOC devices are highly integrated and automated manipulation microfluidic devices that can rapidly conduct sample inlet and preparation, reagent manipulation, detection as well as result analysis in a unique platform, which have significantly facilitated the transformation processes of POC devices towards miniaturization, portability, integration, and automation of multiple assay functions into a single instrument [319] , [320] , [321] , [322] , [323] . Compared with conventional detection methods, highly integrated LOC devices exhibited several considerable merits such as rapid detection, ease of multiplexing and integration, small reagent volume consumption, cost effectiveness, high accuracy, and high portability [321] , [322] , [324] , [325] .…”

Diagnosis of Herpes Simplex Virus: Laboratory and Point-of-Care Techniques

“…Microfluidic platforms have been widely used for POC devices due to their low cost, portability, and ability to support high yield assays. Microfluidic platforms typically utilize channels of dimension less than 1000 micron, which allow rapid diffusion of reagents and samples, laminar flow, and large surface-to-volume ratios and facilitate tests with small sample volumes [ 158 , 159 , 160 , 161 ]. Microchannels can be made of any suitable material, such as polymers, paper, glass, and fibers.…”

Lab on a Chip: Bioreactors miniaturization for rapid optimization of biomedical processes and its impact on SARS-CoV-2 diagnosis

“…As a result, scalability considerations must drive the materials, the design, and the fabrication methods used for such devices. Advances in 3D printing technology will likely start to bridge that gap shortly to build plastic-based MBRs 42 .…”

“…A new method of detection and analysis of samples is through the use of smartphones (SP), thanks to their sophisticated technological characteristics, such as high-quality cameras, great computational power, and easy connectivity; these have facilitated its integration as an analytical detection tool. SP-based tests measure optical variables such as bright field, colorimetry, luminescence, and fluorescence 42 . Lymph node on a chip: used in research simulating microstructures of the paracortical region of the lymph node to examine the dynamics of interaction between dendritic cells and T cells.…”